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Reciprocal Regulation of Hippo and WBP2 Signalling—Implications in Cancer Therapy
Cancer is a global health problem. The delineation of molecular mechanisms pertinent to cancer initiation and development has spurred cancer therapy in the form of precision medicine. The Hippo signalling pathway is a tumour suppressor pathway implicated in a multitude of cancers. Elucidation of the...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8625973/ https://www.ncbi.nlm.nih.gov/pubmed/34831354 http://dx.doi.org/10.3390/cells10113130 |
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author | Lim, Yvonne Xinyi Lin, Hexian Seah, Sock Hong Lim, Yoon Pin |
author_facet | Lim, Yvonne Xinyi Lin, Hexian Seah, Sock Hong Lim, Yoon Pin |
author_sort | Lim, Yvonne Xinyi |
collection | PubMed |
description | Cancer is a global health problem. The delineation of molecular mechanisms pertinent to cancer initiation and development has spurred cancer therapy in the form of precision medicine. The Hippo signalling pathway is a tumour suppressor pathway implicated in a multitude of cancers. Elucidation of the Hippo pathway has revealed an increasing number of regulators that are implicated, some being potential therapeutic targets for cancer interventions. WW domain-binding protein 2 (WBP2) is an oncogenic transcriptional co-factor that interacts, amongst others, with two other transcriptional co-activators, YAP and TAZ, in the Hippo pathway. WBP2 was recently discovered to modulate the upstream Hippo signalling components by associating with LATS2 and WWC3. Exacerbating the complexity of the WBP2/Hippo network, WBP2 itself is reciprocally regulated by Hippo-mediated microRNA biogenesis, contributing to a positive feedback loop that further drives carcinogenesis. Here, we summarise the biological mechanisms of WBP2/Hippo reciprocal regulation and propose therapeutic strategies to overcome Hippo defects in cancers through targeting WBP2. |
format | Online Article Text |
id | pubmed-8625973 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86259732021-11-27 Reciprocal Regulation of Hippo and WBP2 Signalling—Implications in Cancer Therapy Lim, Yvonne Xinyi Lin, Hexian Seah, Sock Hong Lim, Yoon Pin Cells Review Cancer is a global health problem. The delineation of molecular mechanisms pertinent to cancer initiation and development has spurred cancer therapy in the form of precision medicine. The Hippo signalling pathway is a tumour suppressor pathway implicated in a multitude of cancers. Elucidation of the Hippo pathway has revealed an increasing number of regulators that are implicated, some being potential therapeutic targets for cancer interventions. WW domain-binding protein 2 (WBP2) is an oncogenic transcriptional co-factor that interacts, amongst others, with two other transcriptional co-activators, YAP and TAZ, in the Hippo pathway. WBP2 was recently discovered to modulate the upstream Hippo signalling components by associating with LATS2 and WWC3. Exacerbating the complexity of the WBP2/Hippo network, WBP2 itself is reciprocally regulated by Hippo-mediated microRNA biogenesis, contributing to a positive feedback loop that further drives carcinogenesis. Here, we summarise the biological mechanisms of WBP2/Hippo reciprocal regulation and propose therapeutic strategies to overcome Hippo defects in cancers through targeting WBP2. MDPI 2021-11-11 /pmc/articles/PMC8625973/ /pubmed/34831354 http://dx.doi.org/10.3390/cells10113130 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Lim, Yvonne Xinyi Lin, Hexian Seah, Sock Hong Lim, Yoon Pin Reciprocal Regulation of Hippo and WBP2 Signalling—Implications in Cancer Therapy |
title | Reciprocal Regulation of Hippo and WBP2 Signalling—Implications in Cancer Therapy |
title_full | Reciprocal Regulation of Hippo and WBP2 Signalling—Implications in Cancer Therapy |
title_fullStr | Reciprocal Regulation of Hippo and WBP2 Signalling—Implications in Cancer Therapy |
title_full_unstemmed | Reciprocal Regulation of Hippo and WBP2 Signalling—Implications in Cancer Therapy |
title_short | Reciprocal Regulation of Hippo and WBP2 Signalling—Implications in Cancer Therapy |
title_sort | reciprocal regulation of hippo and wbp2 signalling—implications in cancer therapy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8625973/ https://www.ncbi.nlm.nih.gov/pubmed/34831354 http://dx.doi.org/10.3390/cells10113130 |
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