Arginase 2 and Polyamines in Human Pancreatic Beta Cells: Possible Role in the Pathogenesis of Type 2 Diabetes

Arginase 2 (ARG2) is a manganese metalloenzyme involved in several tissue specific processes, from physiology to pathophysiology. It is variably expressed in extra-hepatic tissues and is located in the mitochondria. In human pancreatic beta cells, ARG2 is downregulated in type 2 diabetes. The enzyme...

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Autores principales: Marselli, Lorella, Bosi, Emanuele, De Luca, Carmela, Del Guerra, Silvia, Tesi, Marta, Suleiman, Mara, Marchetti, Piero
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8625980/
https://www.ncbi.nlm.nih.gov/pubmed/34829980
http://dx.doi.org/10.3390/ijms222212099
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author Marselli, Lorella
Bosi, Emanuele
De Luca, Carmela
Del Guerra, Silvia
Tesi, Marta
Suleiman, Mara
Marchetti, Piero
author_facet Marselli, Lorella
Bosi, Emanuele
De Luca, Carmela
Del Guerra, Silvia
Tesi, Marta
Suleiman, Mara
Marchetti, Piero
author_sort Marselli, Lorella
collection PubMed
description Arginase 2 (ARG2) is a manganese metalloenzyme involved in several tissue specific processes, from physiology to pathophysiology. It is variably expressed in extra-hepatic tissues and is located in the mitochondria. In human pancreatic beta cells, ARG2 is downregulated in type 2 diabetes. The enzyme regulates the synthesis of polyamines, that are involved in pancreas development and regulation of beta cell function. Here, we discuss several features of ARG2 and polyamines, which can be relevant to the pathophysiology of type 2 diabetes.
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spelling pubmed-86259802021-11-27 Arginase 2 and Polyamines in Human Pancreatic Beta Cells: Possible Role in the Pathogenesis of Type 2 Diabetes Marselli, Lorella Bosi, Emanuele De Luca, Carmela Del Guerra, Silvia Tesi, Marta Suleiman, Mara Marchetti, Piero Int J Mol Sci Review Arginase 2 (ARG2) is a manganese metalloenzyme involved in several tissue specific processes, from physiology to pathophysiology. It is variably expressed in extra-hepatic tissues and is located in the mitochondria. In human pancreatic beta cells, ARG2 is downregulated in type 2 diabetes. The enzyme regulates the synthesis of polyamines, that are involved in pancreas development and regulation of beta cell function. Here, we discuss several features of ARG2 and polyamines, which can be relevant to the pathophysiology of type 2 diabetes. MDPI 2021-11-09 /pmc/articles/PMC8625980/ /pubmed/34829980 http://dx.doi.org/10.3390/ijms222212099 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Marselli, Lorella
Bosi, Emanuele
De Luca, Carmela
Del Guerra, Silvia
Tesi, Marta
Suleiman, Mara
Marchetti, Piero
Arginase 2 and Polyamines in Human Pancreatic Beta Cells: Possible Role in the Pathogenesis of Type 2 Diabetes
title Arginase 2 and Polyamines in Human Pancreatic Beta Cells: Possible Role in the Pathogenesis of Type 2 Diabetes
title_full Arginase 2 and Polyamines in Human Pancreatic Beta Cells: Possible Role in the Pathogenesis of Type 2 Diabetes
title_fullStr Arginase 2 and Polyamines in Human Pancreatic Beta Cells: Possible Role in the Pathogenesis of Type 2 Diabetes
title_full_unstemmed Arginase 2 and Polyamines in Human Pancreatic Beta Cells: Possible Role in the Pathogenesis of Type 2 Diabetes
title_short Arginase 2 and Polyamines in Human Pancreatic Beta Cells: Possible Role in the Pathogenesis of Type 2 Diabetes
title_sort arginase 2 and polyamines in human pancreatic beta cells: possible role in the pathogenesis of type 2 diabetes
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8625980/
https://www.ncbi.nlm.nih.gov/pubmed/34829980
http://dx.doi.org/10.3390/ijms222212099
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