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Deciphering the Genetic Architecture of Plant Virus Resistance by GWAS, State of the Art and Potential Advances
Growing virus resistant varieties is a highly effective means to avoid yield loss due to infection by many types of virus. The challenge is to be able to detect resistance donors within plant species diversity and then quickly introduce alleles conferring resistance into elite genetic backgrounds. U...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8625838/ https://www.ncbi.nlm.nih.gov/pubmed/34831303 http://dx.doi.org/10.3390/cells10113080 |
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author | Monnot, Severine Desaint, Henri Mary-Huard, Tristan Moreau, Laurence Schurdi-Levraud, Valerie Boissot, Nathalie |
author_facet | Monnot, Severine Desaint, Henri Mary-Huard, Tristan Moreau, Laurence Schurdi-Levraud, Valerie Boissot, Nathalie |
author_sort | Monnot, Severine |
collection | PubMed |
description | Growing virus resistant varieties is a highly effective means to avoid yield loss due to infection by many types of virus. The challenge is to be able to detect resistance donors within plant species diversity and then quickly introduce alleles conferring resistance into elite genetic backgrounds. Until now, mainly monogenic forms of resistance with major effects have been introduced in crops. Polygenic resistance is harder to map and introduce in susceptible genetic backgrounds, but it is likely more durable. Genome wide association studies (GWAS) offer an opportunity to accelerate mapping of both monogenic and polygenic resistance, but have seldom been implemented and described in the plant–virus interaction context. Yet, all of the 48 plant–virus GWAS published so far have successfully mapped QTLs involved in plant virus resistance. In this review, we analyzed general and specific GWAS issues regarding plant virus resistance. We have identified and described several key steps throughout the GWAS pipeline, from diversity panel assembly to GWAS result analyses. Based on the 48 published articles, we analyzed the impact of each key step on the GWAS power and showcase several GWAS methods tailored to all types of viruses. |
format | Online Article Text |
id | pubmed-8625838 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86258382021-11-27 Deciphering the Genetic Architecture of Plant Virus Resistance by GWAS, State of the Art and Potential Advances Monnot, Severine Desaint, Henri Mary-Huard, Tristan Moreau, Laurence Schurdi-Levraud, Valerie Boissot, Nathalie Cells Review Growing virus resistant varieties is a highly effective means to avoid yield loss due to infection by many types of virus. The challenge is to be able to detect resistance donors within plant species diversity and then quickly introduce alleles conferring resistance into elite genetic backgrounds. Until now, mainly monogenic forms of resistance with major effects have been introduced in crops. Polygenic resistance is harder to map and introduce in susceptible genetic backgrounds, but it is likely more durable. Genome wide association studies (GWAS) offer an opportunity to accelerate mapping of both monogenic and polygenic resistance, but have seldom been implemented and described in the plant–virus interaction context. Yet, all of the 48 plant–virus GWAS published so far have successfully mapped QTLs involved in plant virus resistance. In this review, we analyzed general and specific GWAS issues regarding plant virus resistance. We have identified and described several key steps throughout the GWAS pipeline, from diversity panel assembly to GWAS result analyses. Based on the 48 published articles, we analyzed the impact of each key step on the GWAS power and showcase several GWAS methods tailored to all types of viruses. MDPI 2021-11-08 /pmc/articles/PMC8625838/ /pubmed/34831303 http://dx.doi.org/10.3390/cells10113080 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Monnot, Severine Desaint, Henri Mary-Huard, Tristan Moreau, Laurence Schurdi-Levraud, Valerie Boissot, Nathalie Deciphering the Genetic Architecture of Plant Virus Resistance by GWAS, State of the Art and Potential Advances |
title | Deciphering the Genetic Architecture of Plant Virus Resistance by GWAS, State of the Art and Potential Advances |
title_full | Deciphering the Genetic Architecture of Plant Virus Resistance by GWAS, State of the Art and Potential Advances |
title_fullStr | Deciphering the Genetic Architecture of Plant Virus Resistance by GWAS, State of the Art and Potential Advances |
title_full_unstemmed | Deciphering the Genetic Architecture of Plant Virus Resistance by GWAS, State of the Art and Potential Advances |
title_short | Deciphering the Genetic Architecture of Plant Virus Resistance by GWAS, State of the Art and Potential Advances |
title_sort | deciphering the genetic architecture of plant virus resistance by gwas, state of the art and potential advances |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8625838/ https://www.ncbi.nlm.nih.gov/pubmed/34831303 http://dx.doi.org/10.3390/cells10113080 |
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