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Skeletal Deficits in Male and Female down Syndrome Model Mice Arise Independent of Normalized Dyrk1a Expression in Osteoblasts

Trisomy 21 (Ts21) causes alterations in skeletal development resulting in decreased bone mass, shortened stature and weaker bones in individuals with Down syndrome (DS). There is a sexual dimorphism in bone mineral density (BMD) deficits associated with DS with males displaying earlier deficits than...

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Detalles Bibliográficos
Autores principales:	Thomas, Jared R., Sloan, Kourtney, Cave, Kelsey, Wallace, Joseph M., Roper, Randall J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624983/ https://www.ncbi.nlm.nih.gov/pubmed/34828335 http://dx.doi.org/10.3390/genes12111729

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