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Novel Multimodal Management of Post-Partum Synchronous Metastatic Pulmonary EBV-Associated Lymphoepithelioma-Like Carcinoma (LELC)—A Case Report
Primary Epstein-Barr-Virus (EBV)-associated pulmonary lymphoepithelioma-like carcinoma (LELC) is an aggressive rare cancer. Higher incidences have been observed in Asian sub-populations. Multimodal treatment paradigms have emerged as promising novel strategies in the management of advanced NSCLC. In...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624618/ https://www.ncbi.nlm.nih.gov/pubmed/34829420 http://dx.doi.org/10.3390/diagnostics11112072 |
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author | Pazos, Montserrat Eze, Chukwuka Kahnert, Kathrin Delius, Maria Tufman, Amanda Alba-Alejandre, Irene Unterrainer, Marcus Neumann, Jens Kirchner, Thomas Manapov, Farkhad |
author_facet | Pazos, Montserrat Eze, Chukwuka Kahnert, Kathrin Delius, Maria Tufman, Amanda Alba-Alejandre, Irene Unterrainer, Marcus Neumann, Jens Kirchner, Thomas Manapov, Farkhad |
author_sort | Pazos, Montserrat |
collection | PubMed |
description | Primary Epstein-Barr-Virus (EBV)-associated pulmonary lymphoepithelioma-like carcinoma (LELC) is an aggressive rare cancer. Higher incidences have been observed in Asian sub-populations. Multimodal treatment paradigms have emerged as promising novel strategies in the management of advanced NSCLC. In this report, we describe the case of a 34-year-old female patient of Asian origin with a post-partum initial diagnosis of pulmonary LELC. Multimodal treatment with chemoimmunotherapy and hypofractionated irradiation to the primary tumour and main metastatic sites led to a favourable response demonstrating that radiotherapy may potentially augment anti-tumour immunity. To the best of our knowledge, this is the first case report on this novel therapy strategy of multi-site hypofractionated radiotherapy and chemoimmunotherapy for metastatic pulmonary EBV-associated LELC. |
format | Online Article Text |
id | pubmed-8624618 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86246182021-11-27 Novel Multimodal Management of Post-Partum Synchronous Metastatic Pulmonary EBV-Associated Lymphoepithelioma-Like Carcinoma (LELC)—A Case Report Pazos, Montserrat Eze, Chukwuka Kahnert, Kathrin Delius, Maria Tufman, Amanda Alba-Alejandre, Irene Unterrainer, Marcus Neumann, Jens Kirchner, Thomas Manapov, Farkhad Diagnostics (Basel) Case Report Primary Epstein-Barr-Virus (EBV)-associated pulmonary lymphoepithelioma-like carcinoma (LELC) is an aggressive rare cancer. Higher incidences have been observed in Asian sub-populations. Multimodal treatment paradigms have emerged as promising novel strategies in the management of advanced NSCLC. In this report, we describe the case of a 34-year-old female patient of Asian origin with a post-partum initial diagnosis of pulmonary LELC. Multimodal treatment with chemoimmunotherapy and hypofractionated irradiation to the primary tumour and main metastatic sites led to a favourable response demonstrating that radiotherapy may potentially augment anti-tumour immunity. To the best of our knowledge, this is the first case report on this novel therapy strategy of multi-site hypofractionated radiotherapy and chemoimmunotherapy for metastatic pulmonary EBV-associated LELC. MDPI 2021-11-09 /pmc/articles/PMC8624618/ /pubmed/34829420 http://dx.doi.org/10.3390/diagnostics11112072 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Case Report Pazos, Montserrat Eze, Chukwuka Kahnert, Kathrin Delius, Maria Tufman, Amanda Alba-Alejandre, Irene Unterrainer, Marcus Neumann, Jens Kirchner, Thomas Manapov, Farkhad Novel Multimodal Management of Post-Partum Synchronous Metastatic Pulmonary EBV-Associated Lymphoepithelioma-Like Carcinoma (LELC)—A Case Report |
title | Novel Multimodal Management of Post-Partum Synchronous Metastatic Pulmonary EBV-Associated Lymphoepithelioma-Like Carcinoma (LELC)—A Case Report |
title_full | Novel Multimodal Management of Post-Partum Synchronous Metastatic Pulmonary EBV-Associated Lymphoepithelioma-Like Carcinoma (LELC)—A Case Report |
title_fullStr | Novel Multimodal Management of Post-Partum Synchronous Metastatic Pulmonary EBV-Associated Lymphoepithelioma-Like Carcinoma (LELC)—A Case Report |
title_full_unstemmed | Novel Multimodal Management of Post-Partum Synchronous Metastatic Pulmonary EBV-Associated Lymphoepithelioma-Like Carcinoma (LELC)—A Case Report |
title_short | Novel Multimodal Management of Post-Partum Synchronous Metastatic Pulmonary EBV-Associated Lymphoepithelioma-Like Carcinoma (LELC)—A Case Report |
title_sort | novel multimodal management of post-partum synchronous metastatic pulmonary ebv-associated lymphoepithelioma-like carcinoma (lelc)—a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624618/ https://www.ncbi.nlm.nih.gov/pubmed/34829420 http://dx.doi.org/10.3390/diagnostics11112072 |
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