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Structural basis for sarcolipin’s regulation of muscle thermogenesis by the sarcoplasmic reticulum Ca(2+)-ATPase

The sarcoplasmic reticulum (SR) Ca(2+)-ATPase (SERCA) plays a central role in muscle contractility and nonshivering thermogenesis. SERCA is regulated by sarcolipin (SLN), a single-pass membrane protein that uncouples Ca(2+) transport from ATP hydrolysis, promoting futile enzymatic cycles and heat ge...

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Detalles Bibliográficos
Autores principales:	Wang, Songlin, Gopinath, Tata, Larsen, Erik K., Weber, Daniel K., Walker, Caitlin, Uddigiri, Venkateswara Reddy, Mote, Kaustubh R., Sahoo, Sanjaya K., Periasamy, Muthu, Veglia, Gianluigi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2021
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8626070/ https://www.ncbi.nlm.nih.gov/pubmed/34826239 http://dx.doi.org/10.1126/sciadv.abi7154

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