Genetic and Enzymatic Characteristics of CYP2A13 in Relation to Lung Damage

Cytochrome P450 2A13 is an omitted brother of CYP2A6 that has an important role in the drug metabolism of liver. Due to extrahepatic expression, it has gained less attention than CYP2A6, despite the fact that it plays a significant role in toxicant-induced pulmonary lesions and, therefore, lung canc...

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Autor principal: Vrzal, Radim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8625632/
https://www.ncbi.nlm.nih.gov/pubmed/34830188
http://dx.doi.org/10.3390/ijms222212306
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author Vrzal, Radim
author_facet Vrzal, Radim
author_sort Vrzal, Radim
collection PubMed
description Cytochrome P450 2A13 is an omitted brother of CYP2A6 that has an important role in the drug metabolism of liver. Due to extrahepatic expression, it has gained less attention than CYP2A6, despite the fact that it plays a significant role in toxicant-induced pulmonary lesions and, therefore, lung cancer. The purpose of this mini-review is to summarize the basic knowledge about this enzyme in relation to the substrates, inhibitors, genetic polymorphisms, and transcriptional regulation that are known so far (September 2021).
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spelling pubmed-86256322021-11-27 Genetic and Enzymatic Characteristics of CYP2A13 in Relation to Lung Damage Vrzal, Radim Int J Mol Sci Review Cytochrome P450 2A13 is an omitted brother of CYP2A6 that has an important role in the drug metabolism of liver. Due to extrahepatic expression, it has gained less attention than CYP2A6, despite the fact that it plays a significant role in toxicant-induced pulmonary lesions and, therefore, lung cancer. The purpose of this mini-review is to summarize the basic knowledge about this enzyme in relation to the substrates, inhibitors, genetic polymorphisms, and transcriptional regulation that are known so far (September 2021). MDPI 2021-11-14 /pmc/articles/PMC8625632/ /pubmed/34830188 http://dx.doi.org/10.3390/ijms222212306 Text en © 2021 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Vrzal, Radim
Genetic and Enzymatic Characteristics of CYP2A13 in Relation to Lung Damage
title Genetic and Enzymatic Characteristics of CYP2A13 in Relation to Lung Damage
title_full Genetic and Enzymatic Characteristics of CYP2A13 in Relation to Lung Damage
title_fullStr Genetic and Enzymatic Characteristics of CYP2A13 in Relation to Lung Damage
title_full_unstemmed Genetic and Enzymatic Characteristics of CYP2A13 in Relation to Lung Damage
title_short Genetic and Enzymatic Characteristics of CYP2A13 in Relation to Lung Damage
title_sort genetic and enzymatic characteristics of cyp2a13 in relation to lung damage
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8625632/
https://www.ncbi.nlm.nih.gov/pubmed/34830188
http://dx.doi.org/10.3390/ijms222212306
work_keys_str_mv AT vrzalradim geneticandenzymaticcharacteristicsofcyp2a13inrelationtolungdamage

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