Cargando…

Riding the COVID Waves: Clinical Trends, Outcomes, and Remaining Pitfalls of the SARS-CoV-2 Pandemic: An Analysis of Two High-Incidence Periods at a Hospital in Northern Italy

Background. Italy was the first western country to face an uncontrolled outbreak of SARS-CoV-2 infection. The epidemic began in March 2020 within a context characterised by a general lack of knowledge about the disease. The first scientific evidence emerged months later, leading to treatment changes...

Descripción completa

Detalles Bibliográficos
Autores principales: Sartini, Marina, Del Puente, Filippo, Oliva, Martino, Carbone, Alessio, Blasi Vacca, Elisabetta, Parisini, Andrea, Boni, Silvia, Bobbio, Nicoletta, Feasi, Marcello, Battistella, Alessandra, Pontali, Emanuele, Cristina, Maria Luisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624682/
https://www.ncbi.nlm.nih.gov/pubmed/34830521
http://dx.doi.org/10.3390/jcm10225239
_version_ 1784606234166427648
author Sartini, Marina
Del Puente, Filippo
Oliva, Martino
Carbone, Alessio
Blasi Vacca, Elisabetta
Parisini, Andrea
Boni, Silvia
Bobbio, Nicoletta
Feasi, Marcello
Battistella, Alessandra
Pontali, Emanuele
Cristina, Maria Luisa
author_facet Sartini, Marina
Del Puente, Filippo
Oliva, Martino
Carbone, Alessio
Blasi Vacca, Elisabetta
Parisini, Andrea
Boni, Silvia
Bobbio, Nicoletta
Feasi, Marcello
Battistella, Alessandra
Pontali, Emanuele
Cristina, Maria Luisa
author_sort Sartini, Marina
collection PubMed
description Background. Italy was the first western country to face an uncontrolled outbreak of SARS-CoV-2 infection. The epidemic began in March 2020 within a context characterised by a general lack of knowledge about the disease. The first scientific evidence emerged months later, leading to treatment changes. The aim of our study was to evaluate the effects of these changes. Methods. Data from a hospital in Genoa, Italy, were analysed. Patients deceased from SARS-CoV-2 infection were selected. Data were compared by dividing patients into two cohorts: “phase A” (March–May 2020) and “phase B” (October–December 2020). Results. A total of 5142 patients were admitted. There were 274 SARS-CoV-2-related deaths (162 phase A and 112 phase B). No differences were observed in terms of demographics, presentation, or comorbidities. A significant increase was recorded in corticosteroid use. Mortality was 33.36% during phase A, falling to 21.71% during phase B. When subdividing the trend during the two phases by age, we found a difference in people aged 65–74 years. Conclusions. There is scarce evidence regarding treatment for SARS-CoV-2 (especially for severe infection). However, treatment changes improved the prognosis for people under the age of 75. The prognosis for older people remains poor, despite the improvements achieved.
format Online
Article
Text
id pubmed-8624682
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-86246822021-11-27 Riding the COVID Waves: Clinical Trends, Outcomes, and Remaining Pitfalls of the SARS-CoV-2 Pandemic: An Analysis of Two High-Incidence Periods at a Hospital in Northern Italy Sartini, Marina Del Puente, Filippo Oliva, Martino Carbone, Alessio Blasi Vacca, Elisabetta Parisini, Andrea Boni, Silvia Bobbio, Nicoletta Feasi, Marcello Battistella, Alessandra Pontali, Emanuele Cristina, Maria Luisa J Clin Med Article Background. Italy was the first western country to face an uncontrolled outbreak of SARS-CoV-2 infection. The epidemic began in March 2020 within a context characterised by a general lack of knowledge about the disease. The first scientific evidence emerged months later, leading to treatment changes. The aim of our study was to evaluate the effects of these changes. Methods. Data from a hospital in Genoa, Italy, were analysed. Patients deceased from SARS-CoV-2 infection were selected. Data were compared by dividing patients into two cohorts: “phase A” (March–May 2020) and “phase B” (October–December 2020). Results. A total of 5142 patients were admitted. There were 274 SARS-CoV-2-related deaths (162 phase A and 112 phase B). No differences were observed in terms of demographics, presentation, or comorbidities. A significant increase was recorded in corticosteroid use. Mortality was 33.36% during phase A, falling to 21.71% during phase B. When subdividing the trend during the two phases by age, we found a difference in people aged 65–74 years. Conclusions. There is scarce evidence regarding treatment for SARS-CoV-2 (especially for severe infection). However, treatment changes improved the prognosis for people under the age of 75. The prognosis for older people remains poor, despite the improvements achieved. MDPI 2021-11-11 /pmc/articles/PMC8624682/ /pubmed/34830521 http://dx.doi.org/10.3390/jcm10225239 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sartini, Marina
