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Association between Neighborhood Social Deprivation and Stage at Diagnosis among Breast Cancer Patients in South Carolina

The purpose of this study was to examine the association between neighborhood social deprivation and individual-level characteristics on breast cancer staging in African American and white breast cancer patients. We established a retrospective cohort of patients with breast cancer diagnosed from 199...

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Autores principales: Babatunde, Oluwole Adeyemi, Zahnd, Whitney E., Eberth, Jan M., Lawson, Andrew B., Adams, Swann Arp, Boakye, Eric Adjei, Jefferson, Melanie S., Allen, Caitlin G., Pearce, John L., Li, Hong, Halbert, Chanita Hughes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8625868/
https://www.ncbi.nlm.nih.gov/pubmed/34831579
http://dx.doi.org/10.3390/ijerph182211824
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author Babatunde, Oluwole Adeyemi
Zahnd, Whitney E.
Eberth, Jan M.
Lawson, Andrew B.
Adams, Swann Arp
Boakye, Eric Adjei
Jefferson, Melanie S.
Allen, Caitlin G.
Pearce, John L.
Li, Hong
Halbert, Chanita Hughes
author_facet Babatunde, Oluwole Adeyemi
Zahnd, Whitney E.
Eberth, Jan M.
Lawson, Andrew B.
Adams, Swann Arp
Boakye, Eric Adjei
Jefferson, Melanie S.
Allen, Caitlin G.
Pearce, John L.
Li, Hong
Halbert, Chanita Hughes
author_sort Babatunde, Oluwole Adeyemi
collection PubMed
description The purpose of this study was to examine the association between neighborhood social deprivation and individual-level characteristics on breast cancer staging in African American and white breast cancer patients. We established a retrospective cohort of patients with breast cancer diagnosed from 1996 to 2015 using the South Carolina Central Cancer Registry. We abstracted sociodemographic and clinical variables from the registry and linked these data to a county-level composite that captured neighborhood social conditions—the social deprivation index (SDI). Data were analyzed using chi-square tests, Student’s t-test, and multivariable ordinal regression analysis to evaluate associations. The study sample included 52,803 female patients with breast cancer. Results from the multivariable ordinal regression model demonstrate that higher SDI (OR = 1.06, 95% CI: 1.02–1.10), African American race (OR = 1.35, 95% CI: 1.29–1.41), and being unmarried (OR = 1.17, 95% CI: 1.13–1.22) were associated with a distant stage at diagnosis. Higher tumor grade, younger age, and more recent year of diagnosis were also associated with distant-stage diagnosis. As a proxy for neighborhood context, the SDI can be used by cancer registries and related population-based studies to identify geographic areas that could be prioritized for cancer prevention and control efforts.
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spelling pubmed-86258682021-11-27 Association between Neighborhood Social Deprivation and Stage at Diagnosis among Breast Cancer Patients in South Carolina Babatunde, Oluwole Adeyemi Zahnd, Whitney E. Eberth, Jan M. Lawson, Andrew B. Adams, Swann Arp Boakye, Eric Adjei Jefferson, Melanie S. Allen, Caitlin G. Pearce, John L. Li, Hong Halbert, Chanita Hughes Int J Environ Res Public Health Article The purpose of this study was to examine the association between neighborhood social deprivation and individual-level characteristics on breast cancer staging in African American and white breast cancer patients. We established a retrospective cohort of patients with breast cancer diagnosed from 1996 to 2015 using the South Carolina Central Cancer Registry. We abstracted sociodemographic and clinical variables from the registry and linked these data to a county-level composite that captured neighborhood social conditions—the social deprivation index (SDI). Data were analyzed using chi-square tests, Student’s t-test, and multivariable ordinal regression analysis to evaluate associations. The study sample included 52,803 female patients with breast cancer. Results from the multivariable ordinal regression model demonstrate that higher SDI (OR = 1.06, 95% CI: 1.02–1.10), African American race (OR = 1.35, 95% CI: 1.29–1.41), and being unmarried (OR = 1.17, 95% CI: 1.13–1.22) were associated with a distant stage at diagnosis. Higher tumor grade, younger age, and more recent year of diagnosis were also associated with distant-stage diagnosis. As a proxy for neighborhood context, the SDI can be used by cancer registries and related population-based studies to identify geographic areas that could be prioritized for cancer prevention and control efforts. MDPI 2021-11-11 /pmc/articles/PMC8625868/ /pubmed/34831579 http://dx.doi.org/10.3390/ijerph182211824 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Babatunde, Oluwole Adeyemi
Zahnd, Whitney E.
Eberth, Jan M.
Lawson, Andrew B.
Adams, Swann Arp
Boakye, Eric Adjei
Jefferson, Melanie S.
Allen, Caitlin G.
Pearce, John L.
Li, Hong
Halbert, Chanita Hughes
Association between Neighborhood Social Deprivation and Stage at Diagnosis among Breast Cancer Patients in South Carolina
title Association between Neighborhood Social Deprivation and Stage at Diagnosis among Breast Cancer Patients in South Carolina
title_full Association between Neighborhood Social Deprivation and Stage at Diagnosis among Breast Cancer Patients in South Carolina
title_fullStr Association between Neighborhood Social Deprivation and Stage at Diagnosis among Breast Cancer Patients in South Carolina
title_full_unstemmed Association between Neighborhood Social Deprivation and Stage at Diagnosis among Breast Cancer Patients in South Carolina
title_short Association between Neighborhood Social Deprivation and Stage at Diagnosis among Breast Cancer Patients in South Carolina
title_sort association between neighborhood social deprivation and stage at diagnosis among breast cancer patients in south carolina
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8625868/
https://www.ncbi.nlm.nih.gov/pubmed/34831579
http://dx.doi.org/10.3390/ijerph182211824
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