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Dynamics of Viral Shedding and Symptoms in Patients with Asymptomatic or Mild COVID-19

We conducted a prospective cohort study at a community facility designated for the isolation of individuals with asymptomatic or mild COVID-19 between 10 January and 22 February 2021 to investigate the relationship of viral shedding with symptom changes of COVID-19. In total, 89 COVID-19 adult patie...

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Autores principales: Bae, Seongman, Kim, Ji Yeun, Lim, So Yun, Park, Heedo, Cha, Hye Hee, Kwon, Ji-Soo, Suh, Mi Hyun, Lee, Hyun Jung, Lim, Joon Seo, Jung, Jiwon, Kim, Min Jae, Chong, Yong Pil, Lee, Sang-Oh, Choi, Sang-Ho, Kim, Yang Soo, Lee, Ho Young, Lee, Sohyun, Park, Man-Seong, Kim, Sung-Han
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8625453/
https://www.ncbi.nlm.nih.gov/pubmed/34834940
http://dx.doi.org/10.3390/v13112133
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author Bae, Seongman
Kim, Ji Yeun
Lim, So Yun
Park, Heedo
Cha, Hye Hee
Kwon, Ji-Soo
Suh, Mi Hyun
Lee, Hyun Jung
Lim, Joon Seo
Jung, Jiwon
Kim, Min Jae
Chong, Yong Pil
Lee, Sang-Oh
Choi, Sang-Ho
Kim, Yang Soo
Lee, Ho Young
Lee, Sohyun
Park, Man-Seong
Kim, Sung-Han
author_facet Bae, Seongman
Kim, Ji Yeun
Lim, So Yun
Park, Heedo
Cha, Hye Hee
Kwon, Ji-Soo
Suh, Mi Hyun
Lee, Hyun Jung
Lim, Joon Seo
Jung, Jiwon
Kim, Min Jae
Chong, Yong Pil
Lee, Sang-Oh
Choi, Sang-Ho
Kim, Yang Soo
Lee, Ho Young
Lee, Sohyun
Park, Man-Seong
Kim, Sung-Han
author_sort Bae, Seongman
collection PubMed
description We conducted a prospective cohort study at a community facility designated for the isolation of individuals with asymptomatic or mild COVID-19 between 10 January and 22 February 2021 to investigate the relationship of viral shedding with symptom changes of COVID-19. In total, 89 COVID-19 adult patients (12 asymptomatic, 16 presymptomatic, 61 symptomatic) were enrolled. Symptom scores, the genomic RNA and subgenomic RNA of SARS-CoV-2 from saliva samples with a cell culture were measured. Asymptomatic COVID-19 patients had a similar viral load to symptomatic patients during the early course of the disease, but exhibited a rapid decrease in viral load with the loss of infectivity. Subgenomic RNA and viable virus by cell culture in asymptomatic patients were detected only until 3 days after diagnosis, and the positivity of the subgenomic RNA and cell culture in symptomatic patients gradually decreased in both from 40% in the early disease course to 13% at 10 days and 4% at 8 days after the symptom onset, respectively. In conclusion, symptomatic patients have a high infectivity with high symptom scores during the early disease course and gradually lose infectivity depending on the symptom. Conversely, asymptomatic patients exhibit a rapid decrease in viral load with the loss of infectivity, despite a similar viral load during the early disease course.
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spelling pubmed-86254532021-11-27 Dynamics of Viral Shedding and Symptoms in Patients with Asymptomatic or Mild COVID-19 Bae, Seongman Kim, Ji Yeun Lim, So Yun Park, Heedo Cha, Hye Hee Kwon, Ji-Soo Suh, Mi Hyun Lee, Hyun Jung Lim, Joon Seo Jung, Jiwon Kim, Min Jae Chong, Yong Pil Lee, Sang-Oh Choi, Sang-Ho Kim, Yang Soo Lee, Ho Young Lee, Sohyun Park, Man-Seong Kim, Sung-Han Viruses Article We conducted a prospective cohort study at a community facility designated for the isolation of individuals with asymptomatic or mild COVID-19 between 10 January and 22 February 2021 to investigate the relationship of viral shedding with symptom changes of COVID-19. In total, 89 COVID-19 adult patients (12 asymptomatic, 16 presymptomatic, 61 symptomatic) were enrolled. Symptom scores, the genomic RNA and subgenomic RNA of SARS-CoV-2 from saliva samples with a cell culture were measured. Asymptomatic COVID-19 patients had a similar viral load to symptomatic patients during the early course of the disease, but exhibited a rapid decrease in viral load with the loss of infectivity. Subgenomic RNA and viable virus by cell culture in asymptomatic patients were detected only until 3 days after diagnosis, and the positivity of the subgenomic RNA and cell culture in symptomatic patients gradually decreased in both from 40% in the early disease course to 13% at 10 days and 4% at 8 days after the symptom onset, respectively. In conclusion, symptomatic patients have a high infectivity with high symptom scores during the early disease course and gradually lose infectivity depending on the symptom. Conversely, asymptomatic patients exhibit a rapid decrease in viral load with the loss of infectivity, despite a similar viral load during the early disease course. MDPI 2021-10-22 /pmc/articles/PMC8625453/ /pubmed/34834940 http://dx.doi.org/10.3390/v13112133 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bae, Seongman
Kim, Ji Yeun
Lim, So Yun
Park, Heedo
Cha, Hye Hee
Kwon, Ji-Soo
Suh, Mi Hyun
Lee, Hyun Jung
Lim, Joon Seo
Jung, Jiwon
Kim, Min Jae
Chong, Yong Pil
Lee, Sang-Oh
Choi, Sang-Ho
Kim, Yang Soo
Lee, Ho Young
Lee, Sohyun
Park, Man-Seong
Kim, Sung-Han
Dynamics of Viral Shedding and Symptoms in Patients with Asymptomatic or Mild COVID-19
title Dynamics of Viral Shedding and Symptoms in Patients with Asymptomatic or Mild COVID-19
title_full Dynamics of Viral Shedding and Symptoms in Patients with Asymptomatic or Mild COVID-19
title_fullStr Dynamics of Viral Shedding and Symptoms in Patients with Asymptomatic or Mild COVID-19
title_full_unstemmed Dynamics of Viral Shedding and Symptoms in Patients with Asymptomatic or Mild COVID-19
title_short Dynamics of Viral Shedding and Symptoms in Patients with Asymptomatic or Mild COVID-19
title_sort dynamics of viral shedding and symptoms in patients with asymptomatic or mild covid-19
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8625453/
https://www.ncbi.nlm.nih.gov/pubmed/34834940
http://dx.doi.org/10.3390/v13112133
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