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Natural Products Induce Lysosomal Membrane Permeabilization as an Anticancer Strategy

Cancer is a global health and economic issue. The majority of anticancer therapies become ineffective due to frequent genomic turnover and chemoresistance. Furthermore, chemotherapy and radiation are non-specific, killing all rapidly dividing cells including healthy cells. In this review, we examine...

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Detalles Bibliográficos
Autor principal: Halaby, Reginald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624533/
https://www.ncbi.nlm.nih.gov/pubmed/34822366
http://dx.doi.org/10.3390/medicines8110069
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author Halaby, Reginald
author_facet Halaby, Reginald
author_sort Halaby, Reginald
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description Cancer is a global health and economic issue. The majority of anticancer therapies become ineffective due to frequent genomic turnover and chemoresistance. Furthermore, chemotherapy and radiation are non-specific, killing all rapidly dividing cells including healthy cells. In this review, we examine the ability of some natural products to induce lysosomal-mediated cell death in neoplastic cells as a way to kill them more specifically than conventional therapies. This list is by no means exhaustive. We postulate mechanisms to explain lysosomal membrane permeabilization and its role in triggering cell death in cancer cells.
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spelling pubmed-86245332021-11-27 Natural Products Induce Lysosomal Membrane Permeabilization as an Anticancer Strategy Halaby, Reginald Medicines (Basel) Review Cancer is a global health and economic issue. The majority of anticancer therapies become ineffective due to frequent genomic turnover and chemoresistance. Furthermore, chemotherapy and radiation are non-specific, killing all rapidly dividing cells including healthy cells. In this review, we examine the ability of some natural products to induce lysosomal-mediated cell death in neoplastic cells as a way to kill them more specifically than conventional therapies. This list is by no means exhaustive. We postulate mechanisms to explain lysosomal membrane permeabilization and its role in triggering cell death in cancer cells. MDPI 2021-11-10 /pmc/articles/PMC8624533/ /pubmed/34822366 http://dx.doi.org/10.3390/medicines8110069 Text en © 2021 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Halaby, Reginald
Natural Products Induce Lysosomal Membrane Permeabilization as an Anticancer Strategy
title Natural Products Induce Lysosomal Membrane Permeabilization as an Anticancer Strategy
title_full Natural Products Induce Lysosomal Membrane Permeabilization as an Anticancer Strategy
title_fullStr Natural Products Induce Lysosomal Membrane Permeabilization as an Anticancer Strategy
title_full_unstemmed Natural Products Induce Lysosomal Membrane Permeabilization as an Anticancer Strategy
title_short Natural Products Induce Lysosomal Membrane Permeabilization as an Anticancer Strategy
title_sort natural products induce lysosomal membrane permeabilization as an anticancer strategy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624533/
https://www.ncbi.nlm.nih.gov/pubmed/34822366
http://dx.doi.org/10.3390/medicines8110069
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