Cargando…

Structural Biology of Nanobodies against the Spike Protein of SARS-CoV-2

Nanobodies are 130 amino acid single-domain antibodies (V(H)H) derived from the unique heavy-chain-only subclass of Camelid immunogloblins. Their small molecular size, facile expression, high affinity and stability have combined to make them unique targeting reagents with numerous applications in th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tang, Qilong, Owens, Raymond J., Naismith, James H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8625641/ https://www.ncbi.nlm.nih.gov/pubmed/34835020 http://dx.doi.org/10.3390/v13112214

Ejemplares similares

The use of nanobodies in a sensitive ELISA test for SARS-CoV-2 Spike 1 protein
por: Girt, Georgina C., et al.
Publicado: (2021)

Correlation between the binding affinity and the conformational entropy of nanobody SARS-CoV-2 spike protein complexes
por: Mikolajek, Halina, et al.
Publicado: (2022)

Screening, Expression, and Identification of Nanobody against SARS-CoV-2 Spike Protein
por: Su, Qianling, et al.
Publicado: (2022)

Author Correction: Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2
por: Huo, Jiangdong, et al.
Publicado: (2020)

Author Correction: Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2
por: Huo, Jiandong, et al.
Publicado: (2021)

Structural and Computational Studies of the SARS-CoV-2 Spike Protein Binding Mechanisms with Nanobodies: From Structure and Dynamics to Avidity-Driven Nanobody Engineering
por: Verkhivker, Gennady
Publicado: (2022)

An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike
por: Schoof, Michael, et al.
Publicado: (2020)

Prospects of Neutralizing Nanobodies Against SARS-CoV-2
por: Chen, Fangfang, et al.
Publicado: (2021)

Generation and Characterization of a Nanobody Against SARS-CoV
por: Li, Jiang-Fan, et al.
Publicado: (2021)

Nanobody repertoire generated against the spike protein of ancestral SARS-CoV-2 remains efficacious against the rapidly evolving virus
por: Ketaren, Natalia E., et al.
Publicado: (2023)

Development of multivalent nanobodies blocking SARS-CoV-2 infection by targeting RBD of spike protein
por: Lu, Qizhong, et al.
Publicado: (2021)

Structural basis of nanobodies neutralizing SARS-CoV-2 variants
por: Shi, Zhenzhong, et al.
Publicado: (2022)

An ultra-potent synthetic nanobody neutralizes SARS-CoV-2 by locking Spike into an inactive conformation
por: Schoof, Michael, et al.
Publicado: (2020)

Therapeutische Nanobodies gegen SARS-CoV-2
por: Güttler, Thomas, et al.
Publicado: (2022)

SARS-CoV-2 nanobodies 2.0
por: Labroussaa, Fabien, et al.
Publicado: (2021)

Nanobody-based label-free photoelectrochemical immunoassay for highly sensitive detection of SARS-CoV-2 spike protein
por: Chen, Yun, et al.
Publicado: (2022)

Isolation, characterization, and structure-based engineering of a neutralizing nanobody against SARS-CoV-2
por: Li, Tingting, et al.
Publicado: (2022)

Structural Characterization of a Neutralizing Nanobody With Broad Activity Against SARS-CoV-2 Variants
por: Li, Tingting, et al.
Publicado: (2022)

A bispecific monomeric nanobody induces spike trimer dimers and neutralizes SARS-CoV-2 in vivo
por: Hanke, Leo, et al.
Publicado: (2022)

A humanized nanobody phage display library yields potent binders of SARS CoV-2 spike
por: Fu, Ying, et al.
Publicado: (2022)

Preventing SARS-CoV-2 Infection Using Anti-spike Nanobody-IFN-β Conjugated Exosomes
por: Lyu, Xiabing, et al.
Publicado: (2022)

2636. Discovery of Spike Identification (SpiID) Nanobody Panel for SARS-CoV-2 Vaccine Development
por: Li, Qi, et al.
Publicado: (2023)

Structure of SARS-CoV-2 spike protein
por: Zhang, Jun, et al.
Publicado: (2021)

Emerging Landscape of Nanobodies and Their Neutralizing Applications against SARS-CoV-2 Virus
por: Feng, Xuemei, et al.
Publicado: (2023)

A Novel Fusion Protein System for the Production of Nanobodies and the SARS-CoV-2 Spike RBD in a Bacterial System
por: Nagy-Fazekas, Dóra, et al.
Publicado: (2023)

Nanobody Repertoires for Exposing Vulnerabilities of SARS-CoV-2
por: Mast, Fred D., et al.
Publicado: (2021)

Nanobody-Functionalized Cellulose for Capturing SARS-CoV-2
por: Sun, Xin, et al.
Publicado: (2022)

Potent Neutralization of SARS-CoV-2 by Hetero-Bivalent Alpaca Nanobodies Targeting the Spike Receptor-Binding Domain
por: Ma, Huan, et al.
Publicado: (2021)

A Potent Neutralizing Nanobody Targeting the Spike Receptor-Binding Domain of SARS-CoV-2 and the Structural Basis of Its Intimate Binding
por: Yang, Jing, et al.
Publicado: (2022)

A potent neutralizing nanobody against SARS‐CoV‐2 with inhaled delivery potential
por: Gai, Junwei, et al.
Publicado: (2021)

Dromedary camels as a natural source of neutralizing nanobodies against SARS-CoV-2
por: Chouchane, Lotfi, et al.
Publicado: (2021)

Allosteric Determinants of the SARS-CoV-2 Spike Protein Binding with Nanobodies: Examining Mechanisms of Mutational Escape and Sensitivity of the Omicron Variant
por: Verkhivker, Gennady
Publicado: (2022)

A panel of nanobodies recognizing conserved hidden clefts of all SARS-CoV-2 spike variants including Omicron
por: Maeda, Ryota, et al.
Publicado: (2022)

The Development of a Novel Nanobody Therapeutic for SARS-CoV-2
por: Ye, Gang, et al.
Publicado: (2020)

Camel nanobodies broadly neutralize SARS-CoV-2 variants
por: Hong, Jessica, et al.
Publicado: (2021)

Versatile and multivalent nanobodies efficiently neutralize SARS-CoV-2
por: Xiang, Yufei, et al.
Publicado: (2020)

Unlocking COVID therapeutic targets: A structure-based rationale against SARS-CoV-2, SARS-CoV and MERS-CoV Spike
por: Trigueiro-Louro, João, et al.
Publicado: (2020)

A cell-free nanobody engineering platform rapidly generates SARS-CoV-2 neutralizing nanobodies
por: Chen, Xun, et al.
Publicado: (2021)

Selection, biophysical and structural analysis of synthetic nanobodies that effectively neutralize SARS-CoV-2
por: Custódio, Tânia F., et al.
Publicado: (2020)

Nanobodies: Prospects of Expanding the Gamut of Neutralizing Antibodies Against the Novel Coronavirus, SARS-CoV-2
por: Konwarh, Rocktotpal
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_ujdn4qhkffrvqi9jbeigd72pj5