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Reciprocal Regulation of Hippo and WBP2 Signalling—Implications in Cancer Therapy

Cancer is a global health problem. The delineation of molecular mechanisms pertinent to cancer initiation and development has spurred cancer therapy in the form of precision medicine. The Hippo signalling pathway is a tumour suppressor pathway implicated in a multitude of cancers. Elucidation of the...

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Autores principales: Lim, Yvonne Xinyi, Lin, Hexian, Seah, Sock Hong, Lim, Yoon Pin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8625973/
https://www.ncbi.nlm.nih.gov/pubmed/34831354
http://dx.doi.org/10.3390/cells10113130
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author Lim, Yvonne Xinyi
Lin, Hexian
Seah, Sock Hong
Lim, Yoon Pin
author_facet Lim, Yvonne Xinyi
Lin, Hexian
Seah, Sock Hong
Lim, Yoon Pin
author_sort Lim, Yvonne Xinyi
collection PubMed
description Cancer is a global health problem. The delineation of molecular mechanisms pertinent to cancer initiation and development has spurred cancer therapy in the form of precision medicine. The Hippo signalling pathway is a tumour suppressor pathway implicated in a multitude of cancers. Elucidation of the Hippo pathway has revealed an increasing number of regulators that are implicated, some being potential therapeutic targets for cancer interventions. WW domain-binding protein 2 (WBP2) is an oncogenic transcriptional co-factor that interacts, amongst others, with two other transcriptional co-activators, YAP and TAZ, in the Hippo pathway. WBP2 was recently discovered to modulate the upstream Hippo signalling components by associating with LATS2 and WWC3. Exacerbating the complexity of the WBP2/Hippo network, WBP2 itself is reciprocally regulated by Hippo-mediated microRNA biogenesis, contributing to a positive feedback loop that further drives carcinogenesis. Here, we summarise the biological mechanisms of WBP2/Hippo reciprocal regulation and propose therapeutic strategies to overcome Hippo defects in cancers through targeting WBP2.
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spelling pubmed-86259732021-11-27 Reciprocal Regulation of Hippo and WBP2 Signalling—Implications in Cancer Therapy Lim, Yvonne Xinyi Lin, Hexian Seah, Sock Hong Lim, Yoon Pin Cells Review Cancer is a global health problem. The delineation of molecular mechanisms pertinent to cancer initiation and development has spurred cancer therapy in the form of precision medicine. The Hippo signalling pathway is a tumour suppressor pathway implicated in a multitude of cancers. Elucidation of the Hippo pathway has revealed an increasing number of regulators that are implicated, some being potential therapeutic targets for cancer interventions. WW domain-binding protein 2 (WBP2) is an oncogenic transcriptional co-factor that interacts, amongst others, with two other transcriptional co-activators, YAP and TAZ, in the Hippo pathway. WBP2 was recently discovered to modulate the upstream Hippo signalling components by associating with LATS2 and WWC3. Exacerbating the complexity of the WBP2/Hippo network, WBP2 itself is reciprocally regulated by Hippo-mediated microRNA biogenesis, contributing to a positive feedback loop that further drives carcinogenesis. Here, we summarise the biological mechanisms of WBP2/Hippo reciprocal regulation and propose therapeutic strategies to overcome Hippo defects in cancers through targeting WBP2. MDPI 2021-11-11 /pmc/articles/PMC8625973/ /pubmed/34831354 http://dx.doi.org/10.3390/cells10113130 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lim, Yvonne Xinyi
Lin, Hexian
Seah, Sock Hong
Lim, Yoon Pin
Reciprocal Regulation of Hippo and WBP2 Signalling—Implications in Cancer Therapy
title Reciprocal Regulation of Hippo and WBP2 Signalling—Implications in Cancer Therapy
title_full Reciprocal Regulation of Hippo and WBP2 Signalling—Implications in Cancer Therapy
title_fullStr Reciprocal Regulation of Hippo and WBP2 Signalling—Implications in Cancer Therapy
title_full_unstemmed Reciprocal Regulation of Hippo and WBP2 Signalling—Implications in Cancer Therapy
title_short Reciprocal Regulation of Hippo and WBP2 Signalling—Implications in Cancer Therapy
title_sort reciprocal regulation of hippo and wbp2 signalling—implications in cancer therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8625973/
https://www.ncbi.nlm.nih.gov/pubmed/34831354
http://dx.doi.org/10.3390/cells10113130
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