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GLUT1, GLUT3 Expression and 18FDG-PET/CT in Human Malignant Melanoma: What Relationship Exists? New Insights and Perspectives

Background: Malignant melanoma is the most aggressive of skin cancers and the 19th most common cancer worldwide, with an estimated age-standardized incidence rate of 2.8–3.1 per 100,000; although there have been clear advances in therapeutic treatment, the prognosis of MM patients with Breslow thick...

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Autores principales: Cazzato, Gerardo, Colagrande, Anna, Cimmino, Antonietta, Abbatepaolo, Caterina, Bellitti, Emilio, Romita, Paolo, Lospalluti, Lucia, Foti, Caterina, Arezzo, Francesca, Loizzi, Vera, Lettini, Teresa, Sablone, Sara, Resta, Leonardo, Cormio, Gennaro, Ingravallo, Giuseppe, Rossi, Roberta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624914/
https://www.ncbi.nlm.nih.gov/pubmed/34831313
http://dx.doi.org/10.3390/cells10113090
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author Cazzato, Gerardo
Colagrande, Anna
Cimmino, Antonietta
Abbatepaolo, Caterina
Bellitti, Emilio
Romita, Paolo
Lospalluti, Lucia
Foti, Caterina
Arezzo, Francesca
Loizzi, Vera
Lettini, Teresa
Sablone, Sara
Resta, Leonardo
Cormio, Gennaro
Ingravallo, Giuseppe
Rossi, Roberta
author_facet Cazzato, Gerardo
Colagrande, Anna
Cimmino, Antonietta
Abbatepaolo, Caterina
Bellitti, Emilio
Romita, Paolo
Lospalluti, Lucia
Foti, Caterina
Arezzo, Francesca
Loizzi, Vera
Lettini, Teresa
Sablone, Sara
Resta, Leonardo
Cormio, Gennaro
Ingravallo, Giuseppe
Rossi, Roberta
author_sort Cazzato, Gerardo
collection PubMed
description Background: Malignant melanoma is the most aggressive of skin cancers and the 19th most common cancer worldwide, with an estimated age-standardized incidence rate of 2.8–3.1 per 100,000; although there have been clear advances in therapeutic treatment, the prognosis of MM patients with Breslow thickness greater than 1 mm is still quite poor today. The study of how melanoma cells manage to survive and proliferate by consuming glucose has been partially addressed in the literature, but some rather interesting results are starting to be present. Methods: A systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and a search of PubMed and Web of Sciences (WoS) databases was performed until 27 September 2021 using the terms: glucose transporter 1 and 3 and GLUT1/3 in combination with each of the following: melanoma, neoplasm and immunohistochemistry. Results: In total, 46 records were initially identified in the literature search, of which six were duplicates. After screening for eligibility and inclusion criteria, 16 publications were ultimately included. Conclusions: the results discussed regarding the role and expression of GLUT are still far from definitive, but further steps toward understanding and stopping this mechanism have, at least in part, been taken. New studies and new discoveries should lead to further clarification of some aspects since the various mechanisms of glucose uptake by neoplastic cells are not limited to the transporters of the GLUT family alone.
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spelling pubmed-86249142021-11-27 GLUT1, GLUT3 Expression and 18FDG-PET/CT in Human Malignant Melanoma: What Relationship Exists? New Insights and Perspectives Cazzato, Gerardo Colagrande, Anna Cimmino, Antonietta Abbatepaolo, Caterina Bellitti, Emilio Romita, Paolo Lospalluti, Lucia Foti, Caterina Arezzo, Francesca Loizzi, Vera Lettini, Teresa Sablone, Sara Resta, Leonardo Cormio, Gennaro Ingravallo, Giuseppe Rossi, Roberta Cells Review Background: Malignant melanoma is the most aggressive of skin cancers and the 19th most common cancer worldwide, with an estimated age-standardized incidence rate of 2.8–3.1 per 100,000; although there have been clear advances in therapeutic treatment, the prognosis of MM patients with Breslow thickness greater than 1 mm is still quite poor today. The study of how melanoma cells manage to survive and proliferate by consuming glucose has been partially addressed in the literature, but some rather interesting results are starting to be present. Methods: A systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and a search of PubMed and Web of Sciences (WoS) databases was performed until 27 September 2021 using the terms: glucose transporter 1 and 3 and GLUT1/3 in combination with each of the following: melanoma, neoplasm and immunohistochemistry. Results: In total, 46 records were initially identified in the literature search, of which six were duplicates. After screening for eligibility and inclusion criteria, 16 publications were ultimately included. Conclusions: the results discussed regarding the role and expression of GLUT are still far from definitive, but further steps toward understanding and stopping this mechanism have, at least in part, been taken. New studies and new discoveries should lead to further clarification of some aspects since the various mechanisms of glucose uptake by neoplastic cells are not limited to the transporters of the GLUT family alone. MDPI 2021-11-09 /pmc/articles/PMC8624914/ /pubmed/34831313 http://dx.doi.org/10.3390/cells10113090 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Cazzato, Gerardo
Colagrande, Anna
Cimmino, Antonietta
Abbatepaolo, Caterina
Bellitti, Emilio
Romita, Paolo
Lospalluti, Lucia
Foti, Caterina
Arezzo, Francesca
Loizzi, Vera
Lettini, Teresa
Sablone, Sara
Resta, Leonardo
Cormio, Gennaro
Ingravallo, Giuseppe
Rossi, Roberta
GLUT1, GLUT3 Expression and 18FDG-PET/CT in Human Malignant Melanoma: What Relationship Exists? New Insights and Perspectives
title GLUT1, GLUT3 Expression and 18FDG-PET/CT in Human Malignant Melanoma: What Relationship Exists? New Insights and Perspectives
title_full GLUT1, GLUT3 Expression and 18FDG-PET/CT in Human Malignant Melanoma: What Relationship Exists? New Insights and Perspectives
title_fullStr GLUT1, GLUT3 Expression and 18FDG-PET/CT in Human Malignant Melanoma: What Relationship Exists? New Insights and Perspectives
title_full_unstemmed GLUT1, GLUT3 Expression and 18FDG-PET/CT in Human Malignant Melanoma: What Relationship Exists? New Insights and Perspectives
title_short GLUT1, GLUT3 Expression and 18FDG-PET/CT in Human Malignant Melanoma: What Relationship Exists? New Insights and Perspectives
title_sort glut1, glut3 expression and 18fdg-pet/ct in human malignant melanoma: what relationship exists? new insights and perspectives
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624914/
https://www.ncbi.nlm.nih.gov/pubmed/34831313
http://dx.doi.org/10.3390/cells10113090
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