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Serum Neutrophil Gelatinase-Associated Lipocalin (NGAL) Could Provide Better Accuracy Than Creatinine in Predicting Acute Kidney Injury Development in Critically Ill Patients

Acute kidney injury (AKI) is one of the most common complications in critically ill patients. In recent years, studies have focused on exploring new biomarkers for the early diagnosis and prognosis of AKI. The aim of this study was to investigate serum prognostic biomarkers (neutrophil gelatinase-as...

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Autores principales: Jahaj, Edison, Vassiliou, Alice G., Pratikaki, Maria, Gallos, Parisis, Mastora, Zafeiria, Dimopoulou, Ioanna, Orfanos, Stylianos E., Orfanos, Philippos, Lagiou, Pagona, Kotanidou, Anastasia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8625137/
https://www.ncbi.nlm.nih.gov/pubmed/34830657
http://dx.doi.org/10.3390/jcm10225379
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author Jahaj, Edison
Vassiliou, Alice G.
Pratikaki, Maria
Gallos, Parisis
Mastora, Zafeiria
Dimopoulou, Ioanna
Orfanos, Stylianos E.
Orfanos, Philippos
Lagiou, Pagona
Kotanidou, Anastasia
author_facet Jahaj, Edison
Vassiliou, Alice G.
Pratikaki, Maria
Gallos, Parisis
Mastora, Zafeiria
Dimopoulou, Ioanna
Orfanos, Stylianos E.
Orfanos, Philippos
Lagiou, Pagona
Kotanidou, Anastasia
author_sort Jahaj, Edison
collection PubMed
description Acute kidney injury (AKI) is one of the most common complications in critically ill patients. In recent years, studies have focused on exploring new biomarkers for the early diagnosis and prognosis of AKI. The aim of this study was to investigate serum prognostic biomarkers (neutrophil gelatinase-associated lipocalin, NGAL, and creatinine) of AKI in critically ill patients. The study included 266 critically ill, initially nonseptic, patients admitted to a multidisciplinary ICU. Serum levels of NGAL and creatinine were measured at ICU admission. ROC curves were generated to estimate the prognostic value of the biomarkers, while a logistic regression analysis was performed to assess their association with an increased AKI risk. Patients were divided in two groups based on the development (n = 98) or not (n = 168) of AKI during their ICU stay. Serum NGAL levels at ICU admission were significantly higher in those who subsequently developed AKI compared to those who did not (p < 0.0001). NGAL was shown to be more accurate in predicting AKI development than creatinine; furthermore, NGAL levels were associated with an increased risk of AKI development (1.005 (1.002–1.008), p < 0.0001). In the present study, we were able to demonstrate that increased serum NGAL levels at ICU admission might be predictive of AKI development during ICU hospitalization. Further studies are needed to support NGAL as a prognostic marker of acute kidney injury.
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spelling pubmed-86251372021-11-27 Serum Neutrophil Gelatinase-Associated Lipocalin (NGAL) Could Provide Better Accuracy Than Creatinine in Predicting Acute Kidney Injury Development in Critically Ill Patients Jahaj, Edison Vassiliou, Alice G. Pratikaki, Maria Gallos, Parisis Mastora, Zafeiria Dimopoulou, Ioanna Orfanos, Stylianos E. Orfanos, Philippos Lagiou, Pagona Kotanidou, Anastasia J Clin Med Article Acute kidney injury (AKI) is one of the most common complications in critically ill patients. In recent years, studies have focused on exploring new biomarkers for the early diagnosis and prognosis of AKI. The aim of this study was to investigate serum prognostic biomarkers (neutrophil gelatinase-associated lipocalin, NGAL, and creatinine) of AKI in critically ill patients. The study included 266 critically ill, initially nonseptic, patients admitted to a multidisciplinary ICU. Serum levels of NGAL and creatinine were measured at ICU admission. ROC curves were generated to estimate the prognostic value of the biomarkers, while a logistic regression analysis was performed to assess their association with an increased AKI risk. Patients were divided in two groups based on the development (n = 98) or not (n = 168) of AKI during their ICU stay. Serum NGAL levels at ICU admission were significantly higher in those who subsequently developed AKI compared to those who did not (p < 0.0001). NGAL was shown to be more accurate in predicting AKI development than creatinine; furthermore, NGAL levels were associated with an increased risk of AKI development (1.005 (1.002–1.008), p < 0.0001). In the present study, we were able to demonstrate that increased serum NGAL levels at ICU admission might be predictive of AKI development during ICU hospitalization. Further studies are needed to support NGAL as a prognostic marker of acute kidney injury. MDPI 2021-11-18 /pmc/articles/PMC8625137/ /pubmed/34830657 http://dx.doi.org/10.3390/jcm10225379 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jahaj, Edison
Vassiliou, Alice G.
Pratikaki, Maria
Gallos, Parisis
Mastora, Zafeiria
Dimopoulou, Ioanna
Orfanos, Stylianos E.
Orfanos, Philippos
Lagiou, Pagona
Kotanidou, Anastasia
Serum Neutrophil Gelatinase-Associated Lipocalin (NGAL) Could Provide Better Accuracy Than Creatinine in Predicting Acute Kidney Injury Development in Critically Ill Patients
title Serum Neutrophil Gelatinase-Associated Lipocalin (NGAL) Could Provide Better Accuracy Than Creatinine in Predicting Acute Kidney Injury Development in Critically Ill Patients
title_full Serum Neutrophil Gelatinase-Associated Lipocalin (NGAL) Could Provide Better Accuracy Than Creatinine in Predicting Acute Kidney Injury Development in Critically Ill Patients
title_fullStr Serum Neutrophil Gelatinase-Associated Lipocalin (NGAL) Could Provide Better Accuracy Than Creatinine in Predicting Acute Kidney Injury Development in Critically Ill Patients
title_full_unstemmed Serum Neutrophil Gelatinase-Associated Lipocalin (NGAL) Could Provide Better Accuracy Than Creatinine in Predicting Acute Kidney Injury Development in Critically Ill Patients
title_short Serum Neutrophil Gelatinase-Associated Lipocalin (NGAL) Could Provide Better Accuracy Than Creatinine in Predicting Acute Kidney Injury Development in Critically Ill Patients
title_sort serum neutrophil gelatinase-associated lipocalin (ngal) could provide better accuracy than creatinine in predicting acute kidney injury development in critically ill patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8625137/
https://www.ncbi.nlm.nih.gov/pubmed/34830657
http://dx.doi.org/10.3390/jcm10225379
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