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Clinical Presentation of Celiac Disease and Diagnosis Accuracy in a Single-Center European Pediatric Cohort over 10 Years

(1) Background: Changes in the clinical presentation of celiac disease (CD) in children have been reported. The guidelines of the European Society of Pediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) allow esophagogastroduodenoscopy (EGD) with biopsies to be avoided under specific circu...

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Autores principales: Di Biase, Anna Rita, Marasco, Giovanni, Ravaioli, Federico, Colecchia, Luigi, Dajti, Elton, Lecis, Marco, Passini, Erica, Alemanni, Luigina Vanessa, Festi, Davide, Iughetti, Lorenzo, Colecchia, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8625284/
https://www.ncbi.nlm.nih.gov/pubmed/34836386
http://dx.doi.org/10.3390/nu13114131
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author Di Biase, Anna Rita
Marasco, Giovanni
Ravaioli, Federico
Colecchia, Luigi
Dajti, Elton
Lecis, Marco
Passini, Erica
Alemanni, Luigina Vanessa
Festi, Davide
Iughetti, Lorenzo
Colecchia, Antonio
author_facet Di Biase, Anna Rita
Marasco, Giovanni
Ravaioli, Federico
Colecchia, Luigi
Dajti, Elton
Lecis, Marco
Passini, Erica
Alemanni, Luigina Vanessa
Festi, Davide
Iughetti, Lorenzo
Colecchia, Antonio
author_sort Di Biase, Anna Rita
collection PubMed
description (1) Background: Changes in the clinical presentation of celiac disease (CD) in children have been reported. The guidelines of the European Society of Pediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) allow esophagogastroduodenoscopy (EGD) with biopsies to be avoided under specific circumstances. We aimed to assess the clinical picture of pediatric CD patients at diagnosis and to validate ESPGHAN non-biopsy criteria. (2) Methods: Patients with suspected CD or undergoing screening from 2004 to 2014 at the University Hospital in Modena, Italy were enrolled. The accuracy of ESPGHAN non-biopsy criteria and modified versions were assessed. (3) Results: In total, 410 patients were enrolled, of whom 403 were considered for analysis. Of the patients considered, 45 were asymptomatic and diagnosed with CD (11.2%) while 358 patients (88.2%) were symptomatic, of whom 295 were diagnosed with CD. Among symptomatic CD patients, 57 (19.3%) had gastrointestinal symptoms, 98 (33%) had atypical symptoms and 140 (47.4%) had both. No difference was found for the presence of gastrointestinal symptoms at different ages. The non-biopsy ESPGHAN criteria yielded an accuracy of 59.4% with a positive predictive value (PPV) of 100%; 173 out of 308 EGD (56.2%) could have been avoided. The modified 7× and 5× upper limit of normal cut-offs for IgA anti tissue-transglutaminase reached 60.7% and 64.3% of EGD avoided, respectively. (4) Conclusions: Over 10 years, late age at diagnosis and increased rates of atypical CD presentation were found. ESPGHAN non-biopsy criteria are accurate for CD diagnosis and allow half of unneeded EGD to be avoided. Modified versions allowed sparing a greater number of EGD.
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spelling pubmed-86252842021-11-27 Clinical Presentation of Celiac Disease and Diagnosis Accuracy in a Single-Center European Pediatric Cohort over 10 Years Di Biase, Anna Rita Marasco, Giovanni Ravaioli, Federico Colecchia, Luigi Dajti, Elton Lecis, Marco Passini, Erica Alemanni, Luigina Vanessa Festi, Davide Iughetti, Lorenzo Colecchia, Antonio Nutrients Article (1) Background: Changes in the clinical presentation of celiac disease (CD) in children have been reported. The guidelines of the European Society of Pediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) allow esophagogastroduodenoscopy (EGD) with biopsies to be avoided under specific circumstances. We aimed to assess the clinical picture of pediatric CD patients at diagnosis and to validate ESPGHAN non-biopsy criteria. (2) Methods: Patients with suspected CD or undergoing screening from 2004 to 2014 at the University Hospital in Modena, Italy were enrolled. The accuracy of ESPGHAN non-biopsy criteria and modified versions were assessed. (3) Results: In total, 410 patients were enrolled, of whom 403 were considered for analysis. Of the patients considered, 45 were asymptomatic and diagnosed with CD (11.2%) while 358 patients (88.2%) were symptomatic, of whom 295 were diagnosed with CD. Among symptomatic CD patients, 57 (19.3%) had gastrointestinal symptoms, 98 (33%) had atypical symptoms and 140 (47.4%) had both. No difference was found for the presence of gastrointestinal symptoms at different ages. The non-biopsy ESPGHAN criteria yielded an accuracy of 59.4% with a positive predictive value (PPV) of 100%; 173 out of 308 EGD (56.2%) could have been avoided. The modified 7× and 5× upper limit of normal cut-offs for IgA anti tissue-transglutaminase reached 60.7% and 64.3% of EGD avoided, respectively. (4) Conclusions: Over 10 years, late age at diagnosis and increased rates of atypical CD presentation were found. ESPGHAN non-biopsy criteria are accurate for CD diagnosis and allow half of unneeded EGD to be avoided. Modified versions allowed sparing a greater number of EGD. MDPI 2021-11-18 /pmc/articles/PMC8625284/ /pubmed/34836386 http://dx.doi.org/10.3390/nu13114131 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Di Biase, Anna Rita
Marasco, Giovanni
Ravaioli, Federico
Colecchia, Luigi
Dajti, Elton
Lecis, Marco
Passini, Erica
Alemanni, Luigina Vanessa
Festi, Davide
Iughetti, Lorenzo
Colecchia, Antonio
Clinical Presentation of Celiac Disease and Diagnosis Accuracy in a Single-Center European Pediatric Cohort over 10 Years
title Clinical Presentation of Celiac Disease and Diagnosis Accuracy in a Single-Center European Pediatric Cohort over 10 Years
title_full Clinical Presentation of Celiac Disease and Diagnosis Accuracy in a Single-Center European Pediatric Cohort over 10 Years
title_fullStr Clinical Presentation of Celiac Disease and Diagnosis Accuracy in a Single-Center European Pediatric Cohort over 10 Years
title_full_unstemmed Clinical Presentation of Celiac Disease and Diagnosis Accuracy in a Single-Center European Pediatric Cohort over 10 Years
title_short Clinical Presentation of Celiac Disease and Diagnosis Accuracy in a Single-Center European Pediatric Cohort over 10 Years
title_sort clinical presentation of celiac disease and diagnosis accuracy in a single-center european pediatric cohort over 10 years
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8625284/
https://www.ncbi.nlm.nih.gov/pubmed/34836386
http://dx.doi.org/10.3390/nu13114131
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