Cargando…

Phytochemistry, Pharmacology, and Nutraceutical Profile of Carissa Species: An Updated Review

Carissa, a genus of the Apocynaceae family, consists of evergreen species, such as shrubs as well as small trees that are native to Asia, Africa, and Oceania’s subtropical and tropical regions. Most of the Carissa species are traditionally used to treat various diseases, such as chest pain, headache...

Descripción completa

Detalles Bibliográficos
Autores principales: Dhatwalia, Jyoti, Kumari, Amita, Verma, Rachna, Upadhyay, Navneet, Guleria, Ishita, Lal, Sohan, Thakur, Shabnam, Gudeta, Kasahun, Kumar, Vikas, Chao, Jane C.-J., Sharma, Somesh, Kumar, Ashwani, Manicum, Amanda-Lee Ezra, Lorenzo, José M., Amarowicz, Ryszard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624575/
https://www.ncbi.nlm.nih.gov/pubmed/34834102
http://dx.doi.org/10.3390/molecules26227010
_version_ 1784606208051642368
author Dhatwalia, Jyoti
Kumari, Amita
Verma, Rachna
Upadhyay, Navneet
Guleria, Ishita
Lal, Sohan
Thakur, Shabnam
Gudeta, Kasahun
Kumar, Vikas
Chao, Jane C.-J.
Sharma, Somesh
Kumar, Ashwani
Manicum, Amanda-Lee Ezra
Lorenzo, José M.
Amarowicz, Ryszard
author_facet Dhatwalia, Jyoti
Kumari, Amita
Verma, Rachna
Upadhyay, Navneet
Guleria, Ishita
Lal, Sohan
Thakur, Shabnam
Gudeta, Kasahun
Kumar, Vikas
Chao, Jane C.-J.
Sharma, Somesh
Kumar, Ashwani
Manicum, Amanda-Lee Ezra
Lorenzo, José M.
Amarowicz, Ryszard
author_sort Dhatwalia, Jyoti
collection PubMed
description Carissa, a genus of the Apocynaceae family, consists of evergreen species, such as shrubs as well as small trees that are native to Asia, Africa, and Oceania’s subtropical and tropical regions. Most of the Carissa species are traditionally used to treat various diseases, such as chest pain, headaches, gonorrhoea, rheumatism, syphilis, oedema, rabies, stomach pain, hepatitis, cardiac diseases, and asthma. The pharmacological studies on Carissa species revealed its antioxidant, antimicrobial, anticancer, cardioprotective, antipyretic, analgesic, wound healing, anticonvulsant, antiarthritic, adaptogenic, anti-inflammatory, and antidiabetic activities, thus validating its use in indigenous medicine systems. The review article summarised the comprehensive literature available, including morphology, indigenous uses, bioactive composition, nutraceutical, and pharmacological activities of Carissa species. A total of 155 research papers were cited in this review article. The Carissa fruits are rich in dietary fibre, lipids, proteins, carbohydrates, vitamin C, and macro- and micro-elements. A total of 121 compounds (35 polyphenols (flavonoids and phenolic acids), 30 lignans, 41 terpenoids, 7 steroids, 2 coumarins, and 6 cardiac glycosides) have been extracted from C. spinarum, C. carandas, and C. macrocarpa. Among all chemical constituents, lupeol, carissol, naringin, carisssone, scopoletin, carissaeduloside A, D, J, carandinol, sarhamnoloside, carissanol, olivil, carinol, 3β-hydroxyolean-11-en-28,13β-oilde, ursolic acid, and carissone are the key bioactive constituents responsible for pharmacological activities of genus Carissa. The gathered ethnopharmacological information in the review will help to understand the therapeutic relevance of Carissa as well as paving a way for further exploration in the discovery of novel plant-based drugs.
format Online
Article
Text
id pubmed-8624575
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-86245752021-11-27 Phytochemistry, Pharmacology, and Nutraceutical Profile of Carissa Species: An Updated Review Dhatwalia, Jyoti Kumari, Amita Verma, Rachna Upadhyay, Navneet Guleria, Ishita Lal, Sohan Thakur, Shabnam Gudeta, Kasahun Kumar, Vikas Chao, Jane C.