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Changing Features of COVID-19: Characteristics of Infections with the SARS-CoV-2 Delta (B.1.617.2) and Alpha (B.1.1.7) Variants in Southern Italy

Differences in the demographic and clinical characteristics of patients infected with the Alpha and Delta SARS-CoV-2 variants of concern in a large region of Southern Italy were assessed. Two cohorts of positive patients were compared. The Alpha group consisted of 11,135 subjects diagnosed between 2...

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Autores principales: Loconsole, Daniela, Centrone, Francesca, Morcavallo, Caterina, Campanella, Silvia, Accogli, Marisa, Sallustio, Anna, Peccarisi, Davide, Stufano, Angela, Lovreglio, Piero, Chironna, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624869/
https://www.ncbi.nlm.nih.gov/pubmed/34835285
http://dx.doi.org/10.3390/vaccines9111354
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author Loconsole, Daniela
Centrone, Francesca
Morcavallo, Caterina
Campanella, Silvia
Accogli, Marisa
Sallustio, Anna
Peccarisi, Davide
Stufano, Angela
Lovreglio, Piero
Chironna, Maria
author_facet Loconsole, Daniela
Centrone, Francesca
Morcavallo, Caterina
Campanella, Silvia
Accogli, Marisa
Sallustio, Anna
Peccarisi, Davide
Stufano, Angela
Lovreglio, Piero
Chironna, Maria
author_sort Loconsole, Daniela
collection PubMed
description Differences in the demographic and clinical characteristics of patients infected with the Alpha and Delta SARS-CoV-2 variants of concern in a large region of Southern Italy were assessed. Two cohorts of positive patients were compared. The Alpha group consisted of 11,135 subjects diagnosed between 21 March and 21 April 2021, and the Delta group consisted of 499 positive subjects diagnosed between 21 July and 21 August 2021. A descriptive and statistical analysis of the demographic and clinical characteristics of the two groups was performed. The proportion of patients with mild and moderate infections was significantly higher in the Delta than in the Alpha group (p < 0.001). In fully vaccinated patients, the proportion of symptomatic individuals was significantly higher in the Delta than in the Alpha group. The Delta group showed odds ratios of 3.08 (95% CI, 2.55–3.72) for symptomatic infection and 2.66 (95% CI, 1.76–3.94) for hospitalization. Improving COVID-19 vaccination rates is a priority, since infection with the SARS-CoV-2 Delta variant has a significant impact on patient outcomes. Additional targeted prevention strategies such as social distancing, the use of masks in indoor settings irrespective of vaccination status, and the use of a sanitary passport could be crucial to contain further spread of SARS-CoV-2 infection.
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spelling pubmed-86248692021-11-27 Changing Features of COVID-19: Characteristics of Infections with the SARS-CoV-2 Delta (B.1.617.2) and Alpha (B.1.1.7) Variants in Southern Italy Loconsole, Daniela Centrone, Francesca Morcavallo, Caterina Campanella, Silvia Accogli, Marisa Sallustio, Anna Peccarisi, Davide Stufano, Angela Lovreglio, Piero Chironna, Maria Vaccines (Basel) Article Differences in the demographic and clinical characteristics of patients infected with the Alpha and Delta SARS-CoV-2 variants of concern in a large region of Southern Italy were assessed. Two cohorts of positive patients were compared. The Alpha group consisted of 11,135 subjects diagnosed between 21 March and 21 April 2021, and the Delta group consisted of 499 positive subjects diagnosed between 21 July and 21 August 2021. A descriptive and statistical analysis of the demographic and clinical characteristics of the two groups was performed. The proportion of patients with mild and moderate infections was significantly higher in the Delta than in the Alpha group (p < 0.001). In fully vaccinated patients, the proportion of symptomatic individuals was significantly higher in the Delta than in the Alpha group. The Delta group showed odds ratios of 3.08 (95% CI, 2.55–3.72) for symptomatic infection and 2.66 (95% CI, 1.76–3.94) for hospitalization. Improving COVID-19 vaccination rates is a priority, since infection with the SARS-CoV-2 Delta variant has a significant impact on patient outcomes. Additional targeted prevention strategies such as social distancing, the use of masks in indoor settings irrespective of vaccination status, and the use of a sanitary passport could be crucial to contain further spread of SARS-CoV-2 infection. MDPI 2021-11-18 /pmc/articles/PMC8624869/ /pubmed/34835285 http://dx.doi.org/10.3390/vaccines9111354 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Loconsole, Daniela
Centrone, Francesca
Morcavallo, Caterina
Campanella, Silvia
Accogli, Marisa
Sallustio, Anna
Peccarisi, Davide
Stufano, Angela
Lovreglio, Piero
Chironna, Maria
Changing Features of COVID-19: Characteristics of Infections with the SARS-CoV-2 Delta (B.1.617.2) and Alpha (B.1.1.7) Variants in Southern Italy
title Changing Features of COVID-19: Characteristics of Infections with the SARS-CoV-2 Delta (B.1.617.2) and Alpha (B.1.1.7) Variants in Southern Italy
title_full Changing Features of COVID-19: Characteristics of Infections with the SARS-CoV-2 Delta (B.1.617.2) and Alpha (B.1.1.7) Variants in Southern Italy
title_fullStr Changing Features of COVID-19: Characteristics of Infections with the SARS-CoV-2 Delta (B.1.617.2) and Alpha (B.1.1.7) Variants in Southern Italy
title_full_unstemmed Changing Features of COVID-19: Characteristics of Infections with the SARS-CoV-2 Delta (B.1.617.2) and Alpha (B.1.1.7) Variants in Southern Italy
title_short Changing Features of COVID-19: Characteristics of Infections with the SARS-CoV-2 Delta (B.1.617.2) and Alpha (B.1.1.7) Variants in Southern Italy
title_sort changing features of covid-19: characteristics of infections with the sars-cov-2 delta (b.1.617.2) and alpha (b.1.1.7) variants in southern italy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624869/
https://www.ncbi.nlm.nih.gov/pubmed/34835285
http://dx.doi.org/10.3390/vaccines9111354
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