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Failure Analysis of TEVG’s I: Overcoming the Initial Stages of Blood Material Interaction and Stabilization of the Immune Response
Vascular grafts (VG) are medical devices intended to replace the function of a diseased vessel. Current approaches use non-biodegradable materials that struggle to maintain patency under complex hemodynamic conditions. Even with the current advances in tissue engineering and regenerative medicine wi...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8625197/ https://www.ncbi.nlm.nih.gov/pubmed/34831361 http://dx.doi.org/10.3390/cells10113140 |
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author | Rodriguez-Soto, Maria A. Suarez Vargas, Natalia Riveros, Alejandra Camargo, Carolina Muñoz Cruz, Juan C. Sandoval, Nestor Briceño, Juan C. |
author_facet | Rodriguez-Soto, Maria A. Suarez Vargas, Natalia Riveros, Alejandra Camargo, Carolina Muñoz Cruz, Juan C. Sandoval, Nestor Briceño, Juan C. |
author_sort | Rodriguez-Soto, Maria A. |
collection | PubMed |
description | Vascular grafts (VG) are medical devices intended to replace the function of a diseased vessel. Current approaches use non-biodegradable materials that struggle to maintain patency under complex hemodynamic conditions. Even with the current advances in tissue engineering and regenerative medicine with the tissue engineered vascular grafts (TEVGs), the cellular response is not yet close to mimicking the biological function of native vessels, and the understanding of the interactions between cells from the blood and the vascular wall with the material in operative conditions is much needed. These interactions change over time after the implantation of the graft. Here we aim to analyze the current knowledge in bio-molecular interactions between blood components, cells and materials that lead either to an early failure or to the stabilization of the vascular graft before the wall regeneration begins. |
format | Online Article Text |
id | pubmed-8625197 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86251972021-11-27 Failure Analysis of TEVG’s I: Overcoming the Initial Stages of Blood Material Interaction and Stabilization of the Immune Response Rodriguez-Soto, Maria A. Suarez Vargas, Natalia Riveros, Alejandra Camargo, Carolina Muñoz Cruz, Juan C. Sandoval, Nestor Briceño, Juan C. Cells Review Vascular grafts (VG) are medical devices intended to replace the function of a diseased vessel. Current approaches use non-biodegradable materials that struggle to maintain patency under complex hemodynamic conditions. Even with the current advances in tissue engineering and regenerative medicine with the tissue engineered vascular grafts (TEVGs), the cellular response is not yet close to mimicking the biological function of native vessels, and the understanding of the interactions between cells from the blood and the vascular wall with the material in operative conditions is much needed. These interactions change over time after the implantation of the graft. Here we aim to analyze the current knowledge in bio-molecular interactions between blood components, cells and materials that lead either to an early failure or to the stabilization of the vascular graft before the wall regeneration begins. MDPI 2021-11-12 /pmc/articles/PMC8625197/ /pubmed/34831361 http://dx.doi.org/10.3390/cells10113140 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Rodriguez-Soto, Maria A. Suarez Vargas, Natalia Riveros, Alejandra Camargo, Carolina Muñoz Cruz, Juan C. Sandoval, Nestor Briceño, Juan C. Failure Analysis of TEVG’s I: Overcoming the Initial Stages of Blood Material Interaction and Stabilization of the Immune Response |
title | Failure Analysis of TEVG’s I: Overcoming the Initial Stages of Blood Material Interaction and Stabilization of the Immune Response |
title_full | Failure Analysis of TEVG’s I: Overcoming the Initial Stages of Blood Material Interaction and Stabilization of the Immune Response |
title_fullStr | Failure Analysis of TEVG’s I: Overcoming the Initial Stages of Blood Material Interaction and Stabilization of the Immune Response |
title_full_unstemmed | Failure Analysis of TEVG’s I: Overcoming the Initial Stages of Blood Material Interaction and Stabilization of the Immune Response |
title_short | Failure Analysis of TEVG’s I: Overcoming the Initial Stages of Blood Material Interaction and Stabilization of the Immune Response |
title_sort | failure analysis of tevg’s i: overcoming the initial stages of blood material interaction and stabilization of the immune response |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8625197/ https://www.ncbi.nlm.nih.gov/pubmed/34831361 http://dx.doi.org/10.3390/cells10113140 |
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