SARS-CoV-2 Spike Protein in Intestinal Cells of a Patient with Coronavirus Disease 2019 Multisystem Inflammatory Syndrome

A previously healthy 12-year-old boy had severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-related multisystem inflammatory syndrome (MIS-C) that was rapidly fatal. Autopsy revealed the presence of a large intracardiac thrombus. SARS-CoV-2 spike protein was detected in intestinal cells, s...

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Autores principales: Mayordomo-Colunga, Juan, Vivanco-Allende, Ana, López-Alonso, Inés, López-Martínez, Cecilia, Fernández-Vega, Iván, Gil-Peña, Helena, Rey, Corsino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8626144/
https://www.ncbi.nlm.nih.gov/pubmed/34843710
http://dx.doi.org/10.1016/j.jpeds.2021.11.058
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author Mayordomo-Colunga, Juan
Vivanco-Allende, Ana
López-Alonso, Inés
López-Martínez, Cecilia
Fernández-Vega, Iván
Gil-Peña, Helena
Rey, Corsino
author_facet Mayordomo-Colunga, Juan
Vivanco-Allende, Ana
López-Alonso, Inés
López-Martínez, Cecilia
Fernández-Vega, Iván
Gil-Peña, Helena
Rey, Corsino
author_sort Mayordomo-Colunga, Juan
collection PubMed
description A previously healthy 12-year-old boy had severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-related multisystem inflammatory syndrome (MIS-C) that was rapidly fatal. Autopsy revealed the presence of a large intracardiac thrombus. SARS-CoV-2 spike protein was detected in intestinal cells, supporting the hypothesis that viral presence in the gut may be related to the immunologic response of MIS-C.
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spelling pubmed-86261442021-11-29 SARS-CoV-2 Spike Protein in Intestinal Cells of a Patient with Coronavirus Disease 2019 Multisystem Inflammatory Syndrome Mayordomo-Colunga, Juan Vivanco-Allende, Ana López-Alonso, Inés López-Martínez, Cecilia Fernández-Vega, Iván Gil-Peña, Helena Rey, Corsino J Pediatr Brief Report A previously healthy 12-year-old boy had severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-related multisystem inflammatory syndrome (MIS-C) that was rapidly fatal. Autopsy revealed the presence of a large intracardiac thrombus. SARS-CoV-2 spike protein was detected in intestinal cells, supporting the hypothesis that viral presence in the gut may be related to the immunologic response of MIS-C. Elsevier Inc. 2022-04 2021-11-27 /pmc/articles/PMC8626144/ /pubmed/34843710 http://dx.doi.org/10.1016/j.jpeds.2021.11.058 Text en © 2021 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Brief Report
Mayordomo-Colunga, Juan
Vivanco-Allende, Ana
López-Alonso, Inés
López-Martínez, Cecilia
Fernández-Vega, Iván
Gil-Peña, Helena
Rey, Corsino
SARS-CoV-2 Spike Protein in Intestinal Cells of a Patient with Coronavirus Disease 2019 Multisystem Inflammatory Syndrome
title SARS-CoV-2 Spike Protein in Intestinal Cells of a Patient with Coronavirus Disease 2019 Multisystem Inflammatory Syndrome
title_full SARS-CoV-2 Spike Protein in Intestinal Cells of a Patient with Coronavirus Disease 2019 Multisystem Inflammatory Syndrome
title_fullStr SARS-CoV-2 Spike Protein in Intestinal Cells of a Patient with Coronavirus Disease 2019 Multisystem Inflammatory Syndrome
title_full_unstemmed SARS-CoV-2 Spike Protein in Intestinal Cells of a Patient with Coronavirus Disease 2019 Multisystem Inflammatory Syndrome
title_short SARS-CoV-2 Spike Protein in Intestinal Cells of a Patient with Coronavirus Disease 2019 Multisystem Inflammatory Syndrome
title_sort sars-cov-2 spike protein in intestinal cells of a patient with coronavirus disease 2019 multisystem inflammatory syndrome
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8626144/
https://www.ncbi.nlm.nih.gov/pubmed/34843710
http://dx.doi.org/10.1016/j.jpeds.2021.11.058
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