Cargando…
Quantitative Magnetic Resonance Imaging in Perianal Crohn’s Disease at 1.5 and 3.0 T: A Feasibility Study
Perianal Crohn’s Disease (pCD) is a common manifestation of Crohn’s Disease. Absence of reliable disease measures makes disease monitoring unreliable. Qualitative MRI has been increasingly used for diagnosing and monitoring pCD and has shown potential for assessing response to treatment. Quantitativ...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624877/ https://www.ncbi.nlm.nih.gov/pubmed/34829482 http://dx.doi.org/10.3390/diagnostics11112135 |
_version_ | 1784606281160458240 |
---|---|
author | Alyami, Ali Hoad, Caroline L. Tench, Christopher Bannur, Uday Clarke, Christopher Latief, Khalid Argyriou, Konstantinos Lobo, Alan Lung, Philip Baldwin-Cleland, Rachel Sahnan, Kapil Hart, Ailsa Limdi, Jimmy K. Mclaughlin, John Atkinson, David Parker, Geoffrey J. M. O’Connor, James P. B. Little, Ross A. Gowland, Penny A. Moran, Gordon W. |
author_facet | Alyami, Ali Hoad, Caroline L. Tench, Christopher Bannur, Uday Clarke, Christopher Latief, Khalid Argyriou, Konstantinos Lobo, Alan Lung, Philip Baldwin-Cleland, Rachel Sahnan, Kapil Hart, Ailsa Limdi, Jimmy K. Mclaughlin, John Atkinson, David Parker, Geoffrey J. M. O’Connor, James P. B. Little, Ross A. Gowland, Penny A. Moran, Gordon W. |
author_sort | Alyami, Ali |
collection | PubMed |
description | Perianal Crohn’s Disease (pCD) is a common manifestation of Crohn’s Disease. Absence of reliable disease measures makes disease monitoring unreliable. Qualitative MRI has been increasingly used for diagnosing and monitoring pCD and has shown potential for assessing response to treatment. Quantitative MRI sequences, such as diffusion-weighted imaging (DWI), dynamic contrast enhancement (DCE) and magnetisation transfer (MT), along with T2 relaxometry, offer opportunities to improve diagnostic capability. Quantitative MRI sequences (DWI, DCE, MT and T2) were used in a cohort of 25 pCD patients before and 12 weeks after biological therapy at two different field strengths (1.5 and 3 T). Disease activity was measured with the Perianal Crohn’s Disease Activity index (PDAI) and serum C-reactive protein (CRP). Diseased tissue areas on MRI were defined by a radiologist. A baseline model to predict outcome at 12 weeks was developed. No differences were seen in the quantitative MR measured in the diseased tissue regions from baseline to 12 weeks; however, PDAI and CRP decreased. Baseline PDAI, CRP, T2 relaxometry and surgical history were found to have a moderate ability to predict response after 12 weeks of biological treatment. Validation in larger cohorts with MRI and clinical measures are needed in order to further develop the model. |
format | Online Article Text |
id | pubmed-8624877 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86248772021-11-27 Quantitative Magnetic Resonance Imaging in Perianal Crohn’s Disease at 1.5 and 3.0 T: A Feasibility Study Alyami, Ali Hoad, Caroline L. Tench, Christopher Bannur, Uday Clarke, Christopher Latief, Khalid Argyriou, Konstantinos Lobo, Alan Lung, Philip Baldwin-Cleland, Rachel Sahnan, Kapil Hart, Ailsa Limdi, Jimmy K. Mclaughlin, John Atkinson, David Parker, Geoffrey J. M. O’Connor, James P. B. Little, Ross A. Gowland, Penny A. Moran, Gordon W. Diagnostics (Basel) Article Perianal Crohn’s Disease (pCD) is a common manifestation of Crohn’s Disease. Absence of reliable disease measures makes disease monitoring unreliable. Qualitative MRI has been increasingly used for diagnosing and monitoring pCD and has shown potential for assessing response to treatment. Quantitative MRI sequences, such as diffusion-weighted imaging (DWI), dynamic contrast enhancement (DCE) and magnetisation transfer (MT), along with T2 relaxometry, offer opportunities to improve diagnostic capability. Quantitative MRI sequences (DWI, DCE, MT and T2) were used in a cohort of 25 pCD patients before and 12 weeks after biological therapy at two different field strengths (1.5 and 3 T). Disease activity was measured with the Perianal Crohn’s Disease Activity index (PDAI) and serum C-reactive protein (CRP). Diseased tissue areas on MRI were defined by a radiologist. A baseline model to predict outcome at 12 weeks was developed. No differences were seen in the quantitative MR measured in the diseased tissue regions from baseline to 12 weeks; however, PDAI and CRP decreased. Baseline PDAI, CRP, T2 relaxometry and surgical history were found to have a moderate ability to predict response after 12 weeks of biological treatment. Validation in larger cohorts with MRI and clinical measures are needed in order to further develop the model. MDPI 2021-11-17 /pmc/articles/PMC8624877/ /pubmed/34829482 http://dx.doi.org/10.3390/diagnostics11112135 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Alyami, Ali Hoad, Caroline L. Tench, Christopher Bannur, Uday Clarke, Christopher Latief, Khalid Argyriou, Konstantinos Lobo, Alan Lung, Philip Baldwin-Cleland, Rachel Sahnan, Kapil Hart, Ailsa Limdi, Jimmy K. Mclaughlin, John Atkinson, David Parker, Geoffrey J. M. O’Connor, James P. B. Little, Ross A. Gowland, Penny A. Moran, Gordon W. Quantitative Magnetic Resonance Imaging in Perianal Crohn’s Disease at 1.5 and 3.0 T: A Feasibility Study |
title | Quantitative Magnetic Resonance Imaging in Perianal Crohn’s Disease at 1.5 and 3.0 T: A Feasibility Study |
title_full | Quantitative Magnetic Resonance Imaging in Perianal Crohn’s Disease at 1.5 and 3.0 T: A Feasibility Study |
title_fullStr | Quantitative Magnetic Resonance Imaging in Perianal Crohn’s Disease at 1.5 and 3.0 T: A Feasibility Study |
title_full_unstemmed | Quantitative Magnetic Resonance Imaging in Perianal Crohn’s Disease at 1.5 and 3.0 T: A Feasibility Study |
title_short | Quantitative Magnetic Resonance Imaging in Perianal Crohn’s Disease at 1.5 and 3.0 T: A Feasibility Study |
title_sort | quantitative magnetic resonance imaging in perianal crohn’s disease at 1.5 and 3.0 t: a feasibility study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624877/ https://www.ncbi.nlm.nih.gov/pubmed/34829482 http://dx.doi.org/10.3390/diagnostics11112135 |
work_keys_str_mv | AT alyamiali quantitativemagneticresonanceimaginginperianalcrohnsdiseaseat15and30tafeasibilitystudy AT hoadcarolinel quantitativemagneticresonanceimaginginperianalcrohnsdiseaseat15and30tafeasibilitystudy AT tenchchristopher quantitativemagneticresonanceimaginginperianalcrohnsdiseaseat15and30tafeasibilitystudy AT bannuruday quantitativemagneticresonanceimaginginperianalcrohnsdiseaseat15and30tafeasibilitystudy AT clarkechristopher quantitativemagneticresonanceimaginginperianalcrohnsdiseaseat15and30tafeasibilitystudy AT latiefkhalid quantitativemagneticresonanceimaginginperianalcrohnsdiseaseat15and30tafeasibilitystudy AT argyrioukonstantinos quantitativemagneticresonanceimaginginperianalcrohnsdiseaseat15and30tafeasibilitystudy AT loboalan quantitativemagneticresonanceimaginginperianalcrohnsdiseaseat15and30tafeasibilitystudy AT lungphilip quantitativemagneticresonanceimaginginperianalcrohnsdiseaseat15and30tafeasibilitystudy AT baldwinclelandrachel quantitativemagneticresonanceimaginginperianalcrohnsdiseaseat15and30tafeasibilitystudy AT sahnankapil quantitativemagneticresonanceimaginginperianalcrohnsdiseaseat15and30tafeasibilitystudy AT hartailsa quantitativemagneticresonanceimaginginperianalcrohnsdiseaseat15and30tafeasibilitystudy AT limdijimmyk quantitativemagneticresonanceimaginginperianalcrohnsdiseaseat15and30tafeasibilitystudy AT mclaughlinjohn quantitativemagneticresonanceimaginginperianalcrohnsdiseaseat15and30tafeasibilitystudy AT atkinsondavid quantitativemagneticresonanceimaginginperianalcrohnsdiseaseat15and30tafeasibilitystudy AT parkergeoffreyjm quantitativemagneticresonanceimaginginperianalcrohnsdiseaseat15and30tafeasibilitystudy AT oconnorjamespb quantitativemagneticresonanceimaginginperianalcrohnsdiseaseat15and30tafeasibilitystudy AT littlerossa quantitativemagneticresonanceimaginginperianalcrohnsdiseaseat15and30tafeasibilitystudy AT gowlandpennya quantitativemagneticresonanceimaginginperianalcrohnsdiseaseat15and30tafeasibilitystudy AT morangordonw quantitativemagneticresonanceimaginginperianalcrohnsdiseaseat15and30tafeasibilitystudy |