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The Potential of Mesenchymal Stem Cells for the Treatment of Cytokine Storm due to COVID-19

The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has seriously affected public health and social stability. The main route of the transmission is droplet transmission, where the oral cavity is the most important entry point to...

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Detalles Bibliográficos
Autores principales: Li, Xun, Yan, Mengchao, Chen, Jun, Luo, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8626179/
https://www.ncbi.nlm.nih.gov/pubmed/34840969
http://dx.doi.org/10.1155/2021/3178796
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author Li, Xun
Yan, Mengchao
Chen, Jun
Luo, Yang
author_facet Li, Xun
Yan, Mengchao
Chen, Jun
Luo, Yang
author_sort Li, Xun
collection PubMed
description The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has seriously affected public health and social stability. The main route of the transmission is droplet transmission, where the oral cavity is the most important entry point to the body. Due to both the direct harmful effects of SARS-CoV-2 and disordered immune responses, some COVID-19 patients may progress to acute respiratory distress syndrome or even multiple organ failure. Genetic variants of SARS-CoV-2 have been emerging and circulating around the world. Currently, there is no internationally approved precise treatment for COVID-19. Mesenchymal stem cells (MSCs) can traffic and migrate towards the affected tissue, regulate both the innate and acquired immune systems, and participate in the process of healing. Here, we will discuss and investigate the mechanisms of immune disorder in COVID-19 and the therapeutic activity of MSCs, in particular human gingiva mesenchymal stem cells.
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spelling pubmed-86261792021-11-27 The Potential of Mesenchymal Stem Cells for the Treatment of Cytokine Storm due to COVID-19 Li, Xun Yan, Mengchao Chen, Jun Luo, Yang Biomed Res Int Review Article The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has seriously affected public health and social stability. The main route of the transmission is droplet transmission, where the oral cavity is the most important entry point to the body. Due to both the direct harmful effects of SARS-CoV-2 and disordered immune responses, some COVID-19 patients may progress to acute respiratory distress syndrome or even multiple organ failure. Genetic variants of SARS-CoV-2 have been emerging and circulating around the world. Currently, there is no internationally approved precise treatment for COVID-19. Mesenchymal stem cells (MSCs) can traffic and migrate towards the affected tissue, regulate both the innate and acquired immune systems, and participate in the process of healing. Here, we will discuss and investigate the mechanisms of immune disorder in COVID-19 and the therapeutic activity of MSCs, in particular human gingiva mesenchymal stem cells. Hindawi 2021-11-26 /pmc/articles/PMC8626179/ /pubmed/34840969 http://dx.doi.org/10.1155/2021/3178796 Text en Copyright © 2021 Xun Li et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Li, Xun
Yan, Mengchao
Chen, Jun
Luo, Yang
The Potential of Mesenchymal Stem Cells for the Treatment of Cytokine Storm due to COVID-19
title The Potential of Mesenchymal Stem Cells for the Treatment of Cytokine Storm due to COVID-19
title_full The Potential of Mesenchymal Stem Cells for the Treatment of Cytokine Storm due to COVID-19
title_fullStr The Potential of Mesenchymal Stem Cells for the Treatment of Cytokine Storm due to COVID-19
title_full_unstemmed The Potential of Mesenchymal Stem Cells for the Treatment of Cytokine Storm due to COVID-19
title_short The Potential of Mesenchymal Stem Cells for the Treatment of Cytokine Storm due to COVID-19
title_sort potential of mesenchymal stem cells for the treatment of cytokine storm due to covid-19
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8626179/
https://www.ncbi.nlm.nih.gov/pubmed/34840969
http://dx.doi.org/10.1155/2021/3178796
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