Cargando…
Acetylenic Synthetic Betulin Derivatives Inhibit Akt and Erk Kinases Activity, Trigger Apoptosis and Suppress Proliferation of Neuroblastoma and Rhabdomyosarcoma Cell Lines
Neuroblastoma (NB) and rhabdomyosarcoma (RMS), the most common pediatric extracranial solid tumors, still represent an important clinical challenge since no effective treatment is available for metastatic and recurrent disease. Hence, there is an urgent need for the development of new chemotherapeut...
Autores principales: | Król, Sylwia K., Bębenek, Ewa, Dmoszyńska-Graniczka, Magdalena, Sławińska-Brych, Adrianna, Boryczka, Stanisław, Stepulak, Andrzej |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624615/ https://www.ncbi.nlm.nih.gov/pubmed/34830180 http://dx.doi.org/10.3390/ijms222212299 |
Ejemplares similares
-
New acetylenic derivatives of betulin and betulone,
synthesis and cytotoxic activity
por: Bębenek, Ewa, et al.
Publicado: (2016) -
Synthesis, Structure and Cytotoxic Activity of New Acetylenic Derivatives of Betulin
por: Boryczka, Stanisław, et al.
Publicado: (2013) -
Application of TLC for Evaluation of the Lipophilicity of Newly Synthetized Esters: Betulin Derivatives
por: Bober, Katarzyna, et al.
Publicado: (2019) -
Anticancer Activity of the Acetylenic Derivative of Betulin Phosphate Involves Induction of Necrotic-Like Death in Breast Cancer Cells In Vitro
por: Orchel, Arkadiusz, et al.
Publicado: (2021) -
Biological Activity and In Silico Study of 3-Modified Derivatives of Betulin and Betulinic Aldehyde
por: Bębenek, Ewa, et al.
Publicado: (2019)