Cargando…
Long-Term Outcomes after Neonatal Hypoxic-Ischemic Encephalopathy in the Era of Therapeutic Hypothermia: A Longitudinal, Prospective, Multicenter Case-Control Study in Children without Overt Brain Damage
Background. Data on long-term outcomes in the era before therapeutic hypothermia (TH) showed a higher incidence of cognitive problems. Since the introduction of TH, data on its results are limited. Methods. Our sample population consisted of 40 children with a history of hypoxic-ischemic encephalopa...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8625352/ https://www.ncbi.nlm.nih.gov/pubmed/34828791 http://dx.doi.org/10.3390/children8111076 |
_version_ | 1784606400357335040 |
---|---|
author | Cainelli, Elisa Vedovelli, Luca Mastretta, Emmanuele Gregori, Dario Suppiej, Agnese Bisiacchi, Patrizia Silvia |
author_facet | Cainelli, Elisa Vedovelli, Luca Mastretta, Emmanuele Gregori, Dario Suppiej, Agnese Bisiacchi, Patrizia Silvia |
author_sort | Cainelli, Elisa |
collection | PubMed |
description | Background. Data on long-term outcomes in the era before therapeutic hypothermia (TH) showed a higher incidence of cognitive problems. Since the introduction of TH, data on its results are limited. Methods. Our sample population consisted of 40 children with a history of hypoxic-ischemic encephalopathy (HIE) treated with TH, with an average age of 6.25 years (range 5.5, 7.33), 24 (60%) males; and 33 peers with an average age of 8.8 years (6.08, 9.41), 17 (51%) males. Long-term follow-up data belong to two centers in Padova and Torino. We measured general intelligence (WPPSI-III or WISC-IV) and neuropsychological functioning (language, attention, memory, executive functions, social skills, visual motor abilities). We also administered questionnaires to their parents on the children’s psychopathological profiles and parental stress. Results. We found differences between groups in several cognitive and neuropsychological domains: intelligence, visuomotor skills, executive functions, and attention. Interestingly, IQ test results effectively differentiated between the groups (HIE vs. controls). Furthermore, the incidence of psychopathology appears to be significantly higher in children with HIE (35%) than in control peers (12%). Conclusions. Our study supports previous findings on a higher incidence of neuropsychological, cognitive, and psychopathological sequelae after HIE treated with TH. As hypothesized, TH does not appear to ameliorate the outcome after neonatal HIE in those children who survive without major sequelae. |
format | Online Article Text |
id | pubmed-8625352 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86253522021-11-27 Long-Term Outcomes after Neonatal Hypoxic-Ischemic Encephalopathy in the Era of Therapeutic Hypothermia: A Longitudinal, Prospective, Multicenter Case-Control Study in Children without Overt Brain Damage Cainelli, Elisa Vedovelli, Luca Mastretta, Emmanuele Gregori, Dario Suppiej, Agnese Bisiacchi, Patrizia Silvia Children (Basel) Article Background. Data on long-term outcomes in the era before therapeutic hypothermia (TH) showed a higher incidence of cognitive problems. Since the introduction of TH, data on its results are limited. Methods. Our sample population consisted of 40 children with a history of hypoxic-ischemic encephalopathy (HIE) treated with TH, with an average age of 6.25 years (range 5.5, 7.33), 24 (60%) males; and 33 peers with an average age of 8.8 years (6.08, 9.41), 17 (51%) males. Long-term follow-up data belong to two centers in Padova and Torino. We measured general intelligence (WPPSI-III or WISC-IV) and neuropsychological functioning (language, attention, memory, executive functions, social skills, visual motor abilities). We also administered questionnaires to their parents on the children’s psychopathological profiles