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Alpha-Synuclein and Cognitive Decline in Parkinson Disease
Parkinson disease (PD) is the second most common neurodegenerative disorder in elderly people. It is characterized by the aggregation of misfolded alpha-synuclein throughout the nervous system. Aside from cardinal motor symptoms, cognitive impairment is one of the most disabling non-motor symptoms t...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8625417/ https://www.ncbi.nlm.nih.gov/pubmed/34833115 http://dx.doi.org/10.3390/life11111239 |
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author | Fan, Tian-Sin Liu, Sam Chi-Hao Wu, Ruey-Meei |
author_facet | Fan, Tian-Sin Liu, Sam Chi-Hao Wu, Ruey-Meei |
author_sort | Fan, Tian-Sin |
collection | PubMed |
description | Parkinson disease (PD) is the second most common neurodegenerative disorder in elderly people. It is characterized by the aggregation of misfolded alpha-synuclein throughout the nervous system. Aside from cardinal motor symptoms, cognitive impairment is one of the most disabling non-motor symptoms that occurs during the progression of the disease. The accumulation and spreading of alpha-synuclein pathology from the brainstem to limbic and neocortical structures is correlated with emerging cognitive decline in PD. This review summarizes the genetic and pathophysiologic relationship between alpha-synuclein and cognitive impairment in PD, together with potential areas of biomarker advancement. |
format | Online Article Text |
id | pubmed-8625417 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86254172021-11-27 Alpha-Synuclein and Cognitive Decline in Parkinson Disease Fan, Tian-Sin Liu, Sam Chi-Hao Wu, Ruey-Meei Life (Basel) Review Parkinson disease (PD) is the second most common neurodegenerative disorder in elderly people. It is characterized by the aggregation of misfolded alpha-synuclein throughout the nervous system. Aside from cardinal motor symptoms, cognitive impairment is one of the most disabling non-motor symptoms that occurs during the progression of the disease. The accumulation and spreading of alpha-synuclein pathology from the brainstem to limbic and neocortical structures is correlated with emerging cognitive decline in PD. This review summarizes the genetic and pathophysiologic relationship between alpha-synuclein and cognitive impairment in PD, together with potential areas of biomarker advancement. MDPI 2021-11-16 /pmc/articles/PMC8625417/ /pubmed/34833115 http://dx.doi.org/10.3390/life11111239 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Fan, Tian-Sin Liu, Sam Chi-Hao Wu, Ruey-Meei Alpha-Synuclein and Cognitive Decline in Parkinson Disease |
title | Alpha-Synuclein and Cognitive Decline in Parkinson Disease |
title_full | Alpha-Synuclein and Cognitive Decline in Parkinson Disease |
title_fullStr | Alpha-Synuclein and Cognitive Decline in Parkinson Disease |
title_full_unstemmed | Alpha-Synuclein and Cognitive Decline in Parkinson Disease |
title_short | Alpha-Synuclein and Cognitive Decline in Parkinson Disease |
title_sort | alpha-synuclein and cognitive decline in parkinson disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8625417/ https://www.ncbi.nlm.nih.gov/pubmed/34833115 http://dx.doi.org/10.3390/life11111239 |
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