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Quantitative Magnetic Resonance Imaging in Perianal Crohn’s Disease at 1.5 and 3.0 T: A Feasibility Study

Perianal Crohn’s Disease (pCD) is a common manifestation of Crohn’s Disease. Absence of reliable disease measures makes disease monitoring unreliable. Qualitative MRI has been increasingly used for diagnosing and monitoring pCD and has shown potential for assessing response to treatment. Quantitativ...

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Autores principales: Alyami, Ali, Hoad, Caroline L., Tench, Christopher, Bannur, Uday, Clarke, Christopher, Latief, Khalid, Argyriou, Konstantinos, Lobo, Alan, Lung, Philip, Baldwin-Cleland, Rachel, Sahnan, Kapil, Hart, Ailsa, Limdi, Jimmy K., Mclaughlin, John, Atkinson, David, Parker, Geoffrey J. M., O’Connor, James P. B., Little, Ross A., Gowland, Penny A., Moran, Gordon W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624877/
https://www.ncbi.nlm.nih.gov/pubmed/34829482
http://dx.doi.org/10.3390/diagnostics11112135
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author Alyami, Ali
Hoad, Caroline L.
Tench, Christopher
Bannur, Uday
Clarke, Christopher
Latief, Khalid
Argyriou, Konstantinos
Lobo, Alan
Lung, Philip
Baldwin-Cleland, Rachel
Sahnan, Kapil
Hart, Ailsa
Limdi, Jimmy K.
Mclaughlin, John
Atkinson, David
Parker, Geoffrey J. M.
O’Connor, James P. B.
Little, Ross A.
Gowland, Penny A.
Moran, Gordon W.
author_facet Alyami, Ali
Hoad, Caroline L.
Tench, Christopher
Bannur, Uday
Clarke, Christopher
Latief, Khalid
Argyriou, Konstantinos
Lobo, Alan
Lung, Philip
Baldwin-Cleland, Rachel
Sahnan, Kapil
Hart, Ailsa
Limdi, Jimmy K.
Mclaughlin, John
Atkinson, David
Parker, Geoffrey J. M.
O’Connor, James P. B.
Little, Ross A.
Gowland, Penny A.
Moran, Gordon W.
author_sort Alyami, Ali
collection PubMed
description Perianal Crohn’s Disease (pCD) is a common manifestation of Crohn’s Disease. Absence of reliable disease measures makes disease monitoring unreliable. Qualitative MRI has been increasingly used for diagnosing and monitoring pCD and has shown potential for assessing response to treatment. Quantitative MRI sequences, such as diffusion-weighted imaging (DWI), dynamic contrast enhancement (DCE) and magnetisation transfer (MT), along with T2 relaxometry, offer opportunities to improve diagnostic capability. Quantitative MRI sequences (DWI, DCE, MT and T2) were used in a cohort of 25 pCD patients before and 12 weeks after biological therapy at two different field strengths (1.5 and 3 T). Disease activity was measured with the Perianal Crohn’s Disease Activity index (PDAI) and serum C-reactive protein (CRP). Diseased tissue areas on MRI were defined by a radiologist. A baseline model to predict outcome at 12 weeks was developed. No differences were seen in the quantitative MR measured in the diseased tissue regions from baseline to 12 weeks; however, PDAI and CRP decreased. Baseline PDAI, CRP, T2 relaxometry and surgical history were found to have a moderate ability to predict response after 12 weeks of biological treatment. Validation in larger cohorts with MRI and clinical measures are needed in order to further develop the model.
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spelling pubmed-86248772021-11-27 Quantitative Magnetic Resonance Imaging in Perianal Crohn’s Disease at 1.5 and 3.0 T: A Feasibility Study Alyami, Ali Hoad, Caroline L. Tench, Christopher Bannur, Uday Clarke, Christopher Latief, Khalid Argyriou, Konstantinos Lobo, Alan Lung, Philip Baldwin-Cleland, Rachel Sahnan, Kapil Hart, Ailsa Limdi, Jimmy K. Mclaughlin, John Atkinson, David Parker, Geoffrey J. M. O’Connor, James P. B. Little, Ross A. Gowland, Penny A. Moran, Gordon W. Diagnostics (Basel) Article Perianal Crohn’s Disease (pCD) is a common manifestation of Crohn’s Disease. Absence of reliable disease measures makes disease monitoring unreliable. Qualitative MRI has been increasingly used for diagnosing and monitoring pCD and has shown potential for assessing response to treatment. Quantitative MRI sequences, such as diffusion-weighted imaging (DWI), dynamic contrast enhancement (DCE) and magnetisation transfer (MT), along with T2 relaxometry, offer opportunities to improve diagnostic capability. Quantitative MRI sequences (DWI, DCE, MT and T2) were used in a cohort of 25 pCD patients before and 12 weeks after biological therapy at two different field strengths (1.5 and 3 T). Disease activity was measured with the Perianal Crohn’s Disease Activity index (PDAI) and serum C-reactive protein (CRP). Diseased tissue areas on MRI were defined by a radiologist. A baseline model to predict outcome at 12 weeks was developed. No differences were seen in the quantitative MR measured in the diseased tissue regions from baseline to 12 weeks; however, PDAI and CRP decreased. Baseline PDAI, CRP, T2 relaxometry and surgical history were found to have a moderate ability to predict response after 12 weeks of biological treatment. Validation in larger cohorts with MRI and clinical measures are needed in order to further develop the model. MDPI 2021-11-17 /pmc/articles/PMC8624877/ /pubmed/34829482 http://dx.doi.org/10.3390/diagnostics11112135 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Alyami, Ali
Hoad, Caroline L.
Tench, Christopher
Bannur, Uday
Clarke, Christopher
Latief, Khalid
Argyriou, Konstantinos
Lobo, Alan
Lung, Philip
Baldwin-Cleland, Rachel
Sahnan, Kapil
Hart, Ailsa
Limdi, Jimmy K.
Mclaughlin, John
Atkinson, David
Parker, Geoffrey J. M.
O’Connor, James P. B.
Little, Ross A.
Gowland, Penny A.
Moran, Gordon W.
Quantitative Magnetic Resonance Imaging in Perianal Crohn’s Disease at 1.5 and 3.0 T: A Feasibility Study
title Quantitative Magnetic Resonance Imaging in Perianal Crohn’s Disease at 1.5 and 3.0 T: A Feasibility Study
title_full Quantitative Magnetic Resonance Imaging in Perianal Crohn’s Disease at 1.5 and 3.0 T: A Feasibility Study
title_fullStr Quantitative Magnetic Resonance Imaging in Perianal Crohn’s Disease at 1.5 and 3.0 T: A Feasibility Study
title_full_unstemmed Quantitative Magnetic Resonance Imaging in Perianal Crohn’s Disease at 1.5 and 3.0 T: A Feasibility Study
title_short Quantitative Magnetic Resonance Imaging in Perianal Crohn’s Disease at 1.5 and 3.0 T: A Feasibility Study
title_sort quantitative magnetic resonance imaging in perianal crohn’s disease at 1.5 and 3.0 t: a feasibility study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624877/
https://www.ncbi.nlm.nih.gov/pubmed/34829482
http://dx.doi.org/10.3390/diagnostics11112135
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