Cargando…
A New Design of Porosity Gradient Ti-6Al-4V Encapsulated Hydroxyapatite Dual Materials Composite Scaffold for Bone Defects
The tibia of New Zealand White rabbits was used as a model of critical bone defects to investigate a new design of composite scaffold for bone defects composed of dual materials. The all-in-one design of a titanium alloy (Ti-6Al-4V) scaffold comprised the structure of a bone plate and gradient poros...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624878/ https://www.ncbi.nlm.nih.gov/pubmed/34832706 http://dx.doi.org/10.3390/mi12111294 |
_version_ | 1784606281397436416 |
---|---|
author | Pan, Cheng-Tang Hsu, Wen-Hsin Cheng, Yu-Shun Wen, Zhi-Hong Chen, Wen-Fan |
author_facet | Pan, Cheng-Tang Hsu, Wen-Hsin Cheng, Yu-Shun Wen, Zhi-Hong Chen, Wen-Fan |
author_sort | Pan, Cheng-Tang |
collection | PubMed |
description | The tibia of New Zealand White rabbits was used as a model of critical bone defects to investigate a new design of composite scaffold for bone defects composed of dual materials. The all-in-one design of a titanium alloy (Ti-6Al-4V) scaffold comprised the structure of a bone plate and gradient porosity cage. Hydroxyapatite (HAp), a biodegradable material, was encapsulated in the center of the scaffold. The gradient pore structure was designed with 70%-65%-60%-55%-50% porosity, since the stresses could be distributed more uniformly when the all-in-one scaffold was placed on the bone contact surface. By covering the center of the scaffold with a low strength of HAp to contact the relatively low strength of bone marrow tissues, the excessive stiffness of the Ti-6Al-4V can be effectively reduced and further diminish the incidence of the stress shielding effect. The simulation results show that the optimized composite scaffold for the 3D model of tibia had a maximum stress value of 27.862 MPa and a maximum strain of 0.065%. The scaffold prepared by selective laser melting was annealed and found that the Young’s coefficient increased from 126.44 GPa to 131.46 GPa, the hardness increased from 3.9 GPa to 4.12 GPa, and the strain decreased from 2.27% to 1.13%. The result demonstrates that the removal of residual stress can lead to a more stable structural strength, which can be used as a reference for the design of future clinical tibial defect repair scaffolds. |
format | Online Article Text |
id | pubmed-8624878 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86248782021-11-27 A New Design of Porosity Gradient Ti-6Al-4V Encapsulated Hydroxyapatite Dual Materials Composite Scaffold for Bone Defects Pan, Cheng-Tang Hsu, Wen-Hsin Cheng, Yu-Shun Wen, Zhi-Hong Chen, Wen-Fan Micromachines (Basel) Article The tibia of New Zealand White rabbits was used as a model of critical bone defects to investigate a new design of composite scaffold for bone defects composed of dual materials. The all-in-one design of a titanium alloy (Ti-6Al-4V) scaffold comprised the structure of a bone plate and gradient porosity cage. Hydroxyapatite (HAp), a biodegradable material, was encapsulated in the center of the scaffold. The gradient pore structure was designed with 70%-65%-60%-55%-50% porosity, since the stresses could be distributed more uniformly when the all-in-one scaffold was placed on the bone contact surface. By covering the center of the scaffold with a low strength of HAp to contact the relatively low strength of bone marrow tissues, the excessive stiffness of the Ti-6Al-4V can be effectively reduced and further diminish the incidence of the stress shielding effect. The simulation results show that the optimized composite scaffold for the 3D model of tibia had a maximum stress value of 27.862 MPa and a maximum strain of 0.065%. The scaffold prepared by selective laser melting was annealed and found that the Young’s coefficient increased from 126.44 GPa to 131.46 GPa, the hardness increased from 3.9 GPa to 4.12 GPa, and the strain decreased from 2.27% to 1.13%. The result demonstrates that the removal of residual stress can lead to a more stable structural strength, which can be used as a reference for the design of future clinical tibial defect repair scaffolds. MDPI 2021-10-21 /pmc/articles/PMC8624878/ /pubmed/34832706 http://dx.doi.org/10.3390/mi12111294 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Pan, Cheng-Tang Hsu, Wen-Hsin Cheng, Yu-Shun Wen, Zhi-Hong Chen, Wen-Fan A New Design of Porosity Gradient Ti-6Al-4V Encapsulated Hydroxyapatite Dual Materials Composite Scaffold for Bone Defects |
title | A New Design of Porosity Gradient Ti-6Al-4V Encapsulated Hydroxyapatite Dual Materials Composite Scaffold for Bone Defects |
title_full | A New Design of Porosity Gradient Ti-6Al-4V Encapsulated Hydroxyapatite Dual Materials Composite Scaffold for Bone Defects |
title_fullStr | A New Design of Porosity Gradient Ti-6Al-4V Encapsulated Hydroxyapatite Dual Materials Composite Scaffold for Bone Defects |
title_full_unstemmed | A New Design of Porosity Gradient Ti-6Al-4V Encapsulated Hydroxyapatite Dual Materials Composite Scaffold for Bone Defects |
title_short | A New Design of Porosity Gradient Ti-6Al-4V Encapsulated Hydroxyapatite Dual Materials Composite Scaffold for Bone Defects |
title_sort | new design of porosity gradient ti-6al-4v encapsulated hydroxyapatite dual materials composite scaffold for bone defects |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624878/ https://www.ncbi.nlm.nih.gov/pubmed/34832706 http://dx.doi.org/10.3390/mi12111294 |
work_keys_str_mv | AT panchengtang anewdesignofporositygradientti6al4vencapsulatedhydroxyapatitedualmaterialscompositescaffoldforbonedefects AT hsuwenhsin anewdesignofporositygradientti6al4vencapsulatedhydroxyapatitedualmaterialscompositescaffoldforbonedefects AT chengyushun anewdesignofporositygradientti6al4vencapsulatedhydroxyapatitedualmaterialscompositescaffoldforbonedefects AT wenzhihong anewdesignofporositygradientti6al4vencapsulatedhydroxyapatitedualmaterialscompositescaffoldforbonedefects AT chenwenfan anewdesignofporositygradientti6al4vencapsulatedhydroxyapatitedualmaterialscompositescaffoldforbonedefects AT panchengtang newdesignofporositygradientti6al4vencapsulatedhydroxyapatitedualmaterialscompositescaffoldforbonedefects AT hsuwenhsin newdesignofporositygradientti6al4vencapsulatedhydroxyapatitedualmaterialscompositescaffoldforbonedefects AT chengyushun newdesignofporositygradientti6al4vencapsulatedhydroxyapatitedualmaterialscompositescaffoldforbonedefects AT wenzhihong newdesignofporositygradientti6al4vencapsulatedhydroxyapatitedualmaterialscompositescaffoldforbonedefects AT chenwenfan newdesignofporositygradientti6al4vencapsulatedhydroxyapatitedualmaterialscompositescaffoldforbonedefects |