-J. Sharma, Somesh Kumar, Ashwani Manicum, Amanda-Lee Ezra Lorenzo, José M. Amarowicz, Ryszard Molecules Review Carissa, a genus of the Apocynaceae family, consists of evergreen species, such as shrubs as well as small trees that are native to Asia, Africa, and Oceania’s subtropical and tropical regions. Most of the Carissa species are traditionally used to treat various diseases, such as chest pain, headaches, gonorrhoea, rheumatism, syphilis, oedema, rabies, stomach pain, hepatitis, cardiac diseases, and asthma. The pharmacological studies on Carissa species revealed its antioxidant, antimicrobial, anticancer, cardioprotective, antipyretic, analgesic, wound healing, anticonvulsant, antiarthritic, adaptogenic, anti-inflammatory, and antidiabetic activities, thus validating its use in indigenous medicine systems. The review article summarised the comprehensive literature available, including morphology, indigenous uses, bioactive composition, nutraceutical, and pharmacological activities of Carissa species. A total of 155 research papers were cited in this review article. The Carissa fruits are rich in dietary fibre, lipids, proteins, carbohydrates, vitamin C, and macro- and micro-elements. A total of 121 compounds (35 polyphenols (flavonoids and phenolic acids), 30 lignans, 41 terpenoids, 7 steroids, 2 coumarins, and 6 cardiac glycosides) have been extracted from C. spinarum, C. carandas, and C. macrocarpa. Among all chemical constituents, lupeol, carissol, naringin, carisssone, scopoletin, carissaeduloside A, D, J, carandinol, sarhamnoloside, carissanol, olivil, carinol, 3β-hydroxyolean-11-en-28,13β-oilde, ursolic acid, and carissone are the key bioactive constituents responsible for pharmacological activities of genus Carissa. The gathered ethnopharmacological information in the review will help to understand the therapeutic relevance of Carissa as well as paving a way for further exploration in the discovery of novel plant-based drugs. MDPI 2021-11-20 /pmc/articles/PMC8624575/ /pubmed/34834102 http://dx.doi.org/10.3390/molecules26227010 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Dhatwalia, Jyoti
Kumari, Amita
Verma, Rachna
Upadhyay, Navneet
Guleria, Ishita
Lal, Sohan
Thakur, Shabnam
Gudeta, Kasahun
Kumar, Vikas
Chao, Jane C.-J.
Sharma, Somesh
Kumar, Ashwani
Manicum, Amanda-Lee Ezra
Lorenzo, José M.
Amarowicz, Ryszard
Phytochemistry, Pharmacology, and Nutraceutical Profile of Carissa Species: An Updated Review
title Phytochemistry, Pharmacology, and Nutraceutical Profile of Carissa Species: An Updated Review
title_full Phytochemistry, Pharmacology, and Nutraceutical Profile of Carissa Species: An Updated Review
title_fullStr Phytochemistry, Pharmacology, and Nutraceutical Profile of Carissa Species: An Updated Review
title_full_unstemmed Phytochemistry, Pharmacology, and Nutraceutical Profile of Carissa Species: An Updated Review
title_short Phytochemistry, Pharmacology, and Nutraceutical Profile of Carissa Species: An Updated Review
title_sort phytochemistry, pharmacology, and nutraceutical profile of carissa species: an updated review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624575/
https://www.ncbi.nlm.nih.gov/pubmed/34834102
http://dx.doi.org/10.3390/molecules26227010
work_keys_str_mv AT dhatwaliajyoti phytochemistrypharmacologyandnutraceuticalprofileofcarissaspeciesanupdatedreview
AT kumariamita phytochemistrypharmacologyandnutraceuticalprofileofcarissaspeciesanupdatedreview
AT vermarachna phytochemistrypharmacologyandnutraceuticalprofileofcarissaspeciesanupdatedreview
AT upadhyaynavneet phytochemistrypharmacologyandnutraceuticalprofileofcarissaspeciesanupdatedreview
AT guleriaishita phytochemistrypharmacologyandnutraceuticalprofileofcarissaspeciesanupdatedreview
AT lalsohan phytochemistrypharmacologyandnutraceuticalprofileofcarissaspeciesanupdatedreview
AT thakurshabnam phytochemistrypharmacologyandnutraceuticalprofileofcarissaspeciesanupdatedreview
AT gudetakasahun phytochemistrypharmacologyandnutraceuticalprofileofcarissaspeciesanupdatedreview
AT kumarvikas phytochemistrypharmacologyandnutraceuticalprofileofcarissaspeciesanupdatedreview
AT chaojanecj phytochemistrypharmacologyandnutraceuticalprofileofcarissaspeciesanupdatedreview
AT sharmasomesh phytochemistrypharmacologyandnutraceuticalprofileofcarissaspeciesanupdatedreview
AT kumarashwani phytochemistrypharmacologyandnutraceuticalprofileofcarissaspeciesanupdatedreview
AT manicumamandaleeezra phytochemistrypharmacologyandnutraceuticalprofileofcarissaspeciesanupdatedreview
AT lorenzojosem phytochemistrypharmacologyandnutraceuticalprofileofcarissaspeciesanupdatedreview
AT amarowiczryszard phytochemistrypharmacologyandnutraceuticalprofileofcarissaspeciesanupdatedreview