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Implantable system for chronotherapy
Diurnal variation in enzymes, hormones, and other biological mediators has long been recognized in mammalian physiology. Developments in pharmacobiology over the past few decades have shown that timing drug delivery can enhance drug efficacy. Here, we report the development of a battery-free, refill...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8626078/ https://www.ncbi.nlm.nih.gov/pubmed/34826238 http://dx.doi.org/10.1126/sciadv.abj4624 |
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author | Lee, Seung Ho Wan, Qianqian Wentworth, Adam Ballinger, Ian Ishida, Keiko Collins, Joy E. Tamang, Siddartha Huang, Hen-Wei Li, Canchen Hess, Kaitlyn Lopes, Aaron Kirtane, Ameya R. Lee, Jung Seung Lee, SeJun Chen, Wei Wong, Kaitlyn Selsing, George Kim, Hyunjoon Buckley, Stephen T. Hayward, Alison Langer, Robert Traverso, Giovanni |
author_facet | Lee, Seung Ho Wan, Qianqian Wentworth, Adam Ballinger, Ian Ishida, Keiko Collins, Joy E. Tamang, Siddartha Huang, Hen-Wei Li, Canchen Hess, Kaitlyn Lopes, Aaron Kirtane, Ameya R. Lee, Jung Seung Lee, SeJun Chen, Wei Wong, Kaitlyn Selsing, George Kim, Hyunjoon Buckley, Stephen T. Hayward, Alison Langer, Robert Traverso, Giovanni |
author_sort | Lee, Seung Ho |
collection | PubMed |
description | Diurnal variation in enzymes, hormones, and other biological mediators has long been recognized in mammalian physiology. Developments in pharmacobiology over the past few decades have shown that timing drug delivery can enhance drug efficacy. Here, we report the development of a battery-free, refillable, subcutaneous, and trocar-compatible implantable system that facilitates chronotherapy by enabling tight control over the timing of drug administration in response to external mechanical actuation. The external wearable system is coupled to a mobile app to facilitate control over dosing time. Using this system, we show the efficacy of bromocriptine on glycemic control in a diabetic rat model. We also demonstrate that antihypertensives can be delivered through this device, which could have clinical applications given the recognized diurnal variation of hypertension-related complications. We anticipate that implants capable of chronotherapy will have a substantial impact on our capacity to enhance treatment effectiveness for a broad range of chronic conditions. |
format | Online Article Text |
id | pubmed-8626078 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | American Association for the Advancement of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-86260782021-12-06 Implantable system for chronotherapy Lee, Seung Ho Wan, Qianqian Wentworth, Adam Ballinger, Ian Ishida, Keiko Collins, Joy E. Tamang, Siddartha Huang, Hen-Wei Li, Canchen Hess, Kaitlyn Lopes, Aaron Kirtane, Ameya R. Lee, Jung Seung Lee, SeJun Chen, Wei Wong, Kaitlyn Selsing, George Kim, Hyunjoon Buckley, Stephen T. Hayward, Alison Langer, Robert Traverso, Giovanni Sci Adv Physical and Materials Sciences Diurnal variation in enzymes, hormones, and other biological mediators has long been recognized in mammalian physiology. Developments in pharmacobiology over the past few decades have shown that timing drug delivery can enhance drug efficacy. Here, we report the development of a battery-free, refillable, subcutaneous, and trocar-compatible implantable system that facilitates chronotherapy by enabling tight control over the timing of drug administration in response to external mechanical actuation. The external wearable system is coupled to a mobile app to facilitate control over dosing time. Using this system, we show the efficacy of bromocriptine on glycemic control in a diabetic rat model. We also demonstrate that antihypertensives can be delivered through this device, which could have clinical applications given the recognized diurnal variation of hypertension-related complications. We anticipate that implants capable of chronotherapy will have a substantial impact on our capacity to enhance treatment effectiveness for a broad range of chronic conditions. American Association for the Advancement of Science 2021-11-26 /pmc/articles/PMC8626078/ /pubmed/34826238 http://dx.doi.org/10.1126/sciadv.abj4624 Text en Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY). https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution license (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Physical and Materials Sciences Lee, Seung Ho Wan, Qianqian Wentworth, Adam Ballinger, Ian Ishida, Keiko Collins, Joy E. Tamang, Siddartha Huang, Hen-Wei Li, Canchen Hess, Kaitlyn Lopes, Aaron Kirtane, Ameya R. Lee, Jung Seung Lee, SeJun Chen, Wei Wong, Kaitlyn Selsing, George Kim, Hyunjoon Buckley, Stephen T. Hayward, Alison Langer, Robert Traverso, Giovanni Implantable system for chronotherapy |
title | Implantable system for chronotherapy |
title_full | Implantable system for chronotherapy |
title_fullStr | Implantable system for chronotherapy |
title_full_unstemmed | Implantable system for chronotherapy |
title_short | Implantable system for chronotherapy |
title_sort | implantable system for chronotherapy |
topic | Physical and Materials Sciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8626078/ https://www.ncbi.nlm.nih.gov/pubmed/34826238 http://dx.doi.org/10.1126/sciadv.abj4624 |
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