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Alpha-Synuclein and Cognitive Decline in Parkinson Disease

Parkinson disease (PD) is the second most common neurodegenerative disorder in elderly people. It is characterized by the aggregation of misfolded alpha-synuclein throughout the nervous system. Aside from cardinal motor symptoms, cognitive impairment is one of the most disabling non-motor symptoms t...

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Autores principales: Fan, Tian-Sin, Liu, Sam Chi-Hao, Wu, Ruey-Meei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8625417/
https://www.ncbi.nlm.nih.gov/pubmed/34833115
http://dx.doi.org/10.3390/life11111239
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author Fan, Tian-Sin
Liu, Sam Chi-Hao
Wu, Ruey-Meei
author_facet Fan, Tian-Sin
Liu, Sam Chi-Hao
Wu, Ruey-Meei
author_sort Fan, Tian-Sin
collection PubMed
description Parkinson disease (PD) is the second most common neurodegenerative disorder in elderly people. It is characterized by the aggregation of misfolded alpha-synuclein throughout the nervous system. Aside from cardinal motor symptoms, cognitive impairment is one of the most disabling non-motor symptoms that occurs during the progression of the disease. The accumulation and spreading of alpha-synuclein pathology from the brainstem to limbic and neocortical structures is correlated with emerging cognitive decline in PD. This review summarizes the genetic and pathophysiologic relationship between alpha-synuclein and cognitive impairment in PD, together with potential areas of biomarker advancement.
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spelling pubmed-86254172021-11-27 Alpha-Synuclein and Cognitive Decline in Parkinson Disease Fan, Tian-Sin Liu, Sam Chi-Hao Wu, Ruey-Meei Life (Basel) Review Parkinson disease (PD) is the second most common neurodegenerative disorder in elderly people. It is characterized by the aggregation of misfolded alpha-synuclein throughout the nervous system. Aside from cardinal motor symptoms, cognitive impairment is one of the most disabling non-motor symptoms that occurs during the progression of the disease. The accumulation and spreading of alpha-synuclein pathology from the brainstem to limbic and neocortical structures is correlated with emerging cognitive decline in PD. This review summarizes the genetic and pathophysiologic relationship between alpha-synuclein and cognitive impairment in PD, together with potential areas of biomarker advancement. MDPI 2021-11-16 /pmc/articles/PMC8625417/ /pubmed/34833115 http://dx.doi.org/10.3390/life11111239 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Fan, Tian-Sin
Liu, Sam Chi-Hao
Wu, Ruey-Meei
Alpha-Synuclein and Cognitive Decline in Parkinson Disease
title Alpha-Synuclein and Cognitive Decline in Parkinson Disease
title_full Alpha-Synuclein and Cognitive Decline in Parkinson Disease
title_fullStr Alpha-Synuclein and Cognitive Decline in Parkinson Disease
title_full_unstemmed Alpha-Synuclein and Cognitive Decline in Parkinson Disease
title_short Alpha-Synuclein and Cognitive Decline in Parkinson Disease
title_sort alpha-synuclein and cognitive decline in parkinson disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8625417/
https://www.ncbi.nlm.nih.gov/pubmed/34833115
http://dx.doi.org/10.3390/life11111239
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