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NR3C1 Glucocorticoid Receptor Gene Polymorphisms Are Associated with Membranous and IgA Nephropathies

Glomerular diseases (GNs) are responsible for approximately 20% of chronic kidney diseases. Glucocorticoid receptor gene (NR3C1) single nucleotide polymorphisms (SNPs) are implicated in differences in predisposition to autoimmunity and steroid sensitivity. The aim of this study was to evaluate the f...

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Autores principales: Pac, Michał, Krata, Natalia, Moszczuk, Barbara, Wyczałkowska-Tomasik, Aleksandra, Kaleta, Beata, Foroncewicz, Bartosz, Rudnicki, Witold, Pączek, Leszek, Mucha, Krzysztof
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8625873/
https://www.ncbi.nlm.nih.gov/pubmed/34831409
http://dx.doi.org/10.3390/cells10113186
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author Pac, Michał
Krata, Natalia
Moszczuk, Barbara
Wyczałkowska-Tomasik, Aleksandra
Kaleta, Beata
Foroncewicz, Bartosz
Rudnicki, Witold
Pączek, Leszek
Mucha, Krzysztof
author_facet Pac, Michał
Krata, Natalia
Moszczuk, Barbara
Wyczałkowska-Tomasik, Aleksandra
Kaleta, Beata
Foroncewicz, Bartosz
Rudnicki, Witold
Pączek, Leszek
Mucha, Krzysztof
author_sort Pac, Michał
collection PubMed
description Glomerular diseases (GNs) are responsible for approximately 20% of chronic kidney diseases. Glucocorticoid receptor gene (NR3C1) single nucleotide polymorphisms (SNPs) are implicated in differences in predisposition to autoimmunity and steroid sensitivity. The aim of this study was to evaluate the frequency of the NR3C1 SNPs—rs6198, rs41423247 and rs17209237—in 72 IgA nephropathy (IgAN) and 38 membranous nephropathy (MN) patients compared to 175 healthy controls and to correlate the effectiveness of treatment in IgAN and MN groups defined as a reduction of proteinuria <1 g/24 h after 12 months of treatment. Real-time polymerase chain reactions and SNP array-based typing were used. We found significant rs41423247 association with MN (p = 0.026); a significant association of rs17209237 with eGFR reduction after follow-up period in all patients with GNs (p = 0.021) and with the degree of proteinuria after 1 year of therapy in all patients with a glomerulopathy (p = 0.013) and IgAN (p = 0.021); and in the same groups treated with steroids (p = 0.021; p = 0.012). We also observed the association between rs41423247 and IgAN histopathologic findings (p = 0.012). In conclusion, our results indicate that NR3C1 polymorphisms may influence treatment susceptibility and clinical outcome in IgAN and MN.
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spelling pubmed-86258732021-11-27 NR3C1 Glucocorticoid Receptor Gene Polymorphisms Are Associated with Membranous and IgA Nephropathies Pac, Michał Krata, Natalia Moszczuk, Barbara Wyczałkowska-Tomasik, Aleksandra Kaleta, Beata Foroncewicz, Bartosz Rudnicki, Witold Pączek, Leszek Mucha, Krzysztof Cells Article Glomerular diseases (GNs) are responsible for approximately 20% of chronic kidney diseases. Glucocorticoid receptor gene (NR3C1) single nucleotide polymorphisms (SNPs) are implicated in differences in predisposition to autoimmunity and steroid sensitivity. The aim of this study was to evaluate the frequency of the NR3C1 SNPs—rs6198, rs41423247 and rs17209237—in 72 IgA nephropathy (IgAN) and 38 membranous nephropathy (MN) patients compared to 175 healthy controls and to correlate the effectiveness of treatment in IgAN and MN groups defined as a reduction of proteinuria <1 g/24 h after 12 months of treatment. Real-time polymerase chain reactions and SNP array-based typing were used. We found significant rs41423247 association with MN (p = 0.026); a significant association of rs17209237 with eGFR reduction after follow-up period in all patients with GNs (p = 0.021) and with the degree of proteinuria after 1 year of therapy in all patients with a glomerulopathy (p = 0.013) and IgAN (p = 0.021); and in the same groups treated with steroids (p = 0.021; p = 0.012). We also observed the association between rs41423247 and IgAN histopathologic findings (p = 0.012). In conclusion, our results indicate that NR3C1 polymorphisms may influence treatment susceptibility and clinical outcome in IgAN and MN. MDPI 2021-11-16 /pmc/articles/PMC8625873/ /pubmed/34831409 http://dx.doi.org/10.3390/cells10113186 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pac, Michał
Krata, Natalia
Moszczuk, Barbara
Wyczałkowska-Tomasik, Aleksandra
Kaleta, Beata
Foroncewicz, Bartosz
Rudnicki, Witold
Pączek, Leszek
Mucha, Krzysztof
NR3C1 Glucocorticoid Receptor Gene Polymorphisms Are Associated with Membranous and IgA Nephropathies
title NR3C1 Glucocorticoid Receptor Gene Polymorphisms Are Associated with Membranous and IgA Nephropathies
title_full NR3C1 Glucocorticoid Receptor Gene Polymorphisms Are Associated with Membranous and IgA Nephropathies
title_fullStr NR3C1 Glucocorticoid Receptor Gene Polymorphisms Are Associated with Membranous and IgA Nephropathies
title_full_unstemmed NR3C1 Glucocorticoid Receptor Gene Polymorphisms Are Associated with Membranous and IgA Nephropathies
title_short NR3C1 Glucocorticoid Receptor Gene Polymorphisms Are Associated with Membranous and IgA Nephropathies
title_sort nr3c1 glucocorticoid receptor gene polymorphisms are associated with membranous and iga nephropathies
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8625873/
https://www.ncbi.nlm.nih.gov/pubmed/34831409
http://dx.doi.org/10.3390/cells10113186
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