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Anti-aging and antioxidant of four traditional malaysian plants using simplex centroid mixture design approach

Aging is a naturally biological process with adverse effects. The continuous accumulation of reactive oxygen species (ROS) trigger cellular and tissue damage by activating several aging enzymes. The antioxidant properties of traditional medicinal plants used by Jakun aborigine’s community are a prom...

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Autores principales: Ranneh, Yazan, Abu Bakar, Mohd Fadzelly, Ismail, Nur Amalina, Kormin, Faridah, Mohamed, Maryati, Md Akim, Abdah, Isha, Azizul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8626306/
https://www.ncbi.nlm.nih.gov/pubmed/34866970
http://dx.doi.org/10.1016/j.sjbs.2021.07.048
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author Ranneh, Yazan
Abu Bakar, Mohd Fadzelly
Ismail, Nur Amalina
Kormin, Faridah
Mohamed, Maryati
Md Akim, Abdah
Isha, Azizul
author_facet Ranneh, Yazan
Abu Bakar, Mohd Fadzelly
Ismail, Nur Amalina
Kormin, Faridah
Mohamed, Maryati
Md Akim, Abdah
Isha, Azizul
author_sort Ranneh, Yazan
collection PubMed
description Aging is a naturally biological process with adverse effects. The continuous accumulation of reactive oxygen species (ROS) trigger cellular and tissue damage by activating several aging enzymes. The antioxidant properties of traditional medicinal plants used by Jakun aborigine’s community are a promising approach to alleviate aging process and prevent Alzheimer. The aim of the current investigation was to optimize a novel anti-aging formulation from traditional plants (Cnestis palala stem, Urceola micrantha stem, Marantodes pumilum stem and Microporus xanthopus fruiting bodies) using simplex centroid mixture design (SCMD). After selecting the optimal formulations based on desirability function of antioxidant activity (DPPḢ, ABTS(˙)(+) and FRAP), they were further examined against the activity of aging-related-enzymes (collagenase, tyrosinase, acetyl- and butyrylcholinesterase). The single extracts of C. palala, U. micrantha and the binary mixture of C. palala and U. micrantha were the optimal formulations with high antioxidant activities. Single extract of U. micrantha showed the highest inhibition towards matrix metalloproteinase-1 (49.44 ± 4.11 %), while C. palala water extract showed highest inhibitions towards tyrosinase (14.06 ± 0.31%), acetylcholinesterase (32.92 ± 2.13%) and butyrylcholinesterase (34.89 ± 2.84%) enzymes. The single extracts of C. palala and U. micrantha displayed better activity as compared to the binary mixture formulation. In conclusion, these findings could be a baseline for further exploration of novel anti-aging agents from natural resources.
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spelling pubmed-86263062021-12-02 Anti-aging and antioxidant of four traditional malaysian plants using simplex centroid mixture design approach Ranneh, Yazan Abu Bakar, Mohd Fadzelly Ismail, Nur Amalina Kormin, Faridah Mohamed, Maryati Md Akim, Abdah Isha, Azizul Saudi J Biol Sci Original Article Aging is a naturally biological process with adverse effects. The continuous accumulation of reactive oxygen species (ROS) trigger cellular and tissue damage by activating several aging enzymes. The antioxidant properties of traditional medicinal plants used by Jakun aborigine’s community are a promising approach to alleviate aging process and prevent Alzheimer. The aim of the current investigation was to optimize a novel anti-aging formulation from traditional plants (Cnestis palala stem, Urceola micrantha stem, Marantodes pumilum stem and Microporus xanthopus fruiting bodies) using simplex centroid mixture design (SCMD). After selecting the optimal formulations based on desirability function of antioxidant activity (DPPḢ, ABTS(˙)(+) and FRAP), they were further examined against the activity of aging-related-enzymes (collagenase, tyrosinase, acetyl- and butyrylcholinesterase). The single extracts of C. palala, U. micrantha and the binary mixture of C. palala and U. micrantha were the optimal formulations with high antioxidant activities. Single extract of U. micrantha showed the highest inhibition towards matrix metalloproteinase-1 (49.44 ± 4.11 %), while C. palala water extract showed highest inhibitions towards tyrosinase (14.06 ± 0.31%), acetylcholinesterase (32.92 ± 2.13%) and butyrylcholinesterase (34.89 ± 2.84%) enzymes. The single extracts of C. palala and U. micrantha displayed better activity as compared to the binary mixture formulation. In conclusion, these findings could be a baseline for further exploration of novel anti-aging agents from natural resources. Elsevier 2021-12 2021-07-22 /pmc/articles/PMC8626306/ /pubmed/34866970 http://dx.doi.org/10.1016/j.sjbs.2021.07.048 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Ranneh, Yazan
Abu Bakar, Mohd Fadzelly
Ismail, Nur Amalina
Kormin, Faridah
Mohamed, Maryati
Md Akim, Abdah
Isha, Azizul
Anti-aging and antioxidant of four traditional malaysian plants using simplex centroid mixture design approach
title Anti-aging and antioxidant of four traditional malaysian plants using simplex centroid mixture design approach
title_full Anti-aging and antioxidant of four traditional malaysian plants using simplex centroid mixture design approach
title_fullStr Anti-aging and antioxidant of four traditional malaysian plants using simplex centroid mixture design approach
title_full_unstemmed Anti-aging and antioxidant of four traditional malaysian plants using simplex centroid mixture design approach
title_short Anti-aging and antioxidant of four traditional malaysian plants using simplex centroid mixture design approach
title_sort anti-aging and antioxidant of four traditional malaysian plants using simplex centroid mixture design approach
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8626306/
https://www.ncbi.nlm.nih.gov/pubmed/34866970
http://dx.doi.org/10.1016/j.sjbs.2021.07.048
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