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Identification of Hepatitis E Virus Genotypes 3 and 7 in Israel: A Public Health Concern?

Background: Hepatitis E (HEV) is an emerging cause of viral hepatitis worldwide. Swine carrying hepatitis E genotype 3 (HEV-3) are responsible for the majority of chronic viral hepatitis cases in developed countries. Recently, genotype 7 (HEV-7), isolated from a dromedary camel in the United Arab Em...

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Autores principales: Shirazi, Rachel, Pozzi, Paolo, Gozlan, Yael, Wax, Marina, Lustig, Yaniv, Linial, Michal, Mendelson, Ella, Bardenstein, Svetlana, Mor, Orna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8625709/
https://www.ncbi.nlm.nih.gov/pubmed/34835132
http://dx.doi.org/10.3390/v13112326
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author Shirazi, Rachel
Pozzi, Paolo
Gozlan, Yael
Wax, Marina
Lustig, Yaniv
Linial, Michal
Mendelson, Ella
Bardenstein, Svetlana
Mor, Orna
author_facet Shirazi, Rachel
Pozzi, Paolo
Gozlan, Yael
Wax, Marina
Lustig, Yaniv
Linial, Michal
Mendelson, Ella
Bardenstein, Svetlana
Mor, Orna
author_sort Shirazi, Rachel
collection PubMed
description Background: Hepatitis E (HEV) is an emerging cause of viral hepatitis worldwide. Swine carrying hepatitis E genotype 3 (HEV-3) are responsible for the majority of chronic viral hepatitis cases in developed countries. Recently, genotype 7 (HEV-7), isolated from a dromedary camel in the United Arab Emirates, was also associated with chronic viral hepatitis in a transplant recipient. In Israel, chronic HEV infection has not yet been reported, although HEV seroprevalence in humans is ~10%. Camels and swine are >65% seropositive. Here we report on the isolation and characterization of HEV from local camels and swine. Methods: Sera from camels (n = 142), feces from swine (n = 18) and blood from patients suspected of hepatitis E (n = 101) were collected during 2017–2020 and used to detect and characterize HEV sequences. Results: HEV-3 isolated from local swine and the camel-derived HEV-7 sequence were highly similar to HEV-3f and HEV-7 sequences (88.2% and 86.4%, respectively) related to viral hepatitis. The deduced amino acid sequences of both isolates were also highly conserved (>98%). Two patients were HEV-RNA positive; acute HEV-1 infection could be confirmed in one of them. Discussion: The absence of any reported HEV-3 and HEV-7 infection in humans remains puzzling, especially considering the reported seroprevalence rates, the similarity between HEV sequences related to chronic hepatitis and the HEV genotypes identified in swine and camels in Israel.
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spelling pubmed-86257092021-11-27 Identification of Hepatitis E Virus Genotypes 3 and 7 in Israel: A Public Health Concern? Shirazi, Rachel Pozzi, Paolo Gozlan, Yael Wax, Marina Lustig, Yaniv Linial, Michal Mendelson, Ella Bardenstein, Svetlana Mor, Orna Viruses Article Background: Hepatitis E (HEV) is an emerging cause of viral hepatitis worldwide. Swine carrying hepatitis E genotype 3 (HEV-3) are responsible for the majority of chronic viral hepatitis cases in developed countries. Recently, genotype 7 (HEV-7), isolated from a dromedary camel in the United Arab Emirates, was also associated with chronic viral hepatitis in a transplant recipient. In Israel, chronic HEV infection has not yet been reported, although HEV seroprevalence in humans is ~10%. Camels and swine are >65% seropositive. Here we report on the isolation and characterization of HEV from local camels and swine. Methods: Sera from camels (n = 142), feces from swine (n = 18) and blood from patients suspected of hepatitis E (n = 101) were collected during 2017–2020 and used to detect and characterize HEV sequences. Results: HEV-3 isolated from local swine and the camel-derived HEV-7 sequence were highly similar to HEV-3f and HEV-7 sequences (88.2% and 86.4%, respectively) related to viral hepatitis. The deduced amino acid sequences of both isolates were also highly conserved (>98%). Two patients were HEV-RNA positive; acute HEV-1 infection could be confirmed in one of them. Discussion: The absence of any reported HEV-3 and HEV-7 infection in humans remains puzzling, especially considering the reported seroprevalence rates, the similarity between HEV sequences related to chronic hepatitis and the HEV genotypes identified in swine and camels in Israel. MDPI 2021-11-22 /pmc/articles/PMC8625709/ /pubmed/34835132 http://dx.doi.org/10.3390/v13112326 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Shirazi, Rachel
Pozzi, Paolo
Gozlan, Yael
Wax, Marina
Lustig, Yaniv
Linial, Michal
Mendelson, Ella
Bardenstein, Svetlana
Mor, Orna
Identification of Hepatitis E Virus Genotypes 3 and 7 in Israel: A Public Health Concern?
title Identification of Hepatitis E Virus Genotypes 3 and 7 in Israel: A Public Health Concern?
title_full Identification of Hepatitis E Virus Genotypes 3 and 7 in Israel: A Public Health Concern?
title_fullStr Identification of Hepatitis E Virus Genotypes 3 and 7 in Israel: A Public Health Concern?
title_full_unstemmed Identification of Hepatitis E Virus Genotypes 3 and 7 in Israel: A Public Health Concern?
title_short Identification of Hepatitis E Virus Genotypes 3 and 7 in Israel: A Public Health Concern?
title_sort identification of hepatitis e virus genotypes 3 and 7 in israel: a public health concern?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8625709/
https://www.ncbi.nlm.nih.gov/pubmed/34835132
http://dx.doi.org/10.3390/v13112326
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