Engineering of Cytolethal Distending Toxin B by Its Reducing Immunogenicity and Maintaining Stability as a New Drug Candidate for Tumor Therapy; an In Silico Study

The cytolethal distending toxin (CDT), Haemophilus ducreyi, is one of the bacterial toxins that have recently been considered for targeted therapies, especially in cancer therapies. CDT is an A-B2 exotoxin. Its catalytic subunit (CdtB) is capable of inducing DNA double strand breaks, cell cycle arre...

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Detalles Bibliográficos
Autores principales: Keshtvarz, Maryam, Mahboobi, Mahdieh, Kieliszek, Marek, Miecznikowski, Antoni, Sedighian, Hamid, Rezaei, Milad, Haghighi, Mohammad Ali, Zareh, Zahra, Rezaei, Ehsan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624547/
https://www.ncbi.nlm.nih.gov/pubmed/34822569
http://dx.doi.org/10.3390/toxins13110785

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