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Biomarkers in Ovarian Pathology: From Screening to Diagnosis. Review of the Literature

Background: Ovarian cancer has a low incidence, but high mortality due to a habitual diagnosis in advanced cancer stages. Currently, used biomarkers have good sensitivity, but low specificity. Aim: To determine the usefulness of the biomarkers and algorithms used up to now in the screening, diagnosi...

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Autores principales: Elorriaga, Miguel Ángel, Neyro, José Luis, Mieza, Jon, Cristóbal, Ignacio, Llueca, Antoni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624892/
https://www.ncbi.nlm.nih.gov/pubmed/34834467
http://dx.doi.org/10.3390/jpm11111115
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author Elorriaga, Miguel Ángel
Neyro, José Luis
Mieza, Jon
Cristóbal, Ignacio
Llueca, Antoni
author_facet Elorriaga, Miguel Ángel
Neyro, José Luis
Mieza, Jon
Cristóbal, Ignacio
Llueca, Antoni
author_sort Elorriaga, Miguel Ángel
collection PubMed
description Background: Ovarian cancer has a low incidence, but high mortality due to a habitual diagnosis in advanced cancer stages. Currently, used biomarkers have good sensitivity, but low specificity. Aim: To determine the usefulness of the biomarkers and algorithms used up to now in the screening, diagnosis, response to treatments and identification of recurrence in patients with ovarian masses. Methodology: Systematic search of publications in English in the Medline-PubMed database with the terms: “biomarkers”, “tumour”, “tumour biomarkers”, “marker”, “tumour marker”, “ovarian cancer”, “ovarian”, “Neoplasms”, “cancer”, CA-125 Antigen; Human Epididymis-specific Protein E4; Risk of Malignancy Index (RMI); Risk of Ovarian Malignancy Algorithm (ROMA); Ovarian Neoplasms. Original articles, clinical trials, reviews, systematic reviews and meta-analyses, published between January 2000 and November 2020, were selected to determine the usefulness (among others) of CA 125 and HE4 antigen in ovarian cancer. Results: Finally, 39 transcendental publications were selected to write this article to determine the usefulness of tumour markers and algorithms in ovarian cancer. Conclusions: The usefulness of the tumour markers antigen CA125 and antigen HE4 individually or as a basis for decision-making algorithms has low specificity; however, there is little evidence that confirms their usefulness as markers in ovarian cancer screening.
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spelling pubmed-86248922021-11-27 Biomarkers in Ovarian Pathology: From Screening to Diagnosis. Review of the Literature Elorriaga, Miguel Ángel Neyro, José Luis Mieza, Jon Cristóbal, Ignacio Llueca, Antoni J Pers Med Review Background: Ovarian cancer has a low incidence, but high mortality due to a habitual diagnosis in advanced cancer stages. Currently, used biomarkers have good sensitivity, but low specificity. Aim: To determine the usefulness of the biomarkers and algorithms used up to now in the screening, diagnosis, response to treatments and identification of recurrence in patients with ovarian masses. Methodology: Systematic search of publications in English in the Medline-PubMed database with the terms: “biomarkers”, “tumour”, “tumour biomarkers”, “marker”, “tumour marker”, “ovarian cancer”, “ovarian”, “Neoplasms”, “cancer”, CA-125 Antigen; Human Epididymis-specific Protein E4; Risk of Malignancy Index (RMI); Risk of Ovarian Malignancy Algorithm (ROMA); Ovarian Neoplasms. Original articles, clinical trials, reviews, systematic reviews and meta-analyses, published between January 2000 and November 2020, were selected to determine the usefulness (among others) of CA 125 and HE4 antigen in ovarian cancer. Results: Finally, 39 transcendental publications were selected to write this article to determine the usefulness of tumour markers and algorithms in ovarian cancer. Conclusions: The usefulness of the tumour markers antigen CA125 and antigen HE4 individually or as a basis for decision-making algorithms has low specificity; however, there is little evidence that confirms their usefulness as markers in ovarian cancer screening. MDPI 2021-10-29 /pmc/articles/PMC8624892/ /pubmed/34834467 http://dx.doi.org/10.3390/jpm11111115 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Elorriaga, Miguel Ángel
Neyro, José Luis
Mieza, Jon
Cristóbal, Ignacio
Llueca, Antoni
Biomarkers in Ovarian Pathology: From Screening to Diagnosis. Review of the Literature
title Biomarkers in Ovarian Pathology: From Screening to Diagnosis. Review of the Literature
title_full Biomarkers in Ovarian Pathology: From Screening to Diagnosis. Review of the Literature
title_fullStr Biomarkers in Ovarian Pathology: From Screening to Diagnosis. Review of the Literature
title_full_unstemmed Biomarkers in Ovarian Pathology: From Screening to Diagnosis. Review of the Literature
title_short Biomarkers in Ovarian Pathology: From Screening to Diagnosis. Review of the Literature
title_sort biomarkers in ovarian pathology: from screening to diagnosis. review of the literature
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624892/
https://www.ncbi.nlm.nih.gov/pubmed/34834467
http://dx.doi.org/10.3390/jpm11111115
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