Molecular Mechanisms of Retinal Pigment Epithelium Dysfunction in Age-Related Macular Degeneration

The retinal pigment epithelium (RPE), situated upon Bruch’s membrane, plays multiple roles in the ocular system by interacting with photoreceptors and. Therefore, dysfunction of the RPE causes diseases related to vision loss, such as age-related macular degeneration (AMD). Despite AMD being a global...

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Detalles Bibliográficos
Autores principales: Kim, Jongmin, Lee, Yeo Jin, Won, Jae Yon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624542/
https://www.ncbi.nlm.nih.gov/pubmed/34830181
http://dx.doi.org/10.3390/ijms222212298
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author Kim, Jongmin
Lee, Yeo Jin
Won, Jae Yon
author_facet Kim, Jongmin
Lee, Yeo Jin
Won, Jae Yon
author_sort Kim, Jongmin
collection PubMed
description The retinal pigment epithelium (RPE), situated upon Bruch’s membrane, plays multiple roles in the ocular system by interacting with photoreceptors and. Therefore, dysfunction of the RPE causes diseases related to vision loss, such as age-related macular degeneration (AMD). Despite AMD being a global cause of blindness, the pathogenesis remains unclear. Understanding the pathogenesis of AMD is the first step for its prevention and treatment. This review summarizes the common pathways of RPE dysfunction and their effect in AMD. Potential treatment strategies for AMD based on targeting the RPE have also been discussed.
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spelling pubmed-86245422021-11-27 Molecular Mechanisms of Retinal Pigment Epithelium Dysfunction in Age-Related Macular Degeneration Kim, Jongmin Lee, Yeo Jin Won, Jae Yon Int J Mol Sci Review The retinal pigment epithelium (RPE), situated upon Bruch’s membrane, plays multiple roles in the ocular system by interacting with photoreceptors and. Therefore, dysfunction of the RPE causes diseases related to vision loss, such as age-related macular degeneration (AMD). Despite AMD being a global cause of blindness, the pathogenesis remains unclear. Understanding the pathogenesis of AMD is the first step for its prevention and treatment. This review summarizes the common pathways of RPE dysfunction and their effect in AMD. Potential treatment strategies for AMD based on targeting the RPE have also been discussed. MDPI 2021-11-14 /pmc/articles/PMC8624542/ /pubmed/34830181 http://dx.doi.org/10.3390/ijms222212298 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kim, Jongmin
Lee, Yeo Jin
Won, Jae Yon
Molecular Mechanisms of Retinal Pigment Epithelium Dysfunction in Age-Related Macular Degeneration
title Molecular Mechanisms of Retinal Pigment Epithelium Dysfunction in Age-Related Macular Degeneration
title_full Molecular Mechanisms of Retinal Pigment Epithelium Dysfunction in Age-Related Macular Degeneration
title_fullStr Molecular Mechanisms of Retinal Pigment Epithelium Dysfunction in Age-Related Macular Degeneration
title_full_unstemmed Molecular Mechanisms of Retinal Pigment Epithelium Dysfunction in Age-Related Macular Degeneration
title_short Molecular Mechanisms of Retinal Pigment Epithelium Dysfunction in Age-Related Macular Degeneration
title_sort molecular mechanisms of retinal pigment epithelium dysfunction in age-related macular degeneration
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624542/
https://www.ncbi.nlm.nih.gov/pubmed/34830181
http://dx.doi.org/10.3390/ijms222212298
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