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Novel Multimodal Management of Post-Partum Synchronous Metastatic Pulmonary EBV-Associated Lymphoepithelioma-Like Carcinoma (LELC)—A Case Report

Primary Epstein-Barr-Virus (EBV)-associated pulmonary lymphoepithelioma-like carcinoma (LELC) is an aggressive rare cancer. Higher incidences have been observed in Asian sub-populations. Multimodal treatment paradigms have emerged as promising novel strategies in the management of advanced NSCLC. In...

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Autores principales: Pazos, Montserrat, Eze, Chukwuka, Kahnert, Kathrin, Delius, Maria, Tufman, Amanda, Alba-Alejandre, Irene, Unterrainer, Marcus, Neumann, Jens, Kirchner, Thomas, Manapov, Farkhad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624618/
https://www.ncbi.nlm.nih.gov/pubmed/34829420
http://dx.doi.org/10.3390/diagnostics11112072
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author Pazos, Montserrat
Eze, Chukwuka
Kahnert, Kathrin
Delius, Maria
Tufman, Amanda
Alba-Alejandre, Irene
Unterrainer, Marcus
Neumann, Jens
Kirchner, Thomas
Manapov, Farkhad
author_facet Pazos, Montserrat
Eze, Chukwuka
Kahnert, Kathrin
Delius, Maria
Tufman, Amanda
Alba-Alejandre, Irene
Unterrainer, Marcus
Neumann, Jens
Kirchner, Thomas
Manapov, Farkhad
author_sort Pazos, Montserrat
collection PubMed
description Primary Epstein-Barr-Virus (EBV)-associated pulmonary lymphoepithelioma-like carcinoma (LELC) is an aggressive rare cancer. Higher incidences have been observed in Asian sub-populations. Multimodal treatment paradigms have emerged as promising novel strategies in the management of advanced NSCLC. In this report, we describe the case of a 34-year-old female patient of Asian origin with a post-partum initial diagnosis of pulmonary LELC. Multimodal treatment with chemoimmunotherapy and hypofractionated irradiation to the primary tumour and main metastatic sites led to a favourable response demonstrating that radiotherapy may potentially augment anti-tumour immunity. To the best of our knowledge, this is the first case report on this novel therapy strategy of multi-site hypofractionated radiotherapy and chemoimmunotherapy for metastatic pulmonary EBV-associated LELC.
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spelling pubmed-86246182021-11-27 Novel Multimodal Management of Post-Partum Synchronous Metastatic Pulmonary EBV-Associated Lymphoepithelioma-Like Carcinoma (LELC)—A Case Report Pazos, Montserrat Eze, Chukwuka Kahnert, Kathrin Delius, Maria Tufman, Amanda Alba-Alejandre, Irene Unterrainer, Marcus Neumann, Jens Kirchner, Thomas Manapov, Farkhad Diagnostics (Basel) Case Report Primary Epstein-Barr-Virus (EBV)-associated pulmonary lymphoepithelioma-like carcinoma (LELC) is an aggressive rare cancer. Higher incidences have been observed in Asian sub-populations. Multimodal treatment paradigms have emerged as promising novel strategies in the management of advanced NSCLC. In this report, we describe the case of a 34-year-old female patient of Asian origin with a post-partum initial diagnosis of pulmonary LELC. Multimodal treatment with chemoimmunotherapy and hypofractionated irradiation to the primary tumour and main metastatic sites led to a favourable response demonstrating that radiotherapy may potentially augment anti-tumour immunity. To the best of our knowledge, this is the first case report on this novel therapy strategy of multi-site hypofractionated radiotherapy and chemoimmunotherapy for metastatic pulmonary EBV-associated LELC. MDPI 2021-11-09 /pmc/articles/PMC8624618/ /pubmed/34829420 http://dx.doi.org/10.3390/diagnostics11112072 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Pazos, Montserrat
Eze, Chukwuka
Kahnert, Kathrin
Delius, Maria
Tufman, Amanda
Alba-Alejandre, Irene
Unterrainer, Marcus
Neumann, Jens
Kirchner, Thomas
Manapov, Farkhad
Novel Multimodal Management of Post-Partum Synchronous Metastatic Pulmonary EBV-Associated Lymphoepithelioma-Like Carcinoma (LELC)—A Case Report
title Novel Multimodal Management of Post-Partum Synchronous Metastatic Pulmonary EBV-Associated Lymphoepithelioma-Like Carcinoma (LELC)—A Case Report
title_full Novel Multimodal Management of Post-Partum Synchronous Metastatic Pulmonary EBV-Associated Lymphoepithelioma-Like Carcinoma (LELC)—A Case Report
title_fullStr Novel Multimodal Management of Post-Partum Synchronous Metastatic Pulmonary EBV-Associated Lymphoepithelioma-Like Carcinoma (LELC)—A Case Report
title_full_unstemmed Novel Multimodal Management of Post-Partum Synchronous Metastatic Pulmonary EBV-Associated Lymphoepithelioma-Like Carcinoma (LELC)—A Case Report
title_short Novel Multimodal Management of Post-Partum Synchronous Metastatic Pulmonary EBV-Associated Lymphoepithelioma-Like Carcinoma (LELC)—A Case Report
title_sort novel multimodal management of post-partum synchronous metastatic pulmonary ebv-associated lymphoepithelioma-like carcinoma (lelc)—a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624618/
https://www.ncbi.nlm.nih.gov/pubmed/34829420
http://dx.doi.org/10.3390/diagnostics11112072
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