Del Puente, Filippo
Oliva, Martino
Carbone, Alessio
Blasi Vacca, Elisabetta
Parisini, Andrea
Boni, Silvia
Bobbio, Nicoletta
Feasi, Marcello
Battistella, Alessandra
Pontali, Emanuele
Cristina, Maria Luisa
Riding the COVID Waves: Clinical Trends, Outcomes, and Remaining Pitfalls of the SARS-CoV-2 Pandemic: An Analysis of Two High-Incidence Periods at a Hospital in Northern Italy
title Riding the COVID Waves: Clinical Trends, Outcomes, and Remaining Pitfalls of the SARS-CoV-2 Pandemic: An Analysis of Two High-Incidence Periods at a Hospital in Northern Italy
title_full Riding the COVID Waves: Clinical Trends, Outcomes, and Remaining Pitfalls of the SARS-CoV-2 Pandemic: An Analysis of Two High-Incidence Periods at a Hospital in Northern Italy
title_fullStr Riding the COVID Waves: Clinical Trends, Outcomes, and Remaining Pitfalls of the SARS-CoV-2 Pandemic: An Analysis of Two High-Incidence Periods at a Hospital in Northern Italy
title_full_unstemmed Riding the COVID Waves: Clinical Trends, Outcomes, and Remaining Pitfalls of the SARS-CoV-2 Pandemic: An Analysis of Two High-Incidence Periods at a Hospital in Northern Italy
title_short Riding the COVID Waves: Clinical Trends, Outcomes, and Remaining Pitfalls of the SARS-CoV-2 Pandemic: An Analysis of Two High-Incidence Periods at a Hospital in Northern Italy
title_sort riding the covid waves: clinical trends, outcomes, and remaining pitfalls of the sars-cov-2 pandemic: an analysis of two high-incidence periods at a hospital in northern italy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624682/
https://www.ncbi.nlm.nih.gov/pubmed/34830521
http://dx.doi.org/10.3390/jcm10225239
work_keys_str_mv AT sartinimarina ridingthecovidwavesclinicaltrendsoutcomesandremainingpitfallsofthesarscov2pandemicananalysisoftwohighincidenceperiodsatahospitalinnorthernitaly
AT delpuentefilippo ridingthecovidwavesclinicaltrendsoutcomesandremainingpitfallsofthesarscov2pandemicananalysisoftwohighincidenceperiodsatahospitalinnorthernitaly
AT olivamartino ridingthecovidwavesclinicaltrendsoutcomesandremainingpitfallsofthesarscov2pandemicananalysisoftwohighincidenceperiodsatahospitalinnorthernitaly
AT carbonealessio ridingthecovidwavesclinicaltrendsoutcomesandremainingpitfallsofthesarscov2pandemicananalysisoftwohighincidenceperiodsatahospitalinnorthernitaly
AT blasivaccaelisabetta ridingthecovidwavesclinicaltrendsoutcomesandremainingpitfallsofthesarscov2pandemicananalysisoftwohighincidenceperiodsatahospitalinnorthernitaly
AT parisiniandrea ridingthecovidwavesclinicaltrendsoutcomesandremainingpitfallsofthesarscov2pandemicananalysisoftwohighincidenceperiodsatahospitalinnorthernitaly
AT bonisilvia ridingthecovidwavesclinicaltrendsoutcomesandremainingpitfallsofthesarscov2pandemicananalysisoftwohighincidenceperiodsatahospitalinnorthernitaly
AT bobbionicoletta ridingthecovidwavesclinicaltrendsoutcomesandremainingpitfallsofthesarscov2pandemicananalysisoftwohighincidenceperiodsatahospitalinnorthernitaly
AT feasimarcello ridingthecovidwavesclinicaltrendsoutcomesandremainingpitfallsofthesarscov2pandemicananalysisoftwohighincidenceperiodsatahospitalinnorthernitaly
AT battistellaalessandra ridingthecovidwavesclinicaltrendsoutcomesandremainingpitfallsofthesarscov2pandemicananalysisoftwohighincidenceperiodsatahospitalinnorthernitaly
AT pontaliemanuele ridingthecovidwavesclinicaltrendsoutcomesandremainingpitfallsofthesarscov2pandemicananalysisoftwohighincidenceperiodsatahospitalinnorthernitaly
AT cristinamarialuisa ridingthecovidwavesclinicaltrendsoutcomesandremainingpitfallsofthesarscov2pandemicananalysisoftwohighincidenceperiodsatahospitalinnorthernitaly