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Leaky Gut Syndrome Is Associated with Endotoxemia and Serum (1→3)-β-D-Glucan in Severe Dengue Infection

The hallmark of severe dengue infection is the increased vascular permeability and hemodynamic alteration that might be associated with an intestinal permeability defect. However, the mechanisms underlying the gastrointestinal-related symptoms of dengue are not well characterized. A prospective obse...

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Autores principales: Chancharoenthana, Wiwat, Leelahavanichkul, Asada, Ariyanon, Wassawon, Vadcharavivad, Somratai, Phatcharophaswattanakul, Suphasit, Kamolratanakul, Supitcha, Leaungwutiwong, Pornsawan, Phumratanaprapin, Weerapong, Wilairatana, Polrat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8625530/
https://www.ncbi.nlm.nih.gov/pubmed/34835514
http://dx.doi.org/10.3390/microorganisms9112390
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author Chancharoenthana, Wiwat
Leelahavanichkul, Asada
Ariyanon, Wassawon
Vadcharavivad, Somratai
Phatcharophaswattanakul, Suphasit
Kamolratanakul, Supitcha
Leaungwutiwong, Pornsawan
Phumratanaprapin, Weerapong
Wilairatana, Polrat
author_facet Chancharoenthana, Wiwat
Leelahavanichkul, Asada
Ariyanon, Wassawon
Vadcharavivad, Somratai
Phatcharophaswattanakul, Suphasit
Kamolratanakul, Supitcha
Leaungwutiwong, Pornsawan
Phumratanaprapin, Weerapong
Wilairatana, Polrat
author_sort Chancharoenthana, Wiwat
collection PubMed
description The hallmark of severe dengue infection is the increased vascular permeability and hemodynamic alteration that might be associated with an intestinal permeability defect. However, the mechanisms underlying the gastrointestinal-related symptoms of dengue are not well characterized. A prospective observational study was conducted on patients with dengue who were categorized according to: (i) febrile versus critical phase and (ii) hospitalized patients with versus without the warning signs to evaluate the gut barrier using lactulose-to-mannitol excretion ratio (LEMR). Serum endotoxins, (1→3)-β-D-glucan (BG), and inflammatory parameters were measured. A total of 48 and 38 patients were enrolled in febrile illness and critical phase, respectively, while 22 and 64 patients presented with or without the warning signs, respectively. At enrollment, a positive LEMR test was found in 20 patients (91%) with warning signs, regardless of phase of infection. Likewise, serum endotoxins and BG, the indirect biomarkers for leaky gut, prominently increased in patients who developed severe dengue when compared with the non-severe dengue (endotoxins, 399.1 versus 143.4 pg/mL (p < 0.0001); BG, 123 versus 73.8 pg/mL (p = 0.016)). Modest impaired intestinal permeability occurred in dengue patients, particularly those with warning signs, and were associated with endotoxemia and elevated BG. Thus, leaky gut syndrome might be associated with severity of dengue infection.
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spelling pubmed-86255302021-11-27 Leaky Gut Syndrome Is Associated with Endotoxemia and Serum (1→3)-β-D-Glucan in Severe Dengue Infection Chancharoenthana, Wiwat Leelahavanichkul, Asada Ariyanon, Wassawon Vadcharavivad, Somratai Phatcharophaswattanakul, Suphasit Kamolratanakul, Supitcha Leaungwutiwong, Pornsawan Phumratanaprapin, Weerapong Wilairatana, Polrat Microorganisms Article The hallmark of severe dengue infection is the increased vascular permeability and hemodynamic alteration that might be associated with an intestinal permeability defect. However, the mechanisms underlying the gastrointestinal-related symptoms of dengue are not well characterized. A prospective observational study was conducted on patients with dengue who were categorized according to: (i) febrile versus critical phase and (ii) hospitalized patients with versus without the warning signs to evaluate the gut barrier using lactulose-to-mannitol excretion ratio (LEMR). Serum endotoxins, (1→3)-β-D-glucan (BG), and inflammatory parameters were measured. A total of 48 and 38 patients were enrolled in febrile illness and critical phase, respectively, while 22 and 64 patients presented with or without the warning signs, respectively. At enrollment, a positive LEMR test was found in 20 patients (91%) with warning signs, regardless of phase of infection. Likewise, serum endotoxins and BG, the indirect biomarkers for leaky gut, prominently increased in patients who developed severe dengue when compared with the non-severe dengue (endotoxins, 399.1 versus 143.4 pg/mL (p < 0.0001); BG, 123 versus 73.8 pg/mL (p = 0.016)). Modest impaired intestinal permeability occurred in dengue patients, particularly those with warning signs, and were associated with endotoxemia and elevated BG. Thus, leaky gut syndrome might be associated with severity of dengue infection. MDPI 2021-11-19 /pmc/articles/PMC8625530/ /pubmed/34835514 http://dx.doi.org/10.3390/microorganisms9112390 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chancharoenthana, Wiwat
Leelahavanichkul, Asada
Ariyanon, Wassawon
Vadcharavivad, Somratai
Phatcharophaswattanakul, Suphasit
Kamolratanakul, Supitcha
Leaungwutiwong, Pornsawan
Phumratanaprapin, Weerapong
Wilairatana, Polrat
Leaky Gut Syndrome Is Associated with Endotoxemia and Serum (1→3)-β-D-Glucan in Severe Dengue Infection
title Leaky Gut Syndrome Is Associated with Endotoxemia and Serum (1→3)-β-D-Glucan in Severe Dengue Infection
title_full Leaky Gut Syndrome Is Associated with Endotoxemia and Serum (1→3)-β-D-Glucan in Severe Dengue Infection
title_fullStr Leaky Gut Syndrome Is Associated with Endotoxemia and Serum (1→3)-β-D-Glucan in Severe Dengue Infection
title_full_unstemmed Leaky Gut Syndrome Is Associated with Endotoxemia and Serum (1→3)-β-D-Glucan in Severe Dengue Infection
title_short Leaky Gut Syndrome Is Associated with Endotoxemia and Serum (1→3)-β-D-Glucan in Severe Dengue Infection
title_sort leaky gut syndrome is associated with endotoxemia and serum (1→3)-β-d-glucan in severe dengue infection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8625530/
https://www.ncbi.nlm.nih.gov/pubmed/34835514
http://dx.doi.org/10.3390/microorganisms9112390
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