Amilorides inhibit SARS-CoV-2 replication in vitro by targeting RNA structures

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The SARS-CoV-2 pandemic, and the likelihood of future coronavirus pandemics, emphasized the urgent need for development of novel antivirals. Small-molecule chemical probes offer both to reveal aspects of virus replication and to serve as leads for antiviral therapeutic development. Here, we report o...

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Detalles Bibliográficos
Autores principales: Zafferani, Martina, Haddad, Christina, Luo, Le, Davila-Calderon, Jesse, Chiu, Liang-Yuan, Mugisha, Christian Shema, Monaghan, Adeline G., Kennedy, Andrew A., Yesselman, Joseph D., Gifford, Robert J., Tai, Andrew W., Kutluay, Sebla B., Li, Mei-Ling, Brewer, Gary, Tolbert, Blanton S., Hargrove, Amanda E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8626076/
https://www.ncbi.nlm.nih.gov/pubmed/34826236
http://dx.doi.org/10.1126/sciadv.abl6096
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