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Regulation of PXR Function by Coactivator and Corepressor Proteins: Ligand Binding Is Just the Beginning
The pregnane X receptor (PXR, NR1I2) is a nuclear receptor which exerts its regulatory function by heterodimerization with the retinoid-X-receptor α (RXRα, NR2B1) and binding to the promoter and enhancer regions of diverse target genes. PXR is involved in the regulation of drug metabolism and excret...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8625645/ https://www.ncbi.nlm.nih.gov/pubmed/34831358 http://dx.doi.org/10.3390/cells10113137 |