Delivery of pDNA to the Lung by Lipopolyplexes Using N-Lauroylsarcosine and Effect on the Pulmonary Fibrosis

In a previous study, we constructed a lung-targeting lipopolyplex containing polyethyleneimine (PEI), 1,2-di-O-octadecenyl-3-trimethylammonium propane (DOTMA), and N-lauroylsarcosine (LS). The lipopolyplex exhibited an extremely high gene expression in the lung after intravenous administration. Here...

Descripción completa

Detalles Bibliográficos
Autores principales: Kurosaki, Tomoaki, Kanda, Hiroki, Hashizume, Junya, Sato, Kayoko, Harasawa, Hitomi, Nakamura, Tadahiro, Sasaki, Hitoshi, Kodama, Yukinobu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8625672/
https://www.ncbi.nlm.nih.gov/pubmed/34834398
http://dx.doi.org/10.3390/pharmaceutics13111983

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8625672/
https://www.ncbi.nlm.nih.gov/pubmed/34834398
http://dx.doi.org/10.3390/pharmaceutics13111983

Ejemplares similares