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Blood stem cell PU.1 upregulation is a consequence of differentiation without fast autoregulation

Transcription factors (TFs) regulate cell fates, and their expression must be tightly regulated. Autoregulation is assumed to regulate many TFs’ own expression to control cell fates. Here, we manipulate and quantify the (auto)regulation of PU.1, a TF controlling hematopoietic stem and progenitor cel...

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Detalles Bibliográficos
Autores principales:	Ahmed, Nouraiz, Etzrodt, Martin, Dettinger, Philip, Kull, Tobias, Loeffler, Dirk, Hoppe, Philipp S., Chavez, James S., Zhang, Yang, Camargo Ortega, Germán, Hilsenbeck, Oliver, Nakajima, Hideaki, Pietras, Eric M., Schroeder, Timm
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2021
Materias:	Brief Definitive Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624737/ https://www.ncbi.nlm.nih.gov/pubmed/34817548 http://dx.doi.org/10.1084/jem.20202490

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