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Deciphering the Genetic Architecture of Plant Virus Resistance by GWAS, State of the Art and Potential Advances

Growing virus resistant varieties is a highly effective means to avoid yield loss due to infection by many types of virus. The challenge is to be able to detect resistance donors within plant species diversity and then quickly introduce alleles conferring resistance into elite genetic backgrounds. U...

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Autores principales: Monnot, Severine, Desaint, Henri, Mary-Huard, Tristan, Moreau, Laurence, Schurdi-Levraud, Valerie, Boissot, Nathalie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8625838/
https://www.ncbi.nlm.nih.gov/pubmed/34831303
http://dx.doi.org/10.3390/cells10113080
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author Monnot, Severine
Desaint, Henri
Mary-Huard, Tristan
Moreau, Laurence
Schurdi-Levraud, Valerie
Boissot, Nathalie
author_facet Monnot, Severine
Desaint, Henri
Mary-Huard, Tristan
Moreau, Laurence
Schurdi-Levraud, Valerie
Boissot, Nathalie
author_sort Monnot, Severine
collection PubMed
description Growing virus resistant varieties is a highly effective means to avoid yield loss due to infection by many types of virus. The challenge is to be able to detect resistance donors within plant species diversity and then quickly introduce alleles conferring resistance into elite genetic backgrounds. Until now, mainly monogenic forms of resistance with major effects have been introduced in crops. Polygenic resistance is harder to map and introduce in susceptible genetic backgrounds, but it is likely more durable. Genome wide association studies (GWAS) offer an opportunity to accelerate mapping of both monogenic and polygenic resistance, but have seldom been implemented and described in the plant–virus interaction context. Yet, all of the 48 plant–virus GWAS published so far have successfully mapped QTLs involved in plant virus resistance. In this review, we analyzed general and specific GWAS issues regarding plant virus resistance. We have identified and described several key steps throughout the GWAS pipeline, from diversity panel assembly to GWAS result analyses. Based on the 48 published articles, we analyzed the impact of each key step on the GWAS power and showcase several GWAS methods tailored to all types of viruses.
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spelling pubmed-86258382021-11-27 Deciphering the Genetic Architecture of Plant Virus Resistance by GWAS, State of the Art and Potential Advances Monnot, Severine Desaint, Henri Mary-Huard, Tristan Moreau, Laurence Schurdi-Levraud, Valerie Boissot, Nathalie Cells Review Growing virus resistant varieties is a highly effective means to avoid yield loss due to infection by many types of virus. The challenge is to be able to detect resistance donors within plant species diversity and then quickly introduce alleles conferring resistance into elite genetic backgrounds. Until now, mainly monogenic forms of resistance with major effects have been introduced in crops. Polygenic resistance is harder to map and introduce in susceptible genetic backgrounds, but it is likely more durable. Genome wide association studies (GWAS) offer an opportunity to accelerate mapping of both monogenic and polygenic resistance, but have seldom been implemented and described in the plant–virus interaction context. Yet, all of the 48 plant–virus GWAS published so far have successfully mapped QTLs involved in plant virus resistance. In this review, we analyzed general and specific GWAS issues regarding plant virus resistance. We have identified and described several key steps throughout the GWAS pipeline, from diversity panel assembly to GWAS result analyses. Based on the 48 published articles, we analyzed the impact of each key step on the GWAS power and showcase several GWAS methods tailored to all types of viruses. MDPI 2021-11-08 /pmc/articles/PMC8625838/ /pubmed/34831303 http://dx.doi.org/10.3390/cells10113080 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Monnot, Severine
Desaint, Henri
Mary-Huard, Tristan
Moreau, Laurence
Schurdi-Levraud, Valerie
Boissot, Nathalie
Deciphering the Genetic Architecture of Plant Virus Resistance by GWAS, State of the Art and Potential Advances
title Deciphering the Genetic Architecture of Plant Virus Resistance by GWAS, State of the Art and Potential Advances
title_full Deciphering the Genetic Architecture of Plant Virus Resistance by GWAS, State of the Art and Potential Advances
title_fullStr Deciphering the Genetic Architecture of Plant Virus Resistance by GWAS, State of the Art and Potential Advances
title_full_unstemmed Deciphering the Genetic Architecture of Plant Virus Resistance by GWAS, State of the Art and Potential Advances
title_short Deciphering the Genetic Architecture of Plant Virus Resistance by GWAS, State of the Art and Potential Advances
title_sort deciphering the genetic architecture of plant virus resistance by gwas, state of the art and potential advances
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8625838/
https://www.ncbi.nlm.nih.gov/pubmed/34831303
http://dx.doi.org/10.3390/cells10113080
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