and parental stress. Results. We found differences between groups in several cognitive and neuropsychological domains: intelligence, visuomotor skills, executive functions, and attention. Interestingly, IQ test results effectively differentiated between the groups (HIE vs. controls). Furthermore, the incidence of psychopathology appears to be significantly higher in children with HIE (35%) than in control peers (12%). Conclusions. Our study supports previous findings on a higher incidence of neuropsychological, cognitive, and psychopathological sequelae after HIE treated with TH. As hypothesized, TH does not appear to ameliorate the outcome after neonatal HIE in those children who survive without major sequelae. MDPI 2021-11-22 /pmc/articles/PMC8625352/ /pubmed/34828791 http://dx.doi.org/10.3390/children8111076 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Cainelli, Elisa Vedovelli, Luca Mastretta, Emmanuele Gregori, Dario Suppiej, Agnese Bisiacchi, Patrizia Silvia Long-Term Outcomes after Neonatal Hypoxic-Ischemic Encephalopathy in the Era of Therapeutic Hypothermia: A Longitudinal, Prospective, Multicenter Case-Control Study in Children without Overt Brain Damage |
title | Long-Term Outcomes after Neonatal Hypoxic-Ischemic Encephalopathy in the Era of Therapeutic Hypothermia: A Longitudinal, Prospective, Multicenter Case-Control Study in Children without Overt Brain Damage |
title_full | Long-Term Outcomes after Neonatal Hypoxic-Ischemic Encephalopathy in the Era of Therapeutic Hypothermia: A Longitudinal, Prospective, Multicenter Case-Control Study in Children without Overt Brain Damage |
title_fullStr | Long-Term Outcomes after Neonatal Hypoxic-Ischemic Encephalopathy in the Era of Therapeutic Hypothermia: A Longitudinal, Prospective, Multicenter Case-Control Study in Children without Overt Brain Damage |
title_full_unstemmed | Long-Term Outcomes after Neonatal Hypoxic-Ischemic Encephalopathy in the Era of Therapeutic Hypothermia: A Longitudinal, Prospective, Multicenter Case-Control Study in Children without Overt Brain Damage |
title_short | Long-Term Outcomes after Neonatal Hypoxic-Ischemic Encephalopathy in the Era of Therapeutic Hypothermia: A Longitudinal, Prospective, Multicenter Case-Control Study in Children without Overt Brain Damage |
title_sort | long-term outcomes after neonatal hypoxic-ischemic encephalopathy in the era of therapeutic hypothermia: a longitudinal, prospective, multicenter case-control study in children without overt brain damage |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8625352/ https://www.ncbi.nlm.nih.gov/pubmed/34828791 http://dx.doi.org/10.3390/children8111076 |
work_keys_str_mv | AT cainellielisa longtermoutcomesafterneonatalhypoxicischemicencephalopathyintheeraoftherapeutichypothermiaalongitudinalprospectivemulticentercasecontrolstudyinchildrenwithoutovertbraindamage AT vedovelliluca longtermoutcomesafterneonatalhypoxicischemicencephalopathyintheeraoftherapeutichypothermiaalongitudinalprospectivemulticentercasecontrolstudyinchildrenwithoutovertbraindamage AT mastrettaemmanuele longtermoutcomesafterneonatalhypoxicischemicencephalopathyintheeraoftherapeutichypothermiaalongitudinalprospectivemulticentercasecontrolstudyinchildrenwithoutovertbraindamage AT gregoridario longtermoutcomesafterneonatalhypoxicischemicencephalopathyintheeraoftherapeutichypothermiaalongitudinalprospectivemulticentercasecontrolstudyinchildrenwithoutovertbraindamage AT suppiejagnese longtermoutcomesafterneonatalhypoxicischemicencephalopathyintheeraoftherapeutichypothermiaalongitudinalprospectivemulticentercasecontrolstudyinchildrenwithoutovertbraindamage AT bisiacchipatriziasilvia longtermoutcomesafterneonatalhypoxicischemicencephalopathyintheeraoftherapeutichypothermiaalongitudinalprospectivemulticentercasecontrolstudyinchildrenwithoutovertbraindamage |