Cargando…
Changing Features of COVID-19: Characteristics of Infections with the SARS-CoV-2 Delta (B.1.617.2) and Alpha (B.1.1.7) Variants in Southern Italy
Differences in the demographic and clinical characteristics of patients infected with the Alpha and Delta SARS-CoV-2 variants of concern in a large region of Southern Italy were assessed. Two cohorts of positive patients were compared. The Alpha group consisted of 11,135 subjects diagnosed between 2...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624869/ https://www.ncbi.nlm.nih.gov/pubmed/34835285 http://dx.doi.org/10.3390/vaccines9111354 |
_version_ | 1784606279557185536 |
---|---|
author | Loconsole, Daniela Centrone, Francesca Morcavallo, Caterina Campanella, Silvia Accogli, Marisa Sallustio, Anna Peccarisi, Davide Stufano, Angela Lovreglio, Piero Chironna, Maria |
author_facet | Loconsole, Daniela Centrone, Francesca Morcavallo, Caterina Campanella, Silvia Accogli, Marisa Sallustio, Anna Peccarisi, Davide Stufano, Angela Lovreglio, Piero Chironna, Maria |
author_sort | Loconsole, Daniela |
collection | PubMed |
description | Differences in the demographic and clinical characteristics of patients infected with the Alpha and Delta SARS-CoV-2 variants of concern in a large region of Southern Italy were assessed. Two cohorts of positive patients were compared. The Alpha group consisted of 11,135 subjects diagnosed between 21 March and 21 April 2021, and the Delta group consisted of 499 positive subjects diagnosed between 21 July and 21 August 2021. A descriptive and statistical analysis of the demographic and clinical characteristics of the two groups was performed. The proportion of patients with mild and moderate infections was significantly higher in the Delta than in the Alpha group (p < 0.001). In fully vaccinated patients, the proportion of symptomatic individuals was significantly higher in the Delta than in the Alpha group. The Delta group showed odds ratios of 3.08 (95% CI, 2.55–3.72) for symptomatic infection and 2.66 (95% CI, 1.76–3.94) for hospitalization. Improving COVID-19 vaccination rates is a priority, since infection with the SARS-CoV-2 Delta variant has a significant impact on patient outcomes. Additional targeted prevention strategies such as social distancing, the use of masks in indoor settings irrespective of vaccination status, and the use of a sanitary passport could be crucial to contain further spread of SARS-CoV-2 infection. |
format | Online Article Text |
id | pubmed-8624869 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86248692021-11-27 Changing Features of COVID-19: Characteristics of Infections with the SARS-CoV-2 Delta (B.1.617.2) and Alpha (B.1.1.7) Variants in Southern Italy Loconsole, Daniela Centrone, Francesca Morcavallo, Caterina Campanella, Silvia Accogli, Marisa Sallustio, Anna Peccarisi, Davide Stufano, Angela Lovreglio, Piero Chironna, Maria Vaccines (Basel) Article Differences in the demographic and clinical characteristics of patients infected with the Alpha and Delta SARS-CoV-2 variants of concern in a large region of Southern Italy were assessed. Two cohorts of positive patients were compared. The Alpha group consisted of 11,135 subjects diagnosed between 21 March and 21 April 2021, and the Delta group consisted of 499 positive subjects diagnosed between 21 July and 21 August 2021. A descriptive and statistical analysis of the demographic and clinical characteristics of the two groups was performed. The proportion of patients with mild and moderate infections was significantly higher in the Delta than in the Alpha group (p < 0.001). In fully vaccinated patients, the proportion of symptomatic individuals was significantly higher in the Delta than in the Alpha group. The Delta group showed odds ratios of 3.08 (95% CI, 2.55–3.72) for symptomatic infection and 2.66 (95% CI, 1.76–3.94) for hospitalization. Improving COVID-19 vaccination rates is a priority, since infection with the SARS-CoV-2 Delta variant has a significant impact on patient outcomes. Additional targeted prevention strategies such as social distancing, the use of masks in indoor settings irrespective of vaccination status, and the use of a sanitary passport could be crucial to contain further spread of SARS-CoV-2 infection. MDPI 2021-11-18 /pmc/articles/PMC8624869/ /pubmed/34835285 http://dx.doi.org/10.3390/vaccines9111354 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Loconsole, Daniela Centrone, Francesca Morcavallo, Caterina Campanella, Silvia Accogli, Marisa Sallustio, Anna Peccarisi, Davide Stufano, Angela Lovreglio, Piero Chironna, Maria Changing Features of COVID-19: Characteristics of Infections with the SARS-CoV-2 Delta (B.1.617.2) and Alpha (B.1.1.7) Variants in Southern Italy |
title | Changing Features of COVID-19: Characteristics of Infections with the SARS-CoV-2 Delta (B.1.617.2) and Alpha (B.1.1.7) Variants in Southern Italy |
title_full | Changing Features of COVID-19: Characteristics of Infections with the SARS-CoV-2 Delta (B.1.617.2) and Alpha (B.1.1.7) Variants in Southern Italy |
title_fullStr | Changing Features of COVID-19: Characteristics of Infections with the SARS-CoV-2 Delta (B.1.617.2) and Alpha (B.1.1.7) Variants in Southern Italy |
title_full_unstemmed | Changing Features of COVID-19: Characteristics of Infections with the SARS-CoV-2 Delta (B.1.617.2) and Alpha (B.1.1.7) Variants in Southern Italy |
title_short | Changing Features of COVID-19: Characteristics of Infections with the SARS-CoV-2 Delta (B.1.617.2) and Alpha (B.1.1.7) Variants in Southern Italy |
title_sort | changing features of covid-19: characteristics of infections with the sars-cov-2 delta (b.1.617.2) and alpha (b.1.1.7) variants in southern italy |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624869/ https://www.ncbi.nlm.nih.gov/pubmed/34835285 http://dx.doi.org/10.3390/vaccines9111354 |
work_keys_str_mv | AT loconsoledaniela changingfeaturesofcovid19characteristicsofinfectionswiththesarscov2deltab16172andalphab117variantsinsouthernitaly AT centronefrancesca changingfeaturesofcovid19characteristicsofinfectionswiththesarscov2deltab16172andalphab117variantsinsouthernitaly AT morcavallocaterina changingfeaturesofcovid19characteristicsofinfectionswiththesarscov2deltab16172andalphab117variantsinsouthernitaly AT campanellasilvia changingfeaturesofcovid19characteristicsofinfectionswiththesarscov2deltab16172andalphab117variantsinsouthernitaly AT accoglimarisa changingfeaturesofcovid19characteristicsofinfectionswiththesarscov2deltab16172andalphab117variantsinsouthernitaly AT sallustioanna changingfeaturesofcovid19characteristicsofinfectionswiththesarscov2deltab16172andalphab117variantsinsouthernitaly AT peccarisidavide changingfeaturesofcovid19characteristicsofinfectionswiththesarscov2deltab16172andalphab117variantsinsouthernitaly AT stufanoangela changingfeaturesofcovid19characteristicsofinfectionswiththesarscov2deltab16172andalphab117variantsinsouthernitaly AT lovregliopiero changingfeaturesofcovid19characteristicsofinfectionswiththesarscov2deltab16172andalphab117variantsinsouthernitaly AT chironnamaria changingfeaturesofcovid19characteristicsofinfectionswiththesarscov2deltab16172andalphab117variantsinsouthernitaly |