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Hydrophobic Optimization of Functional Poly(TPAE-co-suberoyl chloride) for Extrahepatic mRNA Delivery following Intravenous Administration †

Messenger RNA (mRNA) has generated great attention due to its broad potential therapeutic applications, including vaccines, protein replacement therapy, and immunotherapy. Compared to other nucleic acids (e.g., siRNA and pDNA), there are more opportunities to improve the delivery efficacy of mRNA th...

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Detalles Bibliográficos
Autores principales:	Yu, Xueliang, Liu, Shuai, Cheng, Qiang, Lee, Sang M., Wei, Tuo, Zhang, Di, Farbiak, Lukas, Johnson, Lindsay T., Wang, Xu, Siegwart, Daniel John
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624493/ https://www.ncbi.nlm.nih.gov/pubmed/34834329 http://dx.doi.org/10.3390/pharmaceutics13111914

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