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A New Design of Porosity Gradient Ti-6Al-4V Encapsulated Hydroxyapatite Dual Materials Composite Scaffold for Bone Defects

The tibia of New Zealand White rabbits was used as a model of critical bone defects to investigate a new design of composite scaffold for bone defects composed of dual materials. The all-in-one design of a titanium alloy (Ti-6Al-4V) scaffold comprised the structure of a bone plate and gradient poros...

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Autores principales: Pan, Cheng-Tang, Hsu, Wen-Hsin, Cheng, Yu-Shun, Wen, Zhi-Hong, Chen, Wen-Fan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624878/
https://www.ncbi.nlm.nih.gov/pubmed/34832706
http://dx.doi.org/10.3390/mi12111294
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author Pan, Cheng-Tang
Hsu, Wen-Hsin
Cheng, Yu-Shun
Wen, Zhi-Hong
Chen, Wen-Fan
author_facet Pan, Cheng-Tang
Hsu, Wen-Hsin
Cheng, Yu-Shun
Wen, Zhi-Hong
Chen, Wen-Fan
author_sort Pan, Cheng-Tang
collection PubMed
description The tibia of New Zealand White rabbits was used as a model of critical bone defects to investigate a new design of composite scaffold for bone defects composed of dual materials. The all-in-one design of a titanium alloy (Ti-6Al-4V) scaffold comprised the structure of a bone plate and gradient porosity cage. Hydroxyapatite (HAp), a biodegradable material, was encapsulated in the center of the scaffold. The gradient pore structure was designed with 70%-65%-60%-55%-50% porosity, since the stresses could be distributed more uniformly when the all-in-one scaffold was placed on the bone contact surface. By covering the center of the scaffold with a low strength of HAp to contact the relatively low strength of bone marrow tissues, the excessive stiffness of the Ti-6Al-4V can be effectively reduced and further diminish the incidence of the stress shielding effect. The simulation results show that the optimized composite scaffold for the 3D model of tibia had a maximum stress value of 27.862 MPa and a maximum strain of 0.065%. The scaffold prepared by selective laser melting was annealed and found that the Young’s coefficient increased from 126.44 GPa to 131.46 GPa, the hardness increased from 3.9 GPa to 4.12 GPa, and the strain decreased from 2.27% to 1.13%. The result demonstrates that the removal of residual stress can lead to a more stable structural strength, which can be used as a reference for the design of future clinical tibial defect repair scaffolds.
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spelling pubmed-86248782021-11-27 A New Design of Porosity Gradient Ti-6Al-4V Encapsulated Hydroxyapatite Dual Materials Composite Scaffold for Bone Defects Pan, Cheng-Tang Hsu, Wen-Hsin Cheng, Yu-Shun Wen, Zhi-Hong Chen, Wen-Fan Micromachines (Basel) Article The tibia of New Zealand White rabbits was used as a model of critical bone defects to investigate a new design of composite scaffold for bone defects composed of dual materials. The all-in-one design of a titanium alloy (Ti-6Al-4V) scaffold comprised the structure of a bone plate and gradient porosity cage. Hydroxyapatite (HAp), a biodegradable material, was encapsulated in the center of the scaffold. The gradient pore structure was designed with 70%-65%-60%-55%-50% porosity, since the stresses could be distributed more uniformly when the all-in-one scaffold was placed on the bone contact surface. By covering the center of the scaffold with a low strength of HAp to contact the relatively low strength of bone marrow tissues, the excessive stiffness of the Ti-6Al-4V can be effectively reduced and further diminish the incidence of the stress shielding effect. The simulation results show that the optimized composite scaffold for the 3D model of tibia had a maximum stress value of 27.862 MPa and a maximum strain of 0.065%. The scaffold prepared by selective laser melting was annealed and found that the Young’s coefficient increased from 126.44 GPa to 131.46 GPa, the hardness increased from 3.9 GPa to 4.12 GPa, and the strain decreased from 2.27% to 1.13%. The result demonstrates that the removal of residual stress can lead to a more stable structural strength, which can be used as a reference for the design of future clinical tibial defect repair scaffolds. MDPI 2021-10-21 /pmc/articles/PMC8624878/ /pubmed/34832706 http://dx.doi.org/10.3390/mi12111294 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pan, Cheng-Tang
Hsu, Wen-Hsin
Cheng, Yu-Shun
Wen, Zhi-Hong
Chen, Wen-Fan
A New Design of Porosity Gradient Ti-6Al-4V Encapsulated Hydroxyapatite Dual Materials Composite Scaffold for Bone Defects
title A New Design of Porosity Gradient Ti-6Al-4V Encapsulated Hydroxyapatite Dual Materials Composite Scaffold for Bone Defects
title_full A New Design of Porosity Gradient Ti-6Al-4V Encapsulated Hydroxyapatite Dual Materials Composite Scaffold for Bone Defects
title_fullStr A New Design of Porosity Gradient Ti-6Al-4V Encapsulated Hydroxyapatite Dual Materials Composite Scaffold for Bone Defects
title_full_unstemmed A New Design of Porosity Gradient Ti-6Al-4V Encapsulated Hydroxyapatite Dual Materials Composite Scaffold for Bone Defects
title_short A New Design of Porosity Gradient Ti-6Al-4V Encapsulated Hydroxyapatite Dual Materials Composite Scaffold for Bone Defects
title_sort new design of porosity gradient ti-6al-4v encapsulated hydroxyapatite dual materials composite scaffold for bone defects
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624878/
https://www.ncbi.nlm.nih.gov/pubmed/34832706
http://dx.doi.org/10.3390/mi12111294
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