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Vaccinated Patients Admitted in ICU with Severe Pneumonia Due to SARS-CoV-2: A Multicenter Pilot Study

Background: The aim of this study was to analyze the percentage of patients admitted to the ICU having received the vaccine against COVID-19, to describe the clinical profile of vaccinated patients admitted to the ICU, and to assess the humoral immune response to vaccination. Methods: In this multic...

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Autores principales: Estella, Ángel, Cantón, Mª Luisa, Muñoz, Laura, Higueras, Isabel Rodriguez, Recuerda Núñez, María, Tejero Aranguren, Julia, Zaya, Benito, Gómez, Carmen, Amaya, Rosario, Hurtado Martinez, Ángela, del Valle Odero Bernal, María, De la Fuente, Carmen, Alados, Juan Carlos, Garnacho-Montero, Jose
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8625038/
https://www.ncbi.nlm.nih.gov/pubmed/34834437
http://dx.doi.org/10.3390/jpm11111086
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author Estella, Ángel
Cantón, Mª Luisa
Muñoz, Laura
Higueras, Isabel Rodriguez
Recuerda Núñez, María
Tejero Aranguren, Julia
Zaya, Benito
Gómez, Carmen
Amaya, Rosario
Hurtado Martinez, Ángela
del Valle Odero Bernal, María
De la Fuente, Carmen
Alados, Juan Carlos
Garnacho-Montero, Jose
author_facet Estella, Ángel
Cantón, Mª Luisa
Muñoz, Laura
Higueras, Isabel Rodriguez
Recuerda Núñez, María
Tejero Aranguren, Julia
Zaya, Benito
Gómez, Carmen
Amaya, Rosario
Hurtado Martinez, Ángela
del Valle Odero Bernal, María
De la Fuente, Carmen
Alados, Juan Carlos
Garnacho-Montero, Jose
author_sort Estella, Ángel
collection PubMed
description Background: The aim of this study was to analyze the percentage of patients admitted to the ICU having received the vaccine against COVID-19, to describe the clinical profile of vaccinated patients admitted to the ICU, and to assess the humoral immune response to vaccination. Methods: In this multicenter prospective descriptive cohort study, consecutive critically ill patients with confirmed SARS-CoV-2 pneumonia who received at least one dose of the SARS-CoV-2 vaccine were included. The time of study was from 1 July to 10 August of 2021. Results: Of the 94 consecutive patients from seven Andalusian ICUs admitted during the time of study, 50 (53.2%) received at least one dose of anti SARS-CoV-2 vaccine. No patient was admitted having previously had SARS-CoV-2 infection. The B.1.617.2 (Delta) variant was the most frequently identified, in 80.76% of cases. Patients with a complete vaccination with non-optimal antibody levels were immunocompromised. Fifteen patients were admitted to the ICU with Acute Respiratory Distress Syndrome (ARDS) without having completed their vaccination; the clinical profile was younger and with less comorbidities compared to patients with full vaccination. There were no differences in severity of ARDS. Conclusions: Most of the patients who were admitted to the ICU having received a dose of the vaccine were not optimally vaccinated; fully vaccinated patients who did not obtain optimal serum antibody levels were patients considered immunocompromised.
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spelling pubmed-86250382021-11-27 Vaccinated Patients Admitted in ICU with Severe Pneumonia Due to SARS-CoV-2: A Multicenter Pilot Study Estella, Ángel Cantón, Mª Luisa Muñoz, Laura Higueras, Isabel Rodriguez Recuerda Núñez, María Tejero Aranguren, Julia Zaya, Benito Gómez, Carmen Amaya, Rosario Hurtado Martinez, Ángela del Valle Odero Bernal, María De la Fuente, Carmen Alados, Juan Carlos Garnacho-Montero, Jose J Pers Med Article Background: The aim of this study was to analyze the percentage of patients admitted to the ICU having received the vaccine against COVID-19, to describe the clinical profile of vaccinated patients admitted to the ICU, and to assess the humoral immune response to vaccination. Methods: In this multicenter prospective descriptive cohort study, consecutive critically ill patients with confirmed SARS-CoV-2 pneumonia who received at least one dose of the SARS-CoV-2 vaccine were included. The time of study was from 1 July to 10 August of 2021. Results: Of the 94 consecutive patients from seven Andalusian ICUs admitted during the time of study, 50 (53.2%) received at least one dose of anti SARS-CoV-2 vaccine. No patient was admitted having previously had SARS-CoV-2 infection. The B.1.617.2 (Delta) variant was the most frequently identified, in 80.76% of cases. Patients with a complete vaccination with non-optimal antibody levels were immunocompromised. Fifteen patients were admitted to the ICU with Acute Respiratory Distress Syndrome (ARDS) without having completed their vaccination; the clinical profile was younger and with less comorbidities compared to patients with full vaccination. There were no differences in severity of ARDS. Conclusions: Most of the patients who were admitted to the ICU having received a dose of the vaccine were not optimally vaccinated; fully vaccinated patients who did not obtain optimal serum antibody levels were patients considered immunocompromised. MDPI 2021-10-25 /pmc/articles/PMC8625038/ /pubmed/34834437 http://dx.doi.org/10.3390/jpm11111086 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Estella, Ángel
Cantón, Mª Luisa
Muñoz, Laura
Higueras, Isabel Rodriguez
Recuerda Núñez, María
Tejero Aranguren, Julia
Zaya, Benito
Gómez, Carmen
Amaya, Rosario
Hurtado Martinez, Ángela
del Valle Odero Bernal, María
De la Fuente, Carmen
Alados, Juan Carlos
Garnacho-Montero, Jose
Vaccinated Patients Admitted in ICU with Severe Pneumonia Due to SARS-CoV-2: A Multicenter Pilot Study
title Vaccinated Patients Admitted in ICU with Severe Pneumonia Due to SARS-CoV-2: A Multicenter Pilot Study
title_full Vaccinated Patients Admitted in ICU with Severe Pneumonia Due to SARS-CoV-2: A Multicenter Pilot Study
title_fullStr Vaccinated Patients Admitted in ICU with Severe Pneumonia Due to SARS-CoV-2: A Multicenter Pilot Study
title_full_unstemmed Vaccinated Patients Admitted in ICU with Severe Pneumonia Due to SARS-CoV-2: A Multicenter Pilot Study
title_short Vaccinated Patients Admitted in ICU with Severe Pneumonia Due to SARS-CoV-2: A Multicenter Pilot Study
title_sort vaccinated patients admitted in icu with severe pneumonia due to sars-cov-2: a multicenter pilot study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8625038/
https://www.ncbi.nlm.nih.gov/pubmed/34834437
http://dx.doi.org/10.3390/jpm11111086
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