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RNA Binding Proteins as Pioneer Determinants of Infection: Protective, Proviral, or Both?
As the first intracellular host factors that directly interact with the genomes of RNA viruses, RNA binding proteins (RBPs) have a profound impact on the outcome of an infection. Recent discoveries brought about by new methodologies have led to an unprecedented ability to peer into the earliest even...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8625426/ https://www.ncbi.nlm.nih.gov/pubmed/34834978 http://dx.doi.org/10.3390/v13112172 |
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author | Lisy, Samantha Rothamel, Katherine Ascano, Manuel |
author_facet | Lisy, Samantha Rothamel, Katherine Ascano, Manuel |
author_sort | Lisy, Samantha |
collection | PubMed |
description | As the first intracellular host factors that directly interact with the genomes of RNA viruses, RNA binding proteins (RBPs) have a profound impact on the outcome of an infection. Recent discoveries brought about by new methodologies have led to an unprecedented ability to peer into the earliest events between viral RNA and the RBPs that act upon them. These discoveries have sparked a re-evaluation of current paradigms surrounding RBPs and post-transcriptional gene regulation. Here, we highlight questions that have bloomed from the implementation of these novel approaches. Canonical RBPs can impact the fates of both cellular and viral RNA during infection, sometimes in conflicting ways. Noncanonical RBPs, some of which were first characterized via interactions with viral RNA, may encompass physiological roles beyond viral pathogenesis. We discuss how these RBPs might discriminate between an RNA of either cellular or viral origin and thus exert either pro- or antiviral effects—which is a particular challenge as viruses contain mechanisms to mimic molecular features of cellular RNA. |
format | Online Article Text |
id | pubmed-8625426 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86254262021-11-27 RNA Binding Proteins as Pioneer Determinants of Infection: Protective, Proviral, or Both? Lisy, Samantha Rothamel, Katherine Ascano, Manuel Viruses Review As the first intracellular host factors that directly interact with the genomes of RNA viruses, RNA binding proteins (RBPs) have a profound impact on the outcome of an infection. Recent discoveries brought about by new methodologies have led to an unprecedented ability to peer into the earliest events between viral RNA and the RBPs that act upon them. These discoveries have sparked a re-evaluation of current paradigms surrounding RBPs and post-transcriptional gene regulation. Here, we highlight questions that have bloomed from the implementation of these novel approaches. Canonical RBPs can impact the fates of both cellular and viral RNA during infection, sometimes in conflicting ways. Noncanonical RBPs, some of which were first characterized via interactions with viral RNA, may encompass physiological roles beyond viral pathogenesis. We discuss how these RBPs might discriminate between an RNA of either cellular or viral origin and thus exert either pro- or antiviral effects—which is a particular challenge as viruses contain mechanisms to mimic molecular features of cellular RNA. MDPI 2021-10-28 /pmc/articles/PMC8625426/ /pubmed/34834978 http://dx.doi.org/10.3390/v13112172 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Lisy, Samantha Rothamel, Katherine Ascano, Manuel RNA Binding Proteins as Pioneer Determinants of Infection: Protective, Proviral, or Both? |
title | RNA Binding Proteins as Pioneer Determinants of Infection: Protective, Proviral, or Both? |
title_full | RNA Binding Proteins as Pioneer Determinants of Infection: Protective, Proviral, or Both? |
title_fullStr | RNA Binding Proteins as Pioneer Determinants of Infection: Protective, Proviral, or Both? |
title_full_unstemmed | RNA Binding Proteins as Pioneer Determinants of Infection: Protective, Proviral, or Both? |
title_short | RNA Binding Proteins as Pioneer Determinants of Infection: Protective, Proviral, or Both? |
title_sort | rna binding proteins as pioneer determinants of infection: protective, proviral, or both? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8625426/ https://www.ncbi.nlm.nih.gov/pubmed/34834978 http://dx.doi.org/10.3390/v13112172 |
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