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Early Gut Microbiota Colonisation of Premature Infants Fed with Breastmilk or Formula with or without Probiotics: A Cohort Study

Premature infants have a fragile ecology of the gut microbiota, which is associated with many health problems and may be influenced by formula versus breast feeding. The present study investigated differences in the process of gut microbiota colonisation in preterm infants fed with breastmilk or for...

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Autores principales: Chi, Cheng, Fan, Yali, Li, Cheng, Li, Yu, Guo, Shan, Li, Tianhe, Buys, Nicholas, Clifton, Vicki L., Colditz, Paul B., Yin, Chenghong, Sun, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624512/
https://www.ncbi.nlm.nih.gov/pubmed/34836323
http://dx.doi.org/10.3390/nu13114068
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author Chi, Cheng
Fan, Yali
Li, Cheng
Li, Yu
Guo, Shan
Li, Tianhe
Buys, Nicholas
Clifton, Vicki L.
Colditz, Paul B.
Yin, Chenghong
Sun, Jing
author_facet Chi, Cheng
Fan, Yali
Li, Cheng
Li, Yu
Guo, Shan
Li, Tianhe
Buys, Nicholas
Clifton, Vicki L.
Colditz, Paul B.
Yin, Chenghong
Sun, Jing
author_sort Chi, Cheng
collection PubMed
description Premature infants have a fragile ecology of the gut microbiota, which is associated with many health problems and may be influenced by formula versus breast feeding. The present study investigated differences in the process of gut microbiota colonisation in preterm infants fed with breastmilk or formula with or without probiotics before 12 weeks. This cohort study recruited 138 premature infants; 31 in the breastmilk (BM) group, 59 in the probiotics formula (PF) group and 48 in the non-probiotics formula (NPF) group, according to the feeding practice they received at birth. Gut bacterial composition was identified with 16S rRNA gene sequencing in faecal samples collected at 1 week, 6 weeks and 12 weeks after birth. The alpha diversity was higher in the PF group compared to the other groups at week 1 and 6 (both p < 0.01) but showed no difference at week 12. The beta diversity of the three groups showed a trend towards similarity at the first two stages (p < 0.001 and p = 0.009, respectively) and finally showed no difference at week 12. Canonical redundancy analysis showed that feeding type could explain the difference in gut microbiota composition at week one and six (both p < 0.01). At genus level, Bifidobacterium was enriched in the PF group, while the Enterococcus and Streptococcus was enriched in the NPF group. In summary, formula with probiotics feeding after birth can affect gut microbiota colonisation and lead to a bacterial community with less potential pathogens.
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spelling pubmed-86245122021-11-27 Early Gut Microbiota Colonisation of Premature Infants Fed with Breastmilk or Formula with or without Probiotics: A Cohort Study Chi, Cheng Fan, Yali Li, Cheng Li, Yu Guo, Shan Li, Tianhe Buys, Nicholas Clifton, Vicki L. Colditz, Paul B. Yin, Chenghong Sun, Jing Nutrients Article Premature infants have a fragile ecology of the gut microbiota, which is associated with many health problems and may be influenced by formula versus breast feeding. The present study investigated differences in the process of gut microbiota colonisation in preterm infants fed with breastmilk or formula with or without probiotics before 12 weeks. This cohort study recruited 138 premature infants; 31 in the breastmilk (BM) group, 59 in the probiotics formula (PF) group and 48 in the non-probiotics formula (NPF) group, according to the feeding practice they received at birth. Gut bacterial composition was identified with 16S rRNA gene sequencing in faecal samples collected at 1 week, 6 weeks and 12 weeks after birth. The alpha diversity was higher in the PF group compared to the other groups at week 1 and 6 (both p < 0.01) but showed no difference at week 12. The beta diversity of the three groups showed a trend towards similarity at the first two stages (p < 0.001 and p = 0.009, respectively) and finally showed no difference at week 12. Canonical redundancy analysis showed that feeding type could explain the difference in gut microbiota composition at week one and six (both p < 0.01). At genus level, Bifidobacterium was enriched in the PF group, while the Enterococcus and Streptococcus was enriched in the NPF group. In summary, formula with probiotics feeding after birth can affect gut microbiota colonisation and lead to a bacterial community with less potential pathogens. MDPI 2021-11-14 /pmc/articles/PMC8624512/ /pubmed/34836323 http://dx.doi.org/10.3390/nu13114068 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chi, Cheng
Fan, Yali
Li, Cheng
Li, Yu
Guo, Shan
Li, Tianhe
Buys, Nicholas
Clifton, Vicki L.
Colditz, Paul B.
Yin, Chenghong
Sun, Jing
Early Gut Microbiota Colonisation of Premature Infants Fed with Breastmilk or Formula with or without Probiotics: A Cohort Study
title Early Gut Microbiota Colonisation of Premature Infants Fed with Breastmilk or Formula with or without Probiotics: A Cohort Study
title_full Early Gut Microbiota Colonisation of Premature Infants Fed with Breastmilk or Formula with or without Probiotics: A Cohort Study
title_fullStr Early Gut Microbiota Colonisation of Premature Infants Fed with Breastmilk or Formula with or without Probiotics: A Cohort Study
title_full_unstemmed Early Gut Microbiota Colonisation of Premature Infants Fed with Breastmilk or Formula with or without Probiotics: A Cohort Study
title_short Early Gut Microbiota Colonisation of Premature Infants Fed with Breastmilk or Formula with or without Probiotics: A Cohort Study
title_sort early gut microbiota colonisation of premature infants fed with breastmilk or formula with or without probiotics: a cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624512/
https://www.ncbi.nlm.nih.gov/pubmed/34836323
http://dx.doi.org/10.3390/nu13114068
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