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Clinical Significance and Prognostic Value of Hemostasis Parameters in 337 Patients with Acute Infective Endocarditis

(1) Background: The aim of this study was to assess the clinical significance and prognostic role of the main hemostasis parameters in infective endocarditis (IE): prothrombin time as international normalized ratio (PT-INR), activated partial thromboplastin time (aPTT), fibrinogen, D-dimers, platele...

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Autores principales: Zampino, Rosa, Iossa, Domenico, Ursi, Maria Paola, Bertolino, Lorenzo, Karruli, Arta, Molaro, Rosa, Esposito, Gennaro, Vitrone, Martina, D’Amico, Fabiana, Albisinni, Rosina, Durante-Mangoni, Emanuele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624946/
https://www.ncbi.nlm.nih.gov/pubmed/34830670
http://dx.doi.org/10.3390/jcm10225386
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author Zampino, Rosa
Iossa, Domenico
Ursi, Maria Paola
Bertolino, Lorenzo
Karruli, Arta
Molaro, Rosa
Esposito, Gennaro
Vitrone, Martina
D’Amico, Fabiana
Albisinni, Rosina
Durante-Mangoni, Emanuele
author_facet Zampino, Rosa
Iossa, Domenico
Ursi, Maria Paola
Bertolino, Lorenzo
Karruli, Arta
Molaro, Rosa
Esposito, Gennaro
Vitrone, Martina
D’Amico, Fabiana
Albisinni, Rosina
Durante-Mangoni, Emanuele
author_sort Zampino, Rosa
collection PubMed
description (1) Background: The aim of this study was to assess the clinical significance and prognostic role of the main hemostasis parameters in infective endocarditis (IE): prothrombin time as international normalized ratio (PT-INR), activated partial thromboplastin time (aPTT), fibrinogen, D-dimers, platelet count, homocysteine. (2) Methods: We studied 337 patients with IE. Clinical, hemato-chemical and echocardiography parameters were analyzed. Coagulation parameters were measured on admission. (3) Results: D-dimers levels (p = 0.012) and a prolonged PT-INR (p = 0.013) were associated with higher in-hospital mortality, while prolonged aPTT (p = 0.021) was associated with increased 1-year mortality. Staphylococcus aureus (S. aureus) infection (p = 0.003), prosthetic valve endocarditis (PVE) (p = 0.001), surgical indication (p = 0.002) and higher D-dimer levels (p = 0.005) were independent predictors of in-hospital mortality. PVE (p = 0.001), a higher Charlson Comorbidity Index (p = 0.049), surgical indication (p = 0.001) and prolonged aPTT (p = 0.012) were independent predictors of 1-year mortality. Higher levels of D-dimers (p < 0.001) and a shorter aPTT (p < 0.001) were associated with embolic complications of IE. S. aureus etiology was bound to higher D-dimers levels (p < 0.001) and a shorter aPTT (p = 0.006). (4) Conclusions: Elevated D-dimers are associated with a higher risk for in-hospital mortality in IE patients. High D-dimers and a short aPTT are associated with a higher risk for embolic events in IE. A longer aPTT is associated with 1-year mortality.
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spelling pubmed-86249462021-11-27 Clinical Significance and Prognostic Value of Hemostasis Parameters in 337 Patients with Acute Infective Endocarditis Zampino, Rosa Iossa, Domenico Ursi, Maria Paola Bertolino, Lorenzo Karruli, Arta Molaro, Rosa Esposito, Gennaro Vitrone, Martina D’Amico, Fabiana Albisinni, Rosina Durante-Mangoni, Emanuele J Clin Med Article (1) Background: The aim of this study was to assess the clinical significance and prognostic role of the main hemostasis parameters in infective endocarditis (IE): prothrombin time as international normalized ratio (PT-INR), activated partial thromboplastin time (aPTT), fibrinogen, D-dimers, platelet count, homocysteine. (2) Methods: We studied 337 patients with IE. Clinical, hemato-chemical and echocardiography parameters were analyzed. Coagulation parameters were measured on admission. (3) Results: D-dimers levels (p = 0.012) and a prolonged PT-INR (p = 0.013) were associated with higher in-hospital mortality, while prolonged aPTT (p = 0.021) was associated with increased 1-year mortality. Staphylococcus aureus (S. aureus) infection (p = 0.003), prosthetic valve endocarditis (PVE) (p = 0.001), surgical indication (p = 0.002) and higher D-dimer levels (p = 0.005) were independent predictors of in-hospital mortality. PVE (p = 0.001), a higher Charlson Comorbidity Index (p = 0.049), surgical indication (p = 0.001) and prolonged aPTT (p = 0.012) were independent predictors of 1-year mortality. Higher levels of D-dimers (p < 0.001) and a shorter aPTT (p < 0.001) were associated with embolic complications of IE. S. aureus etiology was bound to higher D-dimers levels (p < 0.001) and a shorter aPTT (p = 0.006). (4) Conclusions: Elevated D-dimers are associated with a higher risk for in-hospital mortality in IE patients. High D-dimers and a short aPTT are associated with a higher risk for embolic events in IE. A longer aPTT is associated with 1-year mortality. MDPI 2021-11-18 /pmc/articles/PMC8624946/ /pubmed/34830670 http://dx.doi.org/10.3390/jcm10225386 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zampino, Rosa
Iossa, Domenico
Ursi, Maria Paola
Bertolino, Lorenzo
Karruli, Arta
Molaro, Rosa
Esposito, Gennaro
Vitrone, Martina
D’Amico, Fabiana
Albisinni, Rosina
Durante-Mangoni, Emanuele
Clinical Significance and Prognostic Value of Hemostasis Parameters in 337 Patients with Acute Infective Endocarditis
title Clinical Significance and Prognostic Value of Hemostasis Parameters in 337 Patients with Acute Infective Endocarditis
title_full Clinical Significance and Prognostic Value of Hemostasis Parameters in 337 Patients with Acute Infective Endocarditis
title_fullStr Clinical Significance and Prognostic Value of Hemostasis Parameters in 337 Patients with Acute Infective Endocarditis
title_full_unstemmed Clinical Significance and Prognostic Value of Hemostasis Parameters in 337 Patients with Acute Infective Endocarditis
title_short Clinical Significance and Prognostic Value of Hemostasis Parameters in 337 Patients with Acute Infective Endocarditis
title_sort clinical significance and prognostic value of hemostasis parameters in 337 patients with acute infective endocarditis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624946/
https://www.ncbi.nlm.nih.gov/pubmed/34830670
http://dx.doi.org/10.3390/jcm10225386
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