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A Simple Queuing Model for Molecular Communications Receivers

The complexity of molecular communications system, involving a massive number of interacting entities, makes scalability a fundamental property of simulators and modeling tools. A typical scenario is that of targeted drug delivery systems, which makes use of biological nanomachines close to a biolog...

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Detalles Bibliográficos
Autores principales: Femminella, Mauro, Reali, Gianluca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8625728/
https://www.ncbi.nlm.nih.gov/pubmed/34833758
http://dx.doi.org/10.3390/s21227664
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author Femminella, Mauro
Reali, Gianluca
author_facet Femminella, Mauro
Reali, Gianluca
author_sort Femminella, Mauro
collection PubMed
description The complexity of molecular communications system, involving a massive number of interacting entities, makes scalability a fundamental property of simulators and modeling tools. A typical scenario is that of targeted drug delivery systems, which makes use of biological nanomachines close to a biological target, able to release molecules in the diseased area. In this paper, we propose a simple but reliable receiver model for diffusion-based molecular communication systems tackling the time needed for analyzing such a system. The proposed model consists of using an equivalent markovian queuing model, which reproduces the aggregate behavior of thousands of receptors spread over the receiver surface. It takes into account not only the fact that the absorption of molecules can occur only through receptors, but also that absorption is not an instantaneous process and may require a significant time during which the receptor is not available to bind to other molecules. Our results, expressed in terms of number of absorbed molecules and average number of busy receptors, demonstrate that the proposed approach is in good agreement with results obtained through particle-based simulations of a large number of receptors, although the time taken for obtaining the results with the proposed model is an order of magnitudes lower than the simulation time. We believe that this model can be the precursor of novel class of models based on similar principles that allow realizing reliable simulations of much larger systems.
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spelling pubmed-86257282021-11-27 A Simple Queuing Model for Molecular Communications Receivers Femminella, Mauro Reali, Gianluca Sensors (Basel) Article The complexity of molecular communications system, involving a massive number of interacting entities, makes scalability a fundamental property of simulators and modeling tools. A typical scenario is that of targeted drug delivery systems, which makes use of biological nanomachines close to a biological target, able to release molecules in the diseased area. In this paper, we propose a simple but reliable receiver model for diffusion-based molecular communication systems tackling the time needed for analyzing such a system. The proposed model consists of using an equivalent markovian queuing model, which reproduces the aggregate behavior of thousands of receptors spread over the receiver surface. It takes into account not only the fact that the absorption of molecules can occur only through receptors, but also that absorption is not an instantaneous process and may require a significant time during which the receptor is not available to bind to other molecules. Our results, expressed in terms of number of absorbed molecules and average number of busy receptors, demonstrate that the proposed approach is in good agreement with results obtained through particle-based simulations of a large number of receptors, although the time taken for obtaining the results with the proposed model is an order of magnitudes lower than the simulation time. We believe that this model can be the precursor of novel class of models based on similar principles that allow realizing reliable simulations of much larger systems. MDPI 2021-11-18 /pmc/articles/PMC8625728/ /pubmed/34833758 http://dx.doi.org/10.3390/s21227664 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Femminella, Mauro
Reali, Gianluca
A Simple Queuing Model for Molecular Communications Receivers
title A Simple Queuing Model for Molecular Communications Receivers
title_full A Simple Queuing Model for Molecular Communications Receivers
title_fullStr A Simple Queuing Model for Molecular Communications Receivers
title_full_unstemmed A Simple Queuing Model for Molecular Communications Receivers
title_short A Simple Queuing Model for Molecular Communications Receivers
title_sort simple queuing model for molecular communications receivers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8625728/
https://www.ncbi.nlm.nih.gov/pubmed/34833758
http://dx.doi.org/10.3390/s21227664
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