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Natural Products Induce Lysosomal Membrane Permeabilization as an Anticancer Strategy
Cancer is a global health and economic issue. The majority of anticancer therapies become ineffective due to frequent genomic turnover and chemoresistance. Furthermore, chemotherapy and radiation are non-specific, killing all rapidly dividing cells including healthy cells. In this review, we examine...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624533/ https://www.ncbi.nlm.nih.gov/pubmed/34822366 http://dx.doi.org/10.3390/medicines8110069 |
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author | Halaby, Reginald |
author_facet | Halaby, Reginald |
author_sort | Halaby, Reginald |
collection | PubMed |
description | Cancer is a global health and economic issue. The majority of anticancer therapies become ineffective due to frequent genomic turnover and chemoresistance. Furthermore, chemotherapy and radiation are non-specific, killing all rapidly dividing cells including healthy cells. In this review, we examine the ability of some natural products to induce lysosomal-mediated cell death in neoplastic cells as a way to kill them more specifically than conventional therapies. This list is by no means exhaustive. We postulate mechanisms to explain lysosomal membrane permeabilization and its role in triggering cell death in cancer cells. |
format | Online Article Text |
id | pubmed-8624533 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86245332021-11-27 Natural Products Induce Lysosomal Membrane Permeabilization as an Anticancer Strategy Halaby, Reginald Medicines (Basel) Review Cancer is a global health and economic issue. The majority of anticancer therapies become ineffective due to frequent genomic turnover and chemoresistance. Furthermore, chemotherapy and radiation are non-specific, killing all rapidly dividing cells including healthy cells. In this review, we examine the ability of some natural products to induce lysosomal-mediated cell death in neoplastic cells as a way to kill them more specifically than conventional therapies. This list is by no means exhaustive. We postulate mechanisms to explain lysosomal membrane permeabilization and its role in triggering cell death in cancer cells. MDPI 2021-11-10 /pmc/articles/PMC8624533/ /pubmed/34822366 http://dx.doi.org/10.3390/medicines8110069 Text en © 2021 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Halaby, Reginald Natural Products Induce Lysosomal Membrane Permeabilization as an Anticancer Strategy |
title | Natural Products Induce Lysosomal Membrane Permeabilization as an Anticancer Strategy |
title_full | Natural Products Induce Lysosomal Membrane Permeabilization as an Anticancer Strategy |
title_fullStr | Natural Products Induce Lysosomal Membrane Permeabilization as an Anticancer Strategy |
title_full_unstemmed | Natural Products Induce Lysosomal Membrane Permeabilization as an Anticancer Strategy |
title_short | Natural Products Induce Lysosomal Membrane Permeabilization as an Anticancer Strategy |
title_sort | natural products induce lysosomal membrane permeabilization as an anticancer strategy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624533/ https://www.ncbi.nlm.nih.gov/pubmed/34822366 http://dx.doi.org/10.3390/medicines8110069 |
work_keys_str_mv | AT halabyreginald naturalproductsinducelysosomalmembranepermeabilizationasananticancerstrategy |