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Carbapenemase-Producing Klebsiella pneumoniae Colonization and Infection in Solid Organ Transplant Recipients: A Single-Center, Retrospective Study
Carbapenemase-KPC producing Klebsiella pneumoniae (CP-Kp) infection represents a serious threat to solid organ transplant (SOT). All patients admitted between 1 May 2011 and 31 August 2014 undergoing SOT were included in the retrospective study. The primary outcomes included a description of the ass...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8626028/ https://www.ncbi.nlm.nih.gov/pubmed/34835398 http://dx.doi.org/10.3390/microorganisms9112272 |
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author | Pagani, Nicole Corcione, Silvia Lupia, Tommaso Scabini, Silvia Filippini, Claudia Angilletta, Roberto Shbaklo, Nour Mornese Pinna, Simone Romagnoli, Renato Biancone, Luigi Cavallo, Rossana Di Perri, Giovanni Solidoro, Paolo Boffini, Massimo De Rosa, Francesco Giuseppe |
author_facet | Pagani, Nicole Corcione, Silvia Lupia, Tommaso Scabini, Silvia Filippini, Claudia Angilletta, Roberto Shbaklo, Nour Mornese Pinna, Simone Romagnoli, Renato Biancone, Luigi Cavallo, Rossana Di Perri, Giovanni Solidoro, Paolo Boffini, Massimo De Rosa, Francesco Giuseppe |
author_sort | Pagani, Nicole |
collection | PubMed |
description | Carbapenemase-KPC producing Klebsiella pneumoniae (CP-Kp) infection represents a serious threat to solid organ transplant (SOT). All patients admitted between 1 May 2011 and 31 August 2014 undergoing SOT were included in the retrospective study. The primary outcomes included a description of the association of enteric colonization and invasive infections by CP-Kp with one-year mortality. Secondary outcomes were the study of risk factors for colonization and invasive infections by CP-Kp. Results: A total of 5.4% (45/828) of SOT recipients had at least one positive rectal swab for CP-Kp, with most (88.9%) occurring after transplantation. 4.5% (35/828) of patients developed a CP-Kp-related invasive infection, with 68.6% (24/35) being previously colonized. The 1-year mortality was 31.1% in patients with enteric colonization with CP-Kp and, it was 51.4% among patients with CP-Kp-related invasive infections. At univariate analysis, colonization, invasive infections, sepsis, severe sepsis, and septic shock were significantly associated with 1-year mortality. At multivariate analysis, only invasive infections and the combination of sepsis, severe sepsis, or septic shock were significantly associated with 1-year mortality, whereas gastrointestinal colonization was significantly associated with survival. In this population, the 1-year mortality was significantly associated with invasive infections; otherwise, gastrointestinal colonization was not associated with increased 1-year mortality. |
format | Online Article Text |
id | pubmed-8626028 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86260282021-11-27 Carbapenemase-Producing Klebsiella pneumoniae Colonization and Infection in Solid Organ Transplant Recipients: A Single-Center, Retrospective Study Pagani, Nicole Corcione, Silvia Lupia, Tommaso Scabini, Silvia Filippini, Claudia Angilletta, Roberto Shbaklo, Nour Mornese Pinna, Simone Romagnoli, Renato Biancone, Luigi Cavallo, Rossana Di Perri, Giovanni Solidoro, Paolo Boffini, Massimo De Rosa, Francesco Giuseppe Microorganisms Article Carbapenemase-KPC producing Klebsiella pneumoniae (CP-Kp) infection represents a serious threat to solid organ transplant (SOT). All patients admitted between 1 May 2011 and 31 August 2014 undergoing SOT were included in the retrospective study. The primary outcomes included a description of the association of enteric colonization and invasive infections by CP-Kp with one-year mortality. Secondary outcomes were the study of risk factors for colonization and invasive infections by CP-Kp. Results: A total of 5.4% (45/828) of SOT recipients had at least one positive rectal swab for CP-Kp, with most (88.9%) occurring after transplantation. 4.5% (35/828) of patients developed a CP-Kp-related invasive infection, with 68.6% (24/35) being previously colonized. The 1-year mortality was 31.1% in patients with enteric colonization with CP-Kp and, it was 51.4% among patients with CP-Kp-related invasive infections. At univariate analysis, colonization, invasive infections, sepsis, severe sepsis, and septic shock were significantly associated with 1-year mortality. At multivariate analysis, only invasive infections and the combination of sepsis, severe sepsis, or septic shock were significantly associated with 1-year mortality, whereas gastrointestinal colonization was significantly associated with survival. In this population, the 1-year mortality was significantly associated with invasive infections; otherwise, gastrointestinal colonization was not associated with increased 1-year mortality. MDPI 2021-10-31 /pmc/articles/PMC8626028/ /pubmed/34835398 http://dx.doi.org/10.3390/microorganisms9112272 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Pagani, Nicole Corcione, Silvia Lupia, Tommaso Scabini, Silvia Filippini, Claudia Angilletta, Roberto Shbaklo, Nour Mornese Pinna, Simone Romagnoli, Renato Biancone, Luigi Cavallo, Rossana Di Perri, Giovanni Solidoro, Paolo Boffini, Massimo De Rosa, Francesco Giuseppe Carbapenemase-Producing Klebsiella pneumoniae Colonization and Infection in Solid Organ Transplant Recipients: A Single-Center, Retrospective Study |
title | Carbapenemase-Producing Klebsiella pneumoniae Colonization and Infection in Solid Organ Transplant Recipients: A Single-Center, Retrospective Study |
title_full | Carbapenemase-Producing Klebsiella pneumoniae Colonization and Infection in Solid Organ Transplant Recipients: A Single-Center, Retrospective Study |
title_fullStr | Carbapenemase-Producing Klebsiella pneumoniae Colonization and Infection in Solid Organ Transplant Recipients: A Single-Center, Retrospective Study |
title_full_unstemmed | Carbapenemase-Producing Klebsiella pneumoniae Colonization and Infection in Solid Organ Transplant Recipients: A Single-Center, Retrospective Study |
title_short | Carbapenemase-Producing Klebsiella pneumoniae Colonization and Infection in Solid Organ Transplant Recipients: A Single-Center, Retrospective Study |
title_sort | carbapenemase-producing klebsiella pneumoniae colonization and infection in solid organ transplant recipients: a single-center, retrospective study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8626028/ https://www.ncbi.nlm.nih.gov/pubmed/34835398 http://dx.doi.org/10.3390/microorganisms9112272 |
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