SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis

COVID-19-induced “acute respiratory distress syndrome” (ARDS) is associated with prolonged respiratory failure and high mortality, but the mechanistic basis of lung injury remains incompletely understood. Here, we analyze pulmonary immune responses and lung pathology in two cohorts of patients with...

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Autores principales: Wendisch, Daniel, Dietrich, Oliver, Mari, Tommaso, von Stillfried, Saskia, Ibarra, Ignacio L., Mittermaier, Mirja, Mache, Christin, Chua, Robert Lorenz, Knoll, Rainer, Timm, Sara, Brumhard, Sophia, Krammer, Tobias, Zauber, Henrik, Hiller, Anna Luisa, Pascual-Reguant, Anna, Mothes, Ronja, Bülow, Roman David, Schulze, Jessica, Leipold, Alexander M., Djudjaj, Sonja, Erhard, Florian, Geffers, Robert, Pott, Fabian, Kazmierski, Julia, Radke, Josefine, Pergantis, Panagiotis, Baßler, Kevin, Conrad, Claudia, Aschenbrenner, Anna C., Sawitzki, Birgit, Landthaler, Markus, Wyler, Emanuel, Horst, David, Hippenstiel, Stefan, Hocke, Andreas, Heppner, Frank L., Uhrig, Alexander, Garcia, Carmen, Machleidt, Felix, Herold, Susanne, Elezkurtaj, Sefer, Thibeault, Charlotte, Witzenrath, Martin, Cochain, Clément, Suttorp, Norbert, Drosten, Christian, Goffinet, Christine, Kurth, Florian, Schultze, Joachim L., Radbruch, Helena, Ochs, Matthias, Eils, Roland, Müller-Redetzky, Holger, Hauser, Anja E., Luecken, Malte D., Theis, Fabian J., Conrad, Christian, Wolff, Thorsten, Boor, Peter, Selbach, Matthias, Saliba, Antoine-Emmanuel, Sander, Leif Erik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Inc. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8626230/
https://www.ncbi.nlm.nih.gov/pubmed/34914922
http://dx.doi.org/10.1016/j.cell.2021.11.033

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