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Metalloproteinases in Endometrial Cancer—Are They Worth Measuring?
Endometrial cancer is one of the most common gynecological malignancies, yet the molecular mechanisms that lead to tumor development and progression are still not fully established. Matrix metalloproteinases (MMPs) are a group of enzymes that play an important role in carcinogenesis. They are protea...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624741/ https://www.ncbi.nlm.nih.gov/pubmed/34830354 http://dx.doi.org/10.3390/ijms222212472 |
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author | Michalczyk, Kaja Cymbaluk-Płoska, Aneta |
author_facet | Michalczyk, Kaja Cymbaluk-Płoska, Aneta |
author_sort | Michalczyk, Kaja |
collection | PubMed |
description | Endometrial cancer is one of the most common gynecological malignancies, yet the molecular mechanisms that lead to tumor development and progression are still not fully established. Matrix metalloproteinases (MMPs) are a group of enzymes that play an important role in carcinogenesis. They are proteases involved in the degradation of the extracellular matrix (ECM) that surrounds the tumor and the affected tissue allows cell detachment from the primary tumor causing local invasion and metastasis formation. Recent investigations demonstrate significantly increased metalloproteinase and metalloproteinase inhibitor levels in patients with endometrial cancer compared to those with normal endometrium. In this review, we aim to show their clinical significance and possible use in the diagnosis and treatment of patients with endometrial cancer. We have critically summarized and reviewed the research on the role of MMPs in endometrial cancer. |
format | Online Article Text |
id | pubmed-8624741 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86247412021-11-27 Metalloproteinases in Endometrial Cancer—Are They Worth Measuring? Michalczyk, Kaja Cymbaluk-Płoska, Aneta Int J Mol Sci Review Endometrial cancer is one of the most common gynecological malignancies, yet the molecular mechanisms that lead to tumor development and progression are still not fully established. Matrix metalloproteinases (MMPs) are a group of enzymes that play an important role in carcinogenesis. They are proteases involved in the degradation of the extracellular matrix (ECM) that surrounds the tumor and the affected tissue allows cell detachment from the primary tumor causing local invasion and metastasis formation. Recent investigations demonstrate significantly increased metalloproteinase and metalloproteinase inhibitor levels in patients with endometrial cancer compared to those with normal endometrium. In this review, we aim to show their clinical significance and possible use in the diagnosis and treatment of patients with endometrial cancer. We have critically summarized and reviewed the research on the role of MMPs in endometrial cancer. MDPI 2021-11-19 /pmc/articles/PMC8624741/ /pubmed/34830354 http://dx.doi.org/10.3390/ijms222212472 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Michalczyk, Kaja Cymbaluk-Płoska, Aneta Metalloproteinases in Endometrial Cancer—Are They Worth Measuring? |
title | Metalloproteinases in Endometrial Cancer—Are They Worth Measuring? |
title_full | Metalloproteinases in Endometrial Cancer—Are They Worth Measuring? |
title_fullStr | Metalloproteinases in Endometrial Cancer—Are They Worth Measuring? |
title_full_unstemmed | Metalloproteinases in Endometrial Cancer—Are They Worth Measuring? |
title_short | Metalloproteinases in Endometrial Cancer—Are They Worth Measuring? |
title_sort | metalloproteinases in endometrial cancer—are they worth measuring? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624741/ https://www.ncbi.nlm.nih.gov/pubmed/34830354 http://dx.doi.org/10.3390/ijms222212472 |
work_keys_str_mv | AT michalczykkaja metalloproteinasesinendometrialcanceraretheyworthmeasuring AT cymbalukpłoskaaneta metalloproteinasesinendometrialcanceraretheyworthmeasuring |