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Dynamics of Viral Shedding and Symptoms in Patients with Asymptomatic or Mild COVID-19
We conducted a prospective cohort study at a community facility designated for the isolation of individuals with asymptomatic or mild COVID-19 between 10 January and 22 February 2021 to investigate the relationship of viral shedding with symptom changes of COVID-19. In total, 89 COVID-19 adult patie...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8625453/ https://www.ncbi.nlm.nih.gov/pubmed/34834940 http://dx.doi.org/10.3390/v13112133 |
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author | Bae, Seongman Kim, Ji Yeun Lim, So Yun Park, Heedo Cha, Hye Hee Kwon, Ji-Soo Suh, Mi Hyun Lee, Hyun Jung Lim, Joon Seo Jung, Jiwon Kim, Min Jae Chong, Yong Pil Lee, Sang-Oh Choi, Sang-Ho Kim, Yang Soo Lee, Ho Young Lee, Sohyun Park, Man-Seong Kim, Sung-Han |
author_facet | Bae, Seongman Kim, Ji Yeun Lim, So Yun Park, Heedo Cha, Hye Hee Kwon, Ji-Soo Suh, Mi Hyun Lee, Hyun Jung Lim, Joon Seo Jung, Jiwon Kim, Min Jae Chong, Yong Pil Lee, Sang-Oh Choi, Sang-Ho Kim, Yang Soo Lee, Ho Young Lee, Sohyun Park, Man-Seong Kim, Sung-Han |
author_sort | Bae, Seongman |
collection | PubMed |
description | We conducted a prospective cohort study at a community facility designated for the isolation of individuals with asymptomatic or mild COVID-19 between 10 January and 22 February 2021 to investigate the relationship of viral shedding with symptom changes of COVID-19. In total, 89 COVID-19 adult patients (12 asymptomatic, 16 presymptomatic, 61 symptomatic) were enrolled. Symptom scores, the genomic RNA and subgenomic RNA of SARS-CoV-2 from saliva samples with a cell culture were measured. Asymptomatic COVID-19 patients had a similar viral load to symptomatic patients during the early course of the disease, but exhibited a rapid decrease in viral load with the loss of infectivity. Subgenomic RNA and viable virus by cell culture in asymptomatic patients were detected only until 3 days after diagnosis, and the positivity of the subgenomic RNA and cell culture in symptomatic patients gradually decreased in both from 40% in the early disease course to 13% at 10 days and 4% at 8 days after the symptom onset, respectively. In conclusion, symptomatic patients have a high infectivity with high symptom scores during the early disease course and gradually lose infectivity depending on the symptom. Conversely, asymptomatic patients exhibit a rapid decrease in viral load with the loss of infectivity, despite a similar viral load during the early disease course. |
format | Online Article Text |
id | pubmed-8625453 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86254532021-11-27 Dynamics of Viral Shedding and Symptoms in Patients with Asymptomatic or Mild COVID-19 Bae, Seongman Kim, Ji Yeun Lim, So Yun Park, Heedo Cha, Hye Hee Kwon, Ji-Soo Suh, Mi Hyun Lee, Hyun Jung Lim, Joon Seo Jung, Jiwon Kim, Min Jae Chong, Yong Pil Lee, Sang-Oh Choi, Sang-Ho Kim, Yang Soo Lee, Ho Young Lee, Sohyun Park, Man-Seong Kim, Sung-Han Viruses Article We conducted a prospective cohort study at a community facility designated for the isolation of individuals with asymptomatic or mild COVID-19 between 10 January and 22 February 2021 to investigate the relationship of viral shedding with symptom changes of COVID-19. In total, 89 COVID-19 adult patients (12 asymptomatic, 16 presymptomatic, 61 symptomatic) were enrolled. Symptom scores, the genomic RNA and subgenomic RNA of SARS-CoV-2 from saliva samples with a cell culture were measured. Asymptomatic COVID-19 patients had a similar viral load to symptomatic patients during the early course of the disease, but exhibited a rapid decrease in viral load with the loss of infectivity. Subgenomic RNA and viable virus by cell culture in asymptomatic patients were detected only until 3 days after diagnosis, and the positivity of the subgenomic RNA and cell culture in symptomatic patients gradually decreased in both from 40% in the early disease course to 13% at 10 days and 4% at 8 days after the symptom onset, respectively. In conclusion, symptomatic patients have a high infectivity with high symptom scores during the early disease course and gradually lose infectivity depending on the symptom. Conversely, asymptomatic patients exhibit a rapid decrease in viral load with the loss of infectivity, despite a similar viral load during the early disease course. MDPI 2021-10-22 /pmc/articles/PMC8625453/ /pubmed/34834940 http://dx.doi.org/10.3390/v13112133 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Bae, Seongman Kim, Ji Yeun Lim, So Yun Park, Heedo Cha, Hye Hee Kwon, Ji-Soo Suh, Mi Hyun Lee, Hyun Jung Lim, Joon Seo Jung, Jiwon Kim, Min Jae Chong, Yong Pil Lee, Sang-Oh Choi, Sang-Ho Kim, Yang Soo Lee, Ho Young Lee, Sohyun Park, Man-Seong Kim, Sung-Han Dynamics of Viral Shedding and Symptoms in Patients with Asymptomatic or Mild COVID-19 |
title | Dynamics of Viral Shedding and Symptoms in Patients with Asymptomatic or Mild COVID-19 |
title_full | Dynamics of Viral Shedding and Symptoms in Patients with Asymptomatic or Mild COVID-19 |
title_fullStr | Dynamics of Viral Shedding and Symptoms in Patients with Asymptomatic or Mild COVID-19 |
title_full_unstemmed | Dynamics of Viral Shedding and Symptoms in Patients with Asymptomatic or Mild COVID-19 |
title_short | Dynamics of Viral Shedding and Symptoms in Patients with Asymptomatic or Mild COVID-19 |
title_sort | dynamics of viral shedding and symptoms in patients with asymptomatic or mild covid-19 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8625453/ https://www.ncbi.nlm.nih.gov/pubmed/34834940 http://dx.doi.org/10.3390/v13112133 |
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