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Carbapenemase-Producing Klebsiella pneumoniae Colonization and Infection in Solid Organ Transplant Recipients: A Single-Center, Retrospective Study

Carbapenemase-KPC producing Klebsiella pneumoniae (CP-Kp) infection represents a serious threat to solid organ transplant (SOT). All patients admitted between 1 May 2011 and 31 August 2014 undergoing SOT were included in the retrospective study. The primary outcomes included a description of the ass...

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Autores principales: Pagani, Nicole, Corcione, Silvia, Lupia, Tommaso, Scabini, Silvia, Filippini, Claudia, Angilletta, Roberto, Shbaklo, Nour, Mornese Pinna, Simone, Romagnoli, Renato, Biancone, Luigi, Cavallo, Rossana, Di Perri, Giovanni, Solidoro, Paolo, Boffini, Massimo, De Rosa, Francesco Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8626028/
https://www.ncbi.nlm.nih.gov/pubmed/34835398
http://dx.doi.org/10.3390/microorganisms9112272
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author Pagani, Nicole
Corcione, Silvia
Lupia, Tommaso
Scabini, Silvia
Filippini, Claudia
Angilletta, Roberto
Shbaklo, Nour
Mornese Pinna, Simone
Romagnoli, Renato
Biancone, Luigi
Cavallo, Rossana
Di Perri, Giovanni
Solidoro, Paolo
Boffini, Massimo
De Rosa, Francesco Giuseppe
author_facet Pagani, Nicole
Corcione, Silvia
Lupia, Tommaso
Scabini, Silvia
Filippini, Claudia
Angilletta, Roberto
Shbaklo, Nour
Mornese Pinna, Simone
Romagnoli, Renato
Biancone, Luigi
Cavallo, Rossana
Di Perri, Giovanni
Solidoro, Paolo
Boffini, Massimo
De Rosa, Francesco Giuseppe
author_sort Pagani, Nicole
collection PubMed
description Carbapenemase-KPC producing Klebsiella pneumoniae (CP-Kp) infection represents a serious threat to solid organ transplant (SOT). All patients admitted between 1 May 2011 and 31 August 2014 undergoing SOT were included in the retrospective study. The primary outcomes included a description of the association of enteric colonization and invasive infections by CP-Kp with one-year mortality. Secondary outcomes were the study of risk factors for colonization and invasive infections by CP-Kp. Results: A total of 5.4% (45/828) of SOT recipients had at least one positive rectal swab for CP-Kp, with most (88.9%) occurring after transplantation. 4.5% (35/828) of patients developed a CP-Kp-related invasive infection, with 68.6% (24/35) being previously colonized. The 1-year mortality was 31.1% in patients with enteric colonization with CP-Kp and, it was 51.4% among patients with CP-Kp-related invasive infections. At univariate analysis, colonization, invasive infections, sepsis, severe sepsis, and septic shock were significantly associated with 1-year mortality. At multivariate analysis, only invasive infections and the combination of sepsis, severe sepsis, or septic shock were significantly associated with 1-year mortality, whereas gastrointestinal colonization was significantly associated with survival. In this population, the 1-year mortality was significantly associated with invasive infections; otherwise, gastrointestinal colonization was not associated with increased 1-year mortality.
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spelling pubmed-86260282021-11-27 Carbapenemase-Producing Klebsiella pneumoniae Colonization and Infection in Solid Organ Transplant Recipients: A Single-Center, Retrospective Study Pagani, Nicole Corcione, Silvia Lupia, Tommaso Scabini, Silvia Filippini, Claudia Angilletta, Roberto Shbaklo, Nour Mornese Pinna, Simone Romagnoli, Renato Biancone, Luigi Cavallo, Rossana Di Perri, Giovanni Solidoro, Paolo Boffini, Massimo De Rosa, Francesco Giuseppe Microorganisms Article Carbapenemase-KPC producing Klebsiella pneumoniae (CP-Kp) infection represents a serious threat to solid organ transplant (SOT). All patients admitted between 1 May 2011 and 31 August 2014 undergoing SOT were included in the retrospective study. The primary outcomes included a description of the association of enteric colonization and invasive infections by CP-Kp with one-year mortality. Secondary outcomes were the study of risk factors for colonization and invasive infections by CP-Kp. Results: A total of 5.4% (45/828) of SOT recipients had at least one positive rectal swab for CP-Kp, with most (88.9%) occurring after transplantation. 4.5% (35/828) of patients developed a CP-Kp-related invasive infection, with 68.6% (24/35) being previously colonized. The 1-year mortality was 31.1% in patients with enteric colonization with CP-Kp and, it was 51.4% among patients with CP-Kp-related invasive infections. At univariate analysis, colonization, invasive infections, sepsis, severe sepsis, and septic shock were significantly associated with 1-year mortality. At multivariate analysis, only invasive infections and the combination of sepsis, severe sepsis, or septic shock were significantly associated with 1-year mortality, whereas gastrointestinal colonization was significantly associated with survival. In this population, the 1-year mortality was significantly associated with invasive infections; otherwise, gastrointestinal colonization was not associated with increased 1-year mortality. MDPI 2021-10-31 /pmc/articles/PMC8626028/ /pubmed/34835398 http://dx.doi.org/10.3390/microorganisms9112272 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pagani, Nicole
Corcione, Silvia
Lupia, Tommaso
Scabini, Silvia
Filippini, Claudia
Angilletta, Roberto
Shbaklo, Nour
Mornese Pinna, Simone
Romagnoli, Renato
Biancone, Luigi
Cavallo, Rossana
Di Perri, Giovanni
Solidoro, Paolo
Boffini, Massimo
De Rosa, Francesco Giuseppe
Carbapenemase-Producing Klebsiella pneumoniae Colonization and Infection in Solid Organ Transplant Recipients: A Single-Center, Retrospective Study
title Carbapenemase-Producing Klebsiella pneumoniae Colonization and Infection in Solid Organ Transplant Recipients: A Single-Center, Retrospective Study
title_full Carbapenemase-Producing Klebsiella pneumoniae Colonization and Infection in Solid Organ Transplant Recipients: A Single-Center, Retrospective Study
title_fullStr Carbapenemase-Producing Klebsiella pneumoniae Colonization and Infection in Solid Organ Transplant Recipients: A Single-Center, Retrospective Study
title_full_unstemmed Carbapenemase-Producing Klebsiella pneumoniae Colonization and Infection in Solid Organ Transplant Recipients: A Single-Center, Retrospective Study
title_short Carbapenemase-Producing Klebsiella pneumoniae Colonization and Infection in Solid Organ Transplant Recipients: A Single-Center, Retrospective Study
title_sort carbapenemase-producing klebsiella pneumoniae colonization and infection in solid organ transplant recipients: a single-center, retrospective study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8626028/
https://www.ncbi.nlm.nih.gov/pubmed/34835398
http://dx.doi.org/10.3390/microorganisms9112272
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