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The Prognostic Value of Serum Soluble TREM-1 on Outcome in Adult Patients with Sepsis

Increased soluble triggering receptor expressed on myeloid cells 1 (sTREM-1) levels have been reported in patients with sepsis. We tested the hypotheses that serum sTREM-1 levels increase in the early phase of sepsis and decrease after sepsis under appropriate treatment and that sTREM-1 levels can p...

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Autores principales: Kung, Chia-Te, Su, Chih-Min, Hsiao, Sheng-Yuan, Chen, Fu-Cheng, Lai, Yun-Ru, Huang, Chih-Cheng, Lu, Cheng-Hsien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8625818/
https://www.ncbi.nlm.nih.gov/pubmed/34829326
http://dx.doi.org/10.3390/diagnostics11111979
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author Kung, Chia-Te
Su, Chih-Min
Hsiao, Sheng-Yuan
Chen, Fu-Cheng
Lai, Yun-Ru
Huang, Chih-Cheng
Lu, Cheng-Hsien
author_facet Kung, Chia-Te
Su, Chih-Min
Hsiao, Sheng-Yuan
Chen, Fu-Cheng
Lai, Yun-Ru
Huang, Chih-Cheng
Lu, Cheng-Hsien
author_sort Kung, Chia-Te
collection PubMed
description Increased soluble triggering receptor expressed on myeloid cells 1 (sTREM-1) levels have been reported in patients with sepsis. We tested the hypotheses that serum sTREM-1 levels increase in the early phase of sepsis and decrease after sepsis under appropriate treatment and that sTREM-1 levels can predict therapeutic outcomes. One hundred and fifty-five patients prospectively underwent blood samples including biochemical data, sTREM-1, and biomarkers on endothelial dysfunction as well as clinical severity index examinations. Blood samples from Days 1, 4, and 7 after admission were checked. For comparison, 50 healthy subjects were selected as healthy control. Those patients who had sepsis had significantly higher sTREM-1 levels than those of healthy control. sTREM-1 levels positively correlated with biomarkers for endothelial dysfunction (ICAM-1, VCAM-1, and E-selectin) and lactate level as well as clinical severity index (maximum 24 h APACHE score and Sequential Organ Failure Assessment (SOFA) score) upon admission. sTREM-1 concentrations were significantly higher from Day 1 to Day 7 in the non-survivors than in the survivors. A stepwise logistic regression analysis showed only sTREM-1 level and maximum 24 h SOFA score upon admission were significantly associated with fatality. Area under the receiver operating characteristic curve analysis for the diagnostic accuracy of sTREM-1 in sepsis-related fatality gave a value of 0.726, with a cutoff value of 384.6 pg/mL (sensitivity = 80.8% and specificity = 61.5%). sTREM-1 level may be valuable in auxiliary diagnosis, and it can serve as a useful biomarker as a screening service and follow-up therapeutic outcomes in sepsis.
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spelling pubmed-86258182021-11-27 The Prognostic Value of Serum Soluble TREM-1 on Outcome in Adult Patients with Sepsis Kung, Chia-Te Su, Chih-Min Hsiao, Sheng-Yuan Chen, Fu-Cheng Lai, Yun-Ru Huang, Chih-Cheng Lu, Cheng-Hsien Diagnostics (Basel) Article Increased soluble triggering receptor expressed on myeloid cells 1 (sTREM-1) levels have been reported in patients with sepsis. We tested the hypotheses that serum sTREM-1 levels increase in the early phase of sepsis and decrease after sepsis under appropriate treatment and that sTREM-1 levels can predict therapeutic outcomes. One hundred and fifty-five patients prospectively underwent blood samples including biochemical data, sTREM-1, and biomarkers on endothelial dysfunction as well as clinical severity index examinations. Blood samples from Days 1, 4, and 7 after admission were checked. For comparison, 50 healthy subjects were selected as healthy control. Those patients who had sepsis had significantly higher sTREM-1 levels than those of healthy control. sTREM-1 levels positively correlated with biomarkers for endothelial dysfunction (ICAM-1, VCAM-1, and E-selectin) and lactate level as well as clinical severity index (maximum 24 h APACHE score and Sequential Organ Failure Assessment (SOFA) score) upon admission. sTREM-1 concentrations were significantly higher from Day 1 to Day 7 in the non-survivors than in the survivors. A stepwise logistic regression analysis showed only sTREM-1 level and maximum 24 h SOFA score upon admission were significantly associated with fatality. Area under the receiver operating characteristic curve analysis for the diagnostic accuracy of sTREM-1 in sepsis-related fatality gave a value of 0.726, with a cutoff value of 384.6 pg/mL (sensitivity = 80.8% and specificity = 61.5%). sTREM-1 level may be valuable in auxiliary diagnosis, and it can serve as a useful biomarker as a screening service and follow-up therapeutic outcomes in sepsis. MDPI 2021-10-25 /pmc/articles/PMC8625818/ /pubmed/34829326 http://dx.doi.org/10.3390/diagnostics11111979 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kung, Chia-Te
Su, Chih-Min
Hsiao, Sheng-Yuan
Chen, Fu-Cheng
Lai, Yun-Ru
Huang, Chih-Cheng
Lu, Cheng-Hsien
The Prognostic Value of Serum Soluble TREM-1 on Outcome in Adult Patients with Sepsis
title The Prognostic Value of Serum Soluble TREM-1 on Outcome in Adult Patients with Sepsis
title_full The Prognostic Value of Serum Soluble TREM-1 on Outcome in Adult Patients with Sepsis
title_fullStr The Prognostic Value of Serum Soluble TREM-1 on Outcome in Adult Patients with Sepsis
title_full_unstemmed The Prognostic Value of Serum Soluble TREM-1 on Outcome in Adult Patients with Sepsis
title_short The Prognostic Value of Serum Soluble TREM-1 on Outcome in Adult Patients with Sepsis
title_sort prognostic value of serum soluble trem-1 on outcome in adult patients with sepsis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8625818/
https://www.ncbi.nlm.nih.gov/pubmed/34829326
http://dx.doi.org/10.3390/diagnostics11111979
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