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Delivery of pDNA to the Lung by Lipopolyplexes Using N-Lauroylsarcosine and Effect on the Pulmonary Fibrosis

In a previous study, we constructed a lung-targeting lipopolyplex containing polyethyleneimine (PEI), 1,2-di-O-octadecenyl-3-trimethylammonium propane (DOTMA), and N-lauroylsarcosine (LS). The lipopolyplex exhibited an extremely high gene expression in the lung after intravenous administration. Here...

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Detalles Bibliográficos
Autores principales:	Kurosaki, Tomoaki, Kanda, Hiroki, Hashizume, Junya, Sato, Kayoko, Harasawa, Hitomi, Nakamura, Tadahiro, Sasaki, Hitoshi, Kodama, Yukinobu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8625672/ https://www.ncbi.nlm.nih.gov/pubmed/34834398 http://dx.doi.org/10.3390/pharmaceutics13111983

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