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Metalloproteinases in Endometrial Cancer—Are They Worth Measuring?

Endometrial cancer is one of the most common gynecological malignancies, yet the molecular mechanisms that lead to tumor development and progression are still not fully established. Matrix metalloproteinases (MMPs) are a group of enzymes that play an important role in carcinogenesis. They are protea...

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Autores principales: Michalczyk, Kaja, Cymbaluk-Płoska, Aneta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624741/
https://www.ncbi.nlm.nih.gov/pubmed/34830354
http://dx.doi.org/10.3390/ijms222212472
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author Michalczyk, Kaja
Cymbaluk-Płoska, Aneta
author_facet Michalczyk, Kaja
Cymbaluk-Płoska, Aneta
author_sort Michalczyk, Kaja
collection PubMed
description Endometrial cancer is one of the most common gynecological malignancies, yet the molecular mechanisms that lead to tumor development and progression are still not fully established. Matrix metalloproteinases (MMPs) are a group of enzymes that play an important role in carcinogenesis. They are proteases involved in the degradation of the extracellular matrix (ECM) that surrounds the tumor and the affected tissue allows cell detachment from the primary tumor causing local invasion and metastasis formation. Recent investigations demonstrate significantly increased metalloproteinase and metalloproteinase inhibitor levels in patients with endometrial cancer compared to those with normal endometrium. In this review, we aim to show their clinical significance and possible use in the diagnosis and treatment of patients with endometrial cancer. We have critically summarized and reviewed the research on the role of MMPs in endometrial cancer.
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spelling pubmed-86247412021-11-27 Metalloproteinases in Endometrial Cancer—Are They Worth Measuring? Michalczyk, Kaja Cymbaluk-Płoska, Aneta Int J Mol Sci Review Endometrial cancer is one of the most common gynecological malignancies, yet the molecular mechanisms that lead to tumor development and progression are still not fully established. Matrix metalloproteinases (MMPs) are a group of enzymes that play an important role in carcinogenesis. They are proteases involved in the degradation of the extracellular matrix (ECM) that surrounds the tumor and the affected tissue allows cell detachment from the primary tumor causing local invasion and metastasis formation. Recent investigations demonstrate significantly increased metalloproteinase and metalloproteinase inhibitor levels in patients with endometrial cancer compared to those with normal endometrium. In this review, we aim to show their clinical significance and possible use in the diagnosis and treatment of patients with endometrial cancer. We have critically summarized and reviewed the research on the role of MMPs in endometrial cancer. MDPI 2021-11-19 /pmc/articles/PMC8624741/ /pubmed/34830354 http://dx.doi.org/10.3390/ijms222212472 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Michalczyk, Kaja
Cymbaluk-Płoska, Aneta
Metalloproteinases in Endometrial Cancer—Are They Worth Measuring?
title Metalloproteinases in Endometrial Cancer—Are They Worth Measuring?
title_full Metalloproteinases in Endometrial Cancer—Are They Worth Measuring?
title_fullStr Metalloproteinases in Endometrial Cancer—Are They Worth Measuring?
title_full_unstemmed Metalloproteinases in Endometrial Cancer—Are They Worth Measuring?
title_short Metalloproteinases in Endometrial Cancer—Are They Worth Measuring?
title_sort metalloproteinases in endometrial cancer—are they worth measuring?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624741/
https://www.ncbi.nlm.nih.gov/pubmed/34830354
http://dx.doi.org/10.3390/ijms222212472
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