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Hydrogel, Electrospun and Composite Materials for Bone/Cartilage and Neural Tissue Engineering

Injuries of the bone/cartilage and central nervous system are still a serious socio-economic problem. They are an effect of diversified, difficult-to-access tissue structures as well as complex regeneration mechanisms. Currently, commercially available materials partially solve this problem, but the...

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Autores principales: Niemczyk-Soczynska, Beata, Zaszczyńska, Angelika, Zabielski, Konrad, Sajkiewicz, Pawel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624846/
https://www.ncbi.nlm.nih.gov/pubmed/34832300
http://dx.doi.org/10.3390/ma14226899
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author Niemczyk-Soczynska, Beata
Zaszczyńska, Angelika
Zabielski, Konrad
Sajkiewicz, Pawel
author_facet Niemczyk-Soczynska, Beata
Zaszczyńska, Angelika
Zabielski, Konrad
Sajkiewicz, Pawel
author_sort Niemczyk-Soczynska, Beata
collection PubMed
description Injuries of the bone/cartilage and central nervous system are still a serious socio-economic problem. They are an effect of diversified, difficult-to-access tissue structures as well as complex regeneration mechanisms. Currently, commercially available materials partially solve this problem, but they do not fulfill all of the bone/cartilage and neural tissue engineering requirements such as mechanical properties, biochemical cues or adequate biodegradation. There are still many things to do to provide complete restoration of injured tissues. Recent reports in bone/cartilage and neural tissue engineering give high hopes in designing scaffolds for complete tissue regeneration. This review thoroughly discusses the advantages and disadvantages of currently available commercial scaffolds and sheds new light on the designing of novel polymeric scaffolds composed of hydrogels, electrospun nanofibers, or hydrogels loaded with nano-additives.
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spelling pubmed-86248462021-11-27 Hydrogel, Electrospun and Composite Materials for Bone/Cartilage and Neural Tissue Engineering Niemczyk-Soczynska, Beata Zaszczyńska, Angelika Zabielski, Konrad Sajkiewicz, Pawel Materials (Basel) Review Injuries of the bone/cartilage and central nervous system are still a serious socio-economic problem. They are an effect of diversified, difficult-to-access tissue structures as well as complex regeneration mechanisms. Currently, commercially available materials partially solve this problem, but they do not fulfill all of the bone/cartilage and neural tissue engineering requirements such as mechanical properties, biochemical cues or adequate biodegradation. There are still many things to do to provide complete restoration of injured tissues. Recent reports in bone/cartilage and neural tissue engineering give high hopes in designing scaffolds for complete tissue regeneration. This review thoroughly discusses the advantages and disadvantages of currently available commercial scaffolds and sheds new light on the designing of novel polymeric scaffolds composed of hydrogels, electrospun nanofibers, or hydrogels loaded with nano-additives. MDPI 2021-11-15 /pmc/articles/PMC8624846/ /pubmed/34832300 http://dx.doi.org/10.3390/ma14226899 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Niemczyk-Soczynska, Beata
Zaszczyńska, Angelika
Zabielski, Konrad
Sajkiewicz, Pawel
Hydrogel, Electrospun and Composite Materials for Bone/Cartilage and Neural Tissue Engineering
title Hydrogel, Electrospun and Composite Materials for Bone/Cartilage and Neural Tissue Engineering
title_full Hydrogel, Electrospun and Composite Materials for Bone/Cartilage and Neural Tissue Engineering
title_fullStr Hydrogel, Electrospun and Composite Materials for Bone/Cartilage and Neural Tissue Engineering
title_full_unstemmed Hydrogel, Electrospun and Composite Materials for Bone/Cartilage and Neural Tissue Engineering
title_short Hydrogel, Electrospun and Composite Materials for Bone/Cartilage and Neural Tissue Engineering
title_sort hydrogel, electrospun and composite materials for bone/cartilage and neural tissue engineering
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624846/
https://www.ncbi.nlm.nih.gov/pubmed/34832300
http://dx.doi.org/10.3390/ma14226899
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