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GLUT1, GLUT3 Expression and 18FDG-PET/CT in Human Malignant Melanoma: What Relationship Exists? New Insights and Perspectives
Background: Malignant melanoma is the most aggressive of skin cancers and the 19th most common cancer worldwide, with an estimated age-standardized incidence rate of 2.8–3.1 per 100,000; although there have been clear advances in therapeutic treatment, the prognosis of MM patients with Breslow thick...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624914/ https://www.ncbi.nlm.nih.gov/pubmed/34831313 http://dx.doi.org/10.3390/cells10113090 |
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author | Cazzato, Gerardo Colagrande, Anna Cimmino, Antonietta Abbatepaolo, Caterina Bellitti, Emilio Romita, Paolo Lospalluti, Lucia Foti, Caterina Arezzo, Francesca Loizzi, Vera Lettini, Teresa Sablone, Sara Resta, Leonardo Cormio, Gennaro Ingravallo, Giuseppe Rossi, Roberta |
author_facet | Cazzato, Gerardo Colagrande, Anna Cimmino, Antonietta Abbatepaolo, Caterina Bellitti, Emilio Romita, Paolo Lospalluti, Lucia Foti, Caterina Arezzo, Francesca Loizzi, Vera Lettini, Teresa Sablone, Sara Resta, Leonardo Cormio, Gennaro Ingravallo, Giuseppe Rossi, Roberta |
author_sort | Cazzato, Gerardo |
collection | PubMed |
description | Background: Malignant melanoma is the most aggressive of skin cancers and the 19th most common cancer worldwide, with an estimated age-standardized incidence rate of 2.8–3.1 per 100,000; although there have been clear advances in therapeutic treatment, the prognosis of MM patients with Breslow thickness greater than 1 mm is still quite poor today. The study of how melanoma cells manage to survive and proliferate by consuming glucose has been partially addressed in the literature, but some rather interesting results are starting to be present. Methods: A systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and a search of PubMed and Web of Sciences (WoS) databases was performed until 27 September 2021 using the terms: glucose transporter 1 and 3 and GLUT1/3 in combination with each of the following: melanoma, neoplasm and immunohistochemistry. Results: In total, 46 records were initially identified in the literature search, of which six were duplicates. After screening for eligibility and inclusion criteria, 16 publications were ultimately included. Conclusions: the results discussed regarding the role and expression of GLUT are still far from definitive, but further steps toward understanding and stopping this mechanism have, at least in part, been taken. New studies and new discoveries should lead to further clarification of some aspects since the various mechanisms of glucose uptake by neoplastic cells are not limited to the transporters of the GLUT family alone. |
format | Online Article Text |
id | pubmed-8624914 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86249142021-11-27 GLUT1, GLUT3 Expression and 18FDG-PET/CT in Human Malignant Melanoma: What Relationship Exists? New Insights and Perspectives Cazzato, Gerardo Colagrande, Anna Cimmino, Antonietta Abbatepaolo, Caterina Bellitti, Emilio Romita, Paolo Lospalluti, Lucia Foti, Caterina Arezzo, Francesca Loizzi, Vera Lettini, Teresa Sablone, Sara Resta, Leonardo Cormio, Gennaro Ingravallo, Giuseppe Rossi, Roberta Cells Review Background: Malignant melanoma is the most aggressive of skin cancers and the 19th most common cancer worldwide, with an estimated age-standardized incidence rate of 2.8–3.1 per 100,000; although there have been clear advances in therapeutic treatment, the prognosis of MM patients with Breslow thickness greater than 1 mm is still quite poor today. The study of how melanoma cells manage to survive and proliferate by consuming glucose has been partially addressed in the literature, but some rather interesting results are starting to be present. Methods: A systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and a search of PubMed and Web of Sciences (WoS) databases was performed until 27 September 2021 using the terms: glucose transporter 1 and 3 and GLUT1/3 in combination with each of the following: melanoma, neoplasm and immunohistochemistry. Results: In total, 46 records were initially identified in the literature search, of which six were duplicates. After screening for eligibility and inclusion criteria, 16 publications were ultimately included. Conclusions: the results discussed regarding the role and expression of GLUT are still far from definitive, but further steps toward understanding and stopping this mechanism have, at least in part, been taken. New studies and new discoveries should lead to further clarification of some aspects since the various mechanisms of glucose uptake by neoplastic cells are not limited to the transporters of the GLUT family alone. MDPI 2021-11-09 /pmc/articles/PMC8624914/ /pubmed/34831313 http://dx.doi.org/10.3390/cells10113090 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Cazzato, Gerardo Colagrande, Anna Cimmino, Antonietta Abbatepaolo, Caterina Bellitti, Emilio Romita, Paolo Lospalluti, Lucia Foti, Caterina Arezzo, Francesca Loizzi, Vera Lettini, Teresa Sablone, Sara Resta, Leonardo Cormio, Gennaro Ingravallo, Giuseppe Rossi, Roberta GLUT1, GLUT3 Expression and 18FDG-PET/CT in Human Malignant Melanoma: What Relationship Exists? New Insights and Perspectives |
title | GLUT1, GLUT3 Expression and 18FDG-PET/CT in Human Malignant Melanoma: What Relationship Exists? New Insights and Perspectives |
title_full | GLUT1, GLUT3 Expression and 18FDG-PET/CT in Human Malignant Melanoma: What Relationship Exists? New Insights and Perspectives |
title_fullStr | GLUT1, GLUT3 Expression and 18FDG-PET/CT in Human Malignant Melanoma: What Relationship Exists? New Insights and Perspectives |
title_full_unstemmed | GLUT1, GLUT3 Expression and 18FDG-PET/CT in Human Malignant Melanoma: What Relationship Exists? New Insights and Perspectives |
title_short | GLUT1, GLUT3 Expression and 18FDG-PET/CT in Human Malignant Melanoma: What Relationship Exists? New Insights and Perspectives |
title_sort | glut1, glut3 expression and 18fdg-pet/ct in human malignant melanoma: what relationship exists? new insights and perspectives |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624914/ https://www.ncbi.nlm.nih.gov/pubmed/34831313 http://dx.doi.org/10.3390/cells10113090 |
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