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Association of Plasma Branched-Chain and Aromatic Amino Acids with Reduction in Kidney Function Evaluated in Apparently Healthy Adults

The published literature on the association of circulatory branched-chain amino acids (BCAAs) and aromatic amino acids (AAAs) with reduced kidney function is inconsistent or conflicting. Clarification of it might help to better understand the underlying pathophysiology and to determine potential bio...

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Autores principales: Mahbub, MH, Yamaguchi, Natsu, Nakagami, Yuki, Hase, Ryosuke, Takahashi, Hidekazu, Ishimaru, Yasutaka, Watanabe, Rie, Saito, Hiroyuki, Shimokawa, Junki, Yamamoto, Hiroshi, Kikuchi, Shinya, Tanabe, Tsuyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8625145/
https://www.ncbi.nlm.nih.gov/pubmed/34830517
http://dx.doi.org/10.3390/jcm10225234
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author Mahbub, MH
Yamaguchi, Natsu
Nakagami, Yuki
Hase, Ryosuke
Takahashi, Hidekazu
Ishimaru, Yasutaka
Watanabe, Rie
Saito, Hiroyuki
Shimokawa, Junki
Yamamoto, Hiroshi
Kikuchi, Shinya
Tanabe, Tsuyoshi
author_facet Mahbub, MH
Yamaguchi, Natsu
Nakagami, Yuki
Hase, Ryosuke
Takahashi, Hidekazu
Ishimaru, Yasutaka
Watanabe, Rie
Saito, Hiroyuki
Shimokawa, Junki
Yamamoto, Hiroshi
Kikuchi, Shinya
Tanabe, Tsuyoshi
author_sort Mahbub, MH
collection PubMed
description The published literature on the association of circulatory branched-chain amino acids (BCAAs) and aromatic amino acids (AAAs) with reduced kidney function is inconsistent or conflicting. Clarification of it might help to better understand the underlying pathophysiology and to determine potential biomarkers for early detection and evaluation of kidney function decline. Our main purpose was to explore and clarify the potential relationships of individual BCAAs and AAAs with estimated glomerular filtration rate (eGFR) decline. We included the data from 2804 healthy subjects and categorized them into three groups based on eGFR tertiles. The associations between individual amino acids and eGFR were explored by covariate-adjusted logistic regression models. There was a progressive increase in the concentrations of BCAAs and AAAs from the upper to the lower tertiles. We revealed significant positive associations of isoleucine, leucine, and phenylalanine with lower tertiles of eGFR in the adjusted models (p < 0.01–0.001). The findings hold a promising potential of using plasma isoleucine, leucine, and phenylalanine levels for evaluation of kidney function decline. Future longitudinal studies should investigate the causal association between altered levels of these amino acids and impaired kidney function and also the utility of the former as potential biomarkers for evaluating the risk and early detection of the latter.
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spelling pubmed-86251452021-11-27 Association of Plasma Branched-Chain and Aromatic Amino Acids with Reduction in Kidney Function Evaluated in Apparently Healthy Adults Mahbub, MH Yamaguchi, Natsu Nakagami, Yuki Hase, Ryosuke Takahashi, Hidekazu Ishimaru, Yasutaka Watanabe, Rie Saito, Hiroyuki Shimokawa, Junki Yamamoto, Hiroshi Kikuchi, Shinya Tanabe, Tsuyoshi J Clin Med Article The published literature on the association of circulatory branched-chain amino acids (BCAAs) and aromatic amino acids (AAAs) with reduced kidney function is inconsistent or conflicting. Clarification of it might help to better understand the underlying pathophysiology and to determine potential biomarkers for early detection and evaluation of kidney function decline. Our main purpose was to explore and clarify the potential relationships of individual BCAAs and AAAs with estimated glomerular filtration rate (eGFR) decline. We included the data from 2804 healthy subjects and categorized them into three groups based on eGFR tertiles. The associations between individual amino acids and eGFR were explored by covariate-adjusted logistic regression models. There was a progressive increase in the concentrations of BCAAs and AAAs from the upper to the lower tertiles. We revealed significant positive associations of isoleucine, leucine, and phenylalanine with lower tertiles of eGFR in the adjusted models (p < 0.01–0.001). The findings hold a promising potential of using plasma isoleucine, leucine, and phenylalanine levels for evaluation of kidney function decline. Future longitudinal studies should investigate the causal association between altered levels of these amino acids and impaired kidney function and also the utility of the former as potential biomarkers for evaluating the risk and early detection of the latter. MDPI 2021-11-10 /pmc/articles/PMC8625145/ /pubmed/34830517 http://dx.doi.org/10.3390/jcm10225234 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mahbub, MH
Yamaguchi, Natsu
Nakagami, Yuki
Hase, Ryosuke
Takahashi, Hidekazu
Ishimaru, Yasutaka
Watanabe, Rie
Saito, Hiroyuki
Shimokawa, Junki
Yamamoto, Hiroshi
Kikuchi, Shinya
Tanabe, Tsuyoshi
Association of Plasma Branched-Chain and Aromatic Amino Acids with Reduction in Kidney Function Evaluated in Apparently Healthy Adults
title Association of Plasma Branched-Chain and Aromatic Amino Acids with Reduction in Kidney Function Evaluated in Apparently Healthy Adults
title_full Association of Plasma Branched-Chain and Aromatic Amino Acids with Reduction in Kidney Function Evaluated in Apparently Healthy Adults
title_fullStr Association of Plasma Branched-Chain and Aromatic Amino Acids with Reduction in Kidney Function Evaluated in Apparently Healthy Adults
title_full_unstemmed Association of Plasma Branched-Chain and Aromatic Amino Acids with Reduction in Kidney Function Evaluated in Apparently Healthy Adults
title_short Association of Plasma Branched-Chain and Aromatic Amino Acids with Reduction in Kidney Function Evaluated in Apparently Healthy Adults
title_sort association of plasma branched-chain and aromatic amino acids with reduction in kidney function evaluated in apparently healthy adults
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8625145/
https://www.ncbi.nlm.nih.gov/pubmed/34830517
http://dx.doi.org/10.3390/jcm10225